INT86023

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Context Info
Confidence 0.66
First Reported 2000
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 60
Total Number 60
Disease Relevance 25.80
Pain Relevance 5.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
liver 2
plasma 1
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 602 99.96 Very High Very High Very High
adenocard 3 97.44 Very High Very High Very High
Inflammation 548 97.36 Very High Very High Very High
ischemia 30 97.24 Very High Very High Very High
Bile 57 96.64 Very High Very High Very High
Osteoarthritis 65 96.24 Very High Very High Very High
cytokine 157 95.60 Very High Very High Very High
dexamethasone 31 93.36 High High
cINOD 108 92.00 High High
Inflammatory response 48 89.68 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 62 100.00 Very High Very High Very High
Hypoxia 86 99.92 Very High Very High Very High
Lung Cancer 69 99.48 Very High Very High Very High
Diabetes Mellitus 434 99.40 Very High Very High Very High
Prostate Cancer 66 98.40 Very High Very High Very High
Colorectal Cancer 50 98.04 Very High Very High Very High
INFLAMMATION 639 97.36 Very High Very High Very High
Apoptosis 571 97.28 Very High Very High Very High
Cv Unclassified Under Development 18 97.24 Very High Very High Very High
Nasal Polyps 41 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The adult PPAR expression patterns have been extensively established at the mRNA
Transcription (established) of PPAR
1) Confidence 0.66 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0 Pain Relevance 0
functions described for PPAR?
Transcription (described) of PPAR
2) Confidence 0.66 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0 Pain Relevance 0.03
This results in transcription of PPAR?
Transcription (transcription) of PPAR
3) Confidence 0.64 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686257 Disease Relevance 0.71 Pain Relevance 0.07
At the transcriptional level, PPAR agonists have been shown to
Transcription (transcriptional) of PPAR associated with agonist
4) Confidence 0.59 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490577 Disease Relevance 0.84 Pain Relevance 0.19
pleiotropic functions ascribed to PPAR?
Transcription (ascribed) of PPAR
5) Confidence 0.59 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 0.09 Pain Relevance 0
54,642 G probe described above and a ‘variantÂ’ PPARA ?
Transcription (described) of PPARA
6) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
These data clearly demonstrate that PPAR?
Transcription (demonstrate) of PPAR
7) Confidence 0.58 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0.64 Pain Relevance 0
It has been shown that mice with a targeted disruption of the PPAR?
Transcription (disruption) of PPAR associated with targeted disruption
8) Confidence 0.57 Published 2009 Journal PPAR Research Section Body Doc Link PMC2770108 Disease Relevance 1.66 Pain Relevance 0.40
These studies demonstrate that PPAR?
Transcription (demonstrate) of PPAR
9) Confidence 0.56 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.17
11-week pioglitazone treatment, unlike the increases observed for the transcript levels of the established PPAR?
Transcription (levels) of PPAR
10) Confidence 0.55 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.47 Pain Relevance 0.04
We found that co-expression of PPAR delta, retinoid X receptor (RXR) alpha, and coactivators such as CBP and SRC-1 enhanced basal and agonist-dependent activation of PPAR responsive element (PPRE)-driven transcription by PPAR delta, rendering a PPRE-driven reporter assay reliable and sensitive.
Transcription (transcription) of PPAR associated with agonist
11) Confidence 0.53 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14646253 Disease Relevance 0.24 Pain Relevance 0.63
c-FLIP mRNA, thus demonstrating a mechanism by which PPAR?
Transcription (demonstrating) of PPAR
12) Confidence 0.52 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.70 Pain Relevance 0.26
have been described PPAR ?
Transcription (described) of PPAR
13) Confidence 0.52 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490577 Disease Relevance 0.39 Pain Relevance 0.07
activation impairs post-ischemic cardiac function in experimental models of DM, we tested whether decreased PPARA transcription in PPARA A carriers favorably impacted outcome after acute coronary ischemia in 705 patients hospitalized with acute coronary syndromes (ACS; 552 Caucasian, 106 African American).
Transcription (transcription) of PPARA associated with acute coronary syndrome, diabetes mellitus and ischemia
14) Confidence 0.52 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2933242 Disease Relevance 0.92 Pain Relevance 0.12
Likewise, transcript levels for PPAR?
Transcription (levels) of PPAR
15) Confidence 0.52 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2533346 Disease Relevance 0.94 Pain Relevance 0.03
demonstrated to reduce the mRNA levels of PPAR-?
Transcription (levels) of PPAR
16) Confidence 0.51 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 1.13 Pain Relevance 0
Although a direct control of PPAR transcription is limited
Transcription (transcription) of PPAR
17) Confidence 0.51 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.65 Pain Relevance 0.31
expression level of the PPAR-?
Transcription (level) of PPAR
18) Confidence 0.49 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.75 Pain Relevance 0.08
context, the concentration range of PPAR-?
Transcription (range) of PPAR
19) Confidence 0.49 Published 2008 Journal PPAR Research Section Body Doc Link PMC2366048 Disease Relevance 0.60 Pain Relevance 0
Stimulated mRNA expression of uncoupling protein 2 (Ucp2) by PPAR?
Transcription (expression) of PPAR
20) Confidence 0.49 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.96 Pain Relevance 0.10

General Comments

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