INT85995

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Context Info
Confidence 0.45
First Reported 2000
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 13
Disease Relevance 3.39
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (NCR1) plasma membrane (NCR1)
Anatomy Link Frequency
NK cell 2
stroma 1
decidua 1
ovary 1
NCR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 190 100.00 Very High Very High Very High
orphanin 7 98.82 Very High Very High Very High
Sicca syndrome 2 94.92 High High
Buprenorphine 1 86.80 High High
Inflammation 76 81.52 Quite High
agonist 1 64.80 Quite High
imagery 26 5.00 Very Low Very Low Very Low
alcohol 16 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 254 98.94 Very High Very High Very High
Autoimmune Disease 2 98.36 Very High Very High Very High
Death 40 96.40 Very High Very High Very High
Syndrome 6 94.92 High High
Systemic Lupus Erythematosus 68 88.96 High High
INFLAMMATION 74 81.52 Quite High
Pancreatic Cancer 2 79.92 Quite High
Metastasis 16 77.52 Quite High
Disease 32 74.92 Quite High
Apoptosis 44 70.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Wilcoxon test was used to compare production of cytokines and growth factors (in different conditions of hormones concentration) and TWEAK, IL-18, NKp46 and TGF-?
Gene_expression (production) of NKp46 associated with cytokine
1) Confidence 0.45 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.05
Manaster et al, reported that both proliferative and secretory phase uNK cells express NKp46 and NKG2D, but do not express NKp44 and NKp30, at the opposite of NK cells from decidua which express high levels of NKp30, NKp44 and NKG2D [26].
Gene_expression (express) of NKp46 in decidua
2) Confidence 0.45 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.12
NKp46 protein expression was also detailed by immunohistochemistry in selected patients with high basic mRNA level of IL-18 and either low or high mRNA level of TWEAK.
Gene_expression (expression) of NKp46
3) Confidence 0.45 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017546 Disease Relevance 0.32 Pain Relevance 0.08
The NKp46 protein was mainly detectable in the luminal and glandular epithelium and within the stroma around the spiral arteries.
Gene_expression (detectable) of NKp46 in stroma
4) Confidence 0.45 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.19
Wilcoxon test was used to compare production of cytokines and growth factors (in different conditions of hormones concentration) and TWEAK, IL-18, NKp46 and TGF-?
Gene_expression (production) of NKp46 associated with cytokine
5) Confidence 0.39 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.05
In order to verify whether TWEAK could counterbalance IL-18 cytotoxic effect on uNK cells, we quantified, in different culture conditions, the expression of two proteins: NKp46, which mediates uNK cells cytotoxic effects and TGF-?
Gene_expression (expression) of NKp46
6) Confidence 0.39 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.08 Pain Relevance 0.07
However, as previously suggested, we confirmed that TWEAK acts on the uNK cells cytotoxicity, induced by IL-18 over-expression, by modifying one of the uNK cells cytotoxic receptor expression, NKp46.
Gene_expression (expression) of NKp46
7) Confidence 0.35 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.04
We used this ex vivo model to study mRNA expressions of NKp46 (a uNK cytotoxic receptor) and TGF-beta1 (protein which regulates uNK cytokine production) after adjunction of excess of recombinant IL-18 and either recombinant TWEAK or its antibody.
Gene_expression (expressions) of NKp46 associated with cytokine
8) Confidence 0.35 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017546 Disease Relevance 0.30 Pain Relevance 0.05
For blocking of the cytolytic activity the NK specific antibodies directed against NKp30, NKp44, NKp46 (Immunotech, Marseille, France) and the antibodies directed against Hsp70 (cmHsp70.2, multimmune GmbH) and MICA/B (BAMO1, IgG1; BAMO2, IgG2a, Bamomab, Munich, Germany) on tumor cells were used.
Gene_expression (directed) of NKp46 associated with cancer
9) Confidence 0.29 Published 2009 Journal J Transl Med Section Body Doc Link PMC2714296 Disease Relevance 0.42 Pain Relevance 0
By contrast to these results, the expression of NKp44 (data not shown), NKp46 and NKp30 were not significantly different from controls.
Gene_expression (expression) of NKp46
10) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.75 Pain Relevance 0.08
Phenotypical characterization of NK cells was performed by analyzing the expression of many receptors such as NKp46, NKp30, NKp44, NKG2D, CD244, CD2, CD16, CD69, CD159a, CD158a/h, CD158b1/b2/j, CD158e1/e2, CD158i and NKG2A.
Spec (analyzing) Gene_expression (expression) of NKp46 in NK cells
11) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707004 Disease Relevance 0.62 Pain Relevance 0
The enhanced cytolytic activity against Hsp70 surface-positive tumors is accompanied by, and correlates with an increased expression density of NK cell receptors including CD94/NKG2A/C, NKG2D and NCRs such as NKp30, NKp44, NKp46 [2,3,12].
Gene_expression (expression) of NKp46 in NK cell associated with cancer
12) Confidence 0.11 Published 2009 Journal J Transl Med Section Body Doc Link PMC2714296 Disease Relevance 0.91 Pain Relevance 0
In this study we describe the inhibitory action of the novel NC analogue, [Nphe1]nociceptin(1-13)NH2 on cAMP formation in Chinese hamster ovary cells expressing the human NCR.
Gene_expression (expressing) of NCR in ovary associated with orphanin
13) Confidence 0.08 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10643813 Disease Relevance 0 Pain Relevance 0.41

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