INT85971

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Context Info
Confidence 0.66
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 7.61
Pain Relevance 3.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cd40lg) extracellular space (Cd40lg) extracellular region (Cd40lg)
plasma membrane (Cd40lg)
Anatomy Link Frequency
T cells 8
astrocytes 4
platelet 4
B cells 2
Cd40lg (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 35 99.56 Very High Very High Very High
Arthritis 66 98.52 Very High Very High Very High
Angina 21 97.88 Very High Very High Very High
Inflammatory response 2 97.84 Very High Very High Very High
rheumatoid arthritis 29 97.20 Very High Very High Very High
Inflammatory marker 35 94.24 High High
Inflammation 134 93.60 High High
Multiple sclerosis 14 93.40 High High
Central nervous system 12 91.16 High High
chemokine 4 83.84 Quite High
Disease Link Frequency Relevance Heat
Thrombosis 27 99.66 Very High Very High Very High
Disease 95 99.28 Very High Very High Very High
Amyloid Plaque 2 99.04 Very High Very High Very High
Rupture 1 98.72 Very High Very High Very High
Experimental Arthritis 40 98.52 Very High Very High Very High
Cv General 3 Under Development 19 97.88 Very High Very High Very High
INFLAMMATION 171 97.44 Very High Very High Very High
Rheumatoid Arthritis 30 97.20 Very High Very High Very High
Myocardial Infarction 13 97.08 Very High Very High Very High
Diabetes Mellitus 46 96.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that the rupture of plaque and subsequent formation of thrombus may lead to the activation of CD40L expression in circulating platelets of ACS patients.
Positive_regulation (activation) of Gene_expression (expression) of CD40L in platelets associated with rupture and thrombosis
1) Confidence 0.66 Published 1999 Journal Cardiology Section Abstract Doc Link 10640791 Disease Relevance 0.90 Pain Relevance 0.23
It has been demonstrated that overexpression of CD154 (CD40L) on T cells correlates with higher disease activity [5], which is confirmed by studies showing treatment of mice with agonistic anti-CD40 Abs at the time of CIA induction exacerbates disease [6].
Positive_regulation (overexpression) of Gene_expression (overexpression) of CD40L in T cells associated with disease and arthritis
2) Confidence 0.53 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 1.20 Pain Relevance 0.52
A median increase in sCD40L expression from 224 to 324.5 pg/ml was observed between baseline and 4 weeks after clopidogrel cessation, which corresponded to a 39% mean percent change based on an ANCOVA model (P < 0.001).
Positive_regulation (increase) of Gene_expression (expression) of sCD40L
3) Confidence 0.39 Published 2009 Journal J Thromb Thrombolysis Section Abstract Doc Link PMC2766044 Disease Relevance 0.38 Pain Relevance 0.12
It has been demonstrated that overexpression of CD154 (CD40L) on T cells correlates with higher disease activity [5], which is confirmed by studies showing treatment of mice with agonistic anti-CD40 Abs at the time of CIA induction exacerbates disease [6].
Positive_regulation (overexpression) of Gene_expression (overexpression) of CD154 in T cells associated with disease and arthritis
4) Confidence 0.39 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 1.15 Pain Relevance 0.49
Interestingly, we could not document any increase in CD154 (the CD40 ligand) on T cells, and therefore decided not to include CD154 in our standard panel.
Positive_regulation (increase) of Gene_expression (ligand) of CD154 in T cells
5) Confidence 0.38 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.27 Pain Relevance 0.03
Furthermore, the CD40-CD40L dyad is potentiated, as can be seen from the increased numbers of CD40-positive microglial cells as well as increased CD40L expression on astrocytes in AD [53,54].
Positive_regulation (increased) of Gene_expression (expression) of CD40L in astrocytes associated with disease
6) Confidence 0.36 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.80 Pain Relevance 0.31
Furthermore, the CD40-CD40L dyad is potentiated, as can be seen from the increased numbers of CD40-positive microglial cells as well as increased CD40L expression on astrocytes in AD [53,54].
Positive_regulation (increased) of Gene_expression (expression) of CD40L in astrocytes associated with disease
7) Confidence 0.36 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1352348 Disease Relevance 0.82 Pain Relevance 0.33
This study was exploratory in nature, but nevertheless demonstrated a significant increase in CD40L expression after clopidogrel cessation indicative of possible enhanced platelet activation.
Positive_regulation (increase) of Gene_expression (expression) of CD40L in platelet
8) Confidence 0.30 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.24 Pain Relevance 0.10
Increased expression of T cell activation markers (CD25, CD26, CD40L and CD69) in atherectomy specimens of patients with unstable angina and acute myocardial infarction.
Positive_regulation (Increased) of Gene_expression (expression) of CD40L in T cell associated with angina and myocardial infarction
9) Confidence 0.28 Published 2003 Journal Atherosclerosis Section Title Doc Link 12732389 Disease Relevance 0.77 Pain Relevance 0.34
Changes in soluble P-selectin levels correlated only weakly with changes in sCD40L levels (correlation coefficient reached 0.32 at 4 weeks with P = 0.024; Fig. 2).Fig. 2Correlation between sCD40L and P-selectin levels
Positive_regulation (between) of Gene_expression (levels) of sCD40L
10) Confidence 0.28 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.31 Pain Relevance 0.22
Changes in soluble P-selectin levels correlated only weakly with changes in sCD40L levels (correlation coefficient reached 0.32 at 4 weeks with P = 0.024; Fig. 2).Fig. 2Correlation between sCD40L and P-selectin levels
Positive_regulation (between) of Gene_expression (levels) of sCD40L
11) Confidence 0.28 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.39 Pain Relevance 0.24
Changes in soluble P-selectin levels correlated only weakly with changes in sCD40L levels (correlation coefficient reached 0.32 at 4 weeks with P = 0.024; Fig. 2).Fig. 2Correlation between sCD40L and P-selectin levels
Positive_regulation (.Fig.) of Gene_expression (levels) of sCD40L
12) Confidence 0.28 Published 2009 Journal J Thromb Thrombolysis Section Body Doc Link PMC2766044 Disease Relevance 0.32 Pain Relevance 0.23
This leads to the expression of CD154 (or CD40 ligand) on the T cell, which engages the counter-receptor, CD40, to be expressed on B cells.
Positive_regulation (leads) of Gene_expression (expression) of CD154 in B cells
13) Confidence 0.05 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 0 Pain Relevance 0.15
In a multivariable model, elevated levels of TnT (HR, 1.83; 95% CI, 1.05-3.86; P =.03), sCD40L (HR, 2.65; 95% CI, 1.41-4.99; P =.002), and PlGF (HR, 3.03; 95% CI, 1.54-5.95; P<.001) were independent predictors, while elevated hsCRP level was not (HR, 0.98; 95% CI, 0.53-1.98; P =.94).
Positive_regulation (elevated) of Gene_expression (levels) of sCD40L
14) Confidence 0.00 Published 2004 Journal JAMA Section Body Doc Link 14747500 Disease Relevance 0.06 Pain Relevance 0

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