INT860

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Context Info
Confidence 0.60
First Reported 1976
Last Reported 2010
Negated 11
Speculated 6
Reported most in Abstract
Documents 48
Total Number 55
Disease Relevance 25.11
Pain Relevance 8.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ALB) small molecule metabolic process (ALB) enzyme binding (ALB)
DNA binding (ALB) protein complex (ALB) transmembrane transport (ALB)
Anatomy Link Frequency
plasma 8
blood 2
liver 2
Muscle 2
nasal 1
ALB (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 95 100.00 Very High Very High Very High
ischemia 35 100.00 Very High Very High Very High
palliative 12 100.00 Very High Very High Very High
Clonidine 6 100.00 Very High Very High Very High
Opioid 4 99.76 Very High Very High Very High
Morphine 23 99.50 Very High Very High Very High
Thoracotomy 10 99.32 Very High Very High Very High
Inflammatory response 15 99.04 Very High Very High Very High
lidocaine 19 99.00 Very High Very High Very High
Analgesic 5 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 619 100.00 Very High Very High Very High
INFLAMMATION 200 100.00 Very High Very High Very High
Colon Cancer 62 100.00 Very High Very High Very High
Cv Unclassified Under Development 28 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 25 100.00 Very High Very High Very High
Anastomotic Leak 4 100.00 Very High Very High Very High
Coronary Artery Disease 14 99.66 Very High Very High Very High
Breast Cancer 44 99.40 Very High Very High Very High
Infection 166 99.36 Very High Very High Very High
Pressure And Volume Under Development 42 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The range of normal values set by the hospital's clinical laboratory was used to define the threshold values for low serum albumin and protein levels.


