INT85999

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Context Info
Confidence 0.27
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.84
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd5) signal transducer activity (Drd5)
Drd5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 4 98.52 Very High Very High Very High
Hyperalgesia 2 98.32 Very High Very High Very High
Neuropathic pain 2 96.84 Very High Very High Very High
conotoxin 1 87.84 High High
Neuropeptide 3 79.52 Quite High
withdrawal 3 79.44 Quite High
Thermal hyperalgesia 1 76.60 Quite High
Nicotine 1 73.56 Quite High
alcohol 1 73.00 Quite High
Morphine 2 72.64 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 3 99.10 Very High Very High Very High
Hyperalgesia 3 98.32 Very High Very High Very High
Neuropathic Pain 2 96.84 Very High Very High Very High
Aids-related Complex 11 77.88 Quite High
Neuroblastoma 1 69.04 Quite High
Drug Dependence 2 38.96 Quite Low
Cocaine Dependence 10 5.00 Very Low Very Low Very Low
Recurrence 8 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Osteogenic Sarcomas 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Network analysis was conducted using the set of confirmed mPFC gene expression changes, and revealed that Cart, NPY, Nr4a1, Fos, Egr1, Adora2b and Drd5 all interact (directly or indirectly) with the MAPK/ERK pathway.
Drd5 Binding (interact) of
1) Confidence 0.27 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.08 Pain Relevance 0.25
The results suggest a mechanism whereby VDCC are modulated by a pertussis toxin-sensitive G-protein coupled receptor; D5 binds to this receptor and thereby ameliorates hyperalgesia in the Seltzer model of neuropathic pain.
D5 Binding (binds) of associated with hyperalgesia, bordatella infection, calcium channel and neuropathic pain
2) Confidence 0.15 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10643816 Disease Relevance 0.76 Pain Relevance 0.69

General Comments

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