INT86006

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Context Info
Confidence 0.53
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.22
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Aldh1a1) cytoplasm (Aldh1a1)
Anatomy Link Frequency
arm 1
gland 1
Aldh1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 2 99.08 Very High Very High Very High
Spinal cord 6 74.28 Quite High
Cancer pain 41 71.64 Quite High
Pain 54 50.08 Quite High
allodynia 5 45.92 Quite Low
Thermal hyperalgesia 3 44.92 Quite Low
antagonist 58 40.12 Quite Low
Dopamine 15 25.00 Low Low
opiate 2 25.00 Low Low
Neurotransmitter 8 20.64 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 26 100.00 Very High Very High Very High
Chronic Lymphoid Leukemia 1 99.60 Very High Very High Very High
Hyperopia 2 97.76 Very High Very High Very High
Myopia 6 97.24 Very High Very High Very High
Cancer 102 96.24 Very High Very High Very High
Breast Cancer 18 95.00 High High
Prostate Cancer 3 90.00 High High
Bladder Cancer 5 89.20 High High
Bone Cancer 28 71.44 Quite High
Cancer Pain 12 64.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have studied in which fundal tissues aldehyde dehydrogenase-2 (AHD2) and retinaldehyde dehydrogenase-2 (RALDH2), enzymes involved in RA synthesis, are expressed and at which levels the effects of vision on RA levels may be controlled.
Gene_expression (expressed) of AHD2 associated with rheumatoid arthritis
1) Confidence 0.53 Published 2000 Journal Exp. Eye Res. Section Abstract Doc Link 10644425 Disease Relevance 0.70 Pain Relevance 0
We have studied in which fundal tissues aldehyde dehydrogenase-2 (AHD2) and retinaldehyde dehydrogenase-2 (RALDH2), enzymes involved in RA synthesis, are expressed and at which levels the effects of vision on RA levels may be controlled.
Gene_expression (expressed) of aldehyde dehydrogenase-2 associated with rheumatoid arthritis
2) Confidence 0.53 Published 2000 Journal Exp. Eye Res. Section Abstract Doc Link 10644425 Disease Relevance 0.71 Pain Relevance 0
In the adult gland, RALDH1 is the expressed isoform (786).
Gene_expression (expressed) of RALDH1 in gland
3) Confidence 0.24 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.57 Pain Relevance 0
The expression and activity of formaldehyde generating enzymes, such as lysine-specific demethylase 1 (LSD1) [25], [26], semicarbazide-sensitive amine oxidase (SSAO) [27], [28] and cytochrome P-450 [29], [30], formaldehyde degrading enzymes, such as aldehyde dehydrogenase 2 (ALDH2) and class III alcohol dehydrogenase (ADH3) [31], [32], are considered to have critical roles in the pathogenesis of breast cancer.
Gene_expression (expression) of aldehyde dehydrogenase 2 associated with breast cancer and alcohol
4) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2858155 Disease Relevance 1.25 Pain Relevance 0.43
Increased glycolytic enzymes were coupled to a 50% higher expression of the cytosolic arm of the malate/aspartate NADH shuttle: aspartate aminotransferase 1 (Got1, 44% up) and malate dehydrogenase 1 (Mdh1, 77% up) (Fig. 5a).
Gene_expression (expression) of dehydrogenase 1 in arm
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997773 Disease Relevance 0 Pain Relevance 0

General Comments

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