Regulation (values) of serum albumin
1) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965679 Disease Relevance 0.75 Pain Relevance 0.04
The drugs, which had some effect on cholesterol crystallization, affected somehow the artificial lipid-albumin complex by displacing its components.
Regulation (affected) of lipid-albumin
2) Confidence 0.54 Published 2003 Journal Fundam Clin Pharmacol Section Abstract Doc Link 12803572 Disease Relevance 0 Pain Relevance 0.39
[The effects of various drugs on the binding site of bilirubin in serum albumin].
Regulation (effects) of serum albumin
3) Confidence 0.45 Published 1984 Journal Nippon Yakurigaku Zasshi Section Title Doc Link 6714852 Disease Relevance 0.09 Pain Relevance 0.09
Studies should also prospectively evaluate whether nutritional intervention could have a positive impact on serum albumin levels with a subsequent improvement in patient survival.
Regulation (impact) of serum albumin
4) Confidence 0.45 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 0.38 Pain Relevance 0
A study investigated the effect of baseline serum albumin levels on 180 breast cancer patients.
Spec (investigated) Regulation (effect) of serum albumin associated with breast cancer
5) Confidence 0.45 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 0.90 Pain Relevance 0.03
Univariate statistical analysis found that low levels of serum albumin adversely affected survival by a statistically significant level for all stages of breast cancer while Cox regression analysis found that normal levels of albumin (>3.5 g/dL) reduced the risk of death by 72% (p = .0033) [46].
Regulation (affected) of serum albumin associated with breast cancer and death
6) Confidence 0.45 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 0.99 Pain Relevance 0.03
Since we speculated that these drugs could also act by protecting endogenous proteins against denaturation, we evaluated their effect on heat-induced denaturation human serum albumin (HSA) in comparison with several fatty acids which are known to be potent stabilizers of this protein.
Regulation (effect) of serum albumin
7) Confidence 0.45 Published 2001 Journal Arch. Pharm. Res. Section Abstract Doc Link 11339635 Disease Relevance 0.34 Pain Relevance 0.40
Both bivariate and multivariate statistical analysis with logistic regression showed that the following clinical and biologic factors do not influence anastomotic leakage: tumor stage, the curative or palliative purpose of resection, neoplastic permeation of anastomotic margins, total protein concentration below 5 gm/dl, albumin concentration below 3 gm/dl, patient's age, diabetes, high blood pressure, cirrhosis of the liver, and cardiac, respiratory, or renal diseases.
Regulation (influence) of albumin in liver associated with cirrhosis, anastomotic leak, diabetes mellitus, cancer, renal disease, hypertension and palliative
8) Confidence 0.44 Published 1988 Journal J. Thorac. Cardiovasc. Surg. Section Abstract Doc Link 3280882 Disease Relevance 1.06 Pain Relevance 0.10
The report describes the results of a study the effect of pH and binding of six physiologically active compounds (isoproterenol, yohimbine, theophylline, propranolol, clonidine and carbachol) on the molecular structure of human serum albumin (HSA) using dynamic light scattering.
Regulation (effect) of albumin associated with clonidine
9) Confidence 0.43 Published 1998 Journal J. Biomol. Struct. Dyn. Section Abstract Doc Link 9745899 Disease Relevance 0 Pain Relevance 0.15
The influence of pH alteration and pharmacological modulators of adenylate cyclase system on human serum albumin conformation.
Regulation (influence) of albumin
10) Confidence 0.43 Published 1998 Journal J. Biomol. Struct. Dyn. Section Title Doc Link 9745899 Disease Relevance 0 Pain Relevance 0.16
The effect of pH and binding of ten physiologically active compounds (isoproterenol, yohimbine, propranolol, clonidine, phenylephrine, carbachol, tripeptide fMLP, diphenhydramine, chlorpromazine and atropine) on the molecular structure of human serum albumin (HSA) has been studied using the dynamic light scattering.
Regulation (effect) of albumin associated with clonidine
11) Confidence 0.41 Published 1998 Journal Spectrochim Acta A Mol Biomol Spectrosc Section Abstract Doc Link 9807240 Disease Relevance 0 Pain Relevance 0.15
Plasma levels of Na+, K+, urea, and albumin remained unchanged from 0 to 60 days after amalgam.
Neg (unchanged) Regulation (unchanged) of albumin in Plasma
12) Confidence 0.41 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1928419 Disease Relevance 0 Pain Relevance 0.06
The influence of the protein (albumin) binding on the pharmacokinetics of these solutes is characterized by the default PKQuest values for KAi in the different organs (Table 6, see Appendix, II and III) and the experimental values for the fraction bound in plasma (fp, Table 1).
Regulation (influence) of albumin in plasma
13) Confidence 0.41 Published 2003 Journal BMC Clin Pharmacol Section Body Doc Link PMC194216 Disease Relevance 0 Pain Relevance 0
This group had lower concentrations of both albumin and alpha 1-acid glycoprotein (AAG), achieving statistical significance vs control for albumin only.
Regulation (control) of albumin
14) Confidence 0.38 Published 1993 Journal Clin Pharmacokinet Section Abstract Doc Link 8453825 Disease Relevance 0.60 Pain Relevance 0.42
The effect of a series of non-steroidal anti-inflammatory drugs (NSAIDs) on the binding kinetics of dansylsarcosine (CAS 72517-44-3, DS), a marker ligand for the benzodiazepine binding site, and human serum albumin (HSA) was studied using the stopped-flow method.
Regulation (effect) of albumin associated with inflammation and cinod
15) Confidence 0.37 Published 1996 Journal Arzneimittelforschung Section Abstract Doc Link 8720306 Disease Relevance 0.17 Pain Relevance 0.56
This study examined the effect of changes in plasma concentrations of total protein, albumin, alpha 1-acid glycoprotein, and free fatty acids occurring after heart operations on the protein binding of chemically basic drugs.
Spec (examined) Regulation (changes) of albumin in plasma
16) Confidence 0.34 Published 1988 Journal J. Thorac. Cardiovasc. Surg. Section Abstract Doc Link 3172810 Disease Relevance 0 Pain Relevance 0.15
Based on these results we studied a possible change in the concentration of cystatin S, cystatin C, albumin, IgA, amylase activity, and cystatin activity in a whole and parotid saliva of 20 periodontitis patients as a consequence of periodontal treatment.
Spec (possible) Regulation (change) of albumin in saliva associated with periodontitis
17) Confidence 0.30 Published 1996 Journal J. Periodontol. Section Abstract Doc Link 8708950 Disease Relevance 0.45 Pain Relevance 0.12
In young healthy adults these sex-related differences in drug disposition were related to the phase of the menstrual cycle, oral contraceptive steroid administration, and variations in plasma concentrations of albumin, alpha 1-acid glycoprotein, free fatty acids and sex hormones.
Regulation (concentrations) of albumin in plasma
18) Confidence 0.27 Published 1984 Journal Clin Pharmacokinet Section Abstract Doc Link 6375930 Disease Relevance 0.08 Pain Relevance 0.08
Ischemia-modified albumin
Regulation (modified) of albumin associated with ischemia
19) Confidence 0.27 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 1.59 Pain Relevance 0.51
Muscle ischemia, low albumin levels and physical exercise have all been shown to affect ischemia-modified albumin levels [88-90].


Regulation (affect) of albumin in Muscle associated with ischemia
20) Confidence 0.27 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 1.45 Pain Relevance 0.47

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