INT86024

Context Info Confidence 0.78 First Reported 2000 Last Reported 2011 Negated 16 Speculated 20 Reported most in Body Documents 736 Total Number 756 Disease Relevance 497.93 Pain Relevance 91.14

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA) nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)

Anatomy Link Frequency liver 14 adipocytes 11 macrophages 7 adipose tissue 6 colon 4 PPARA (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 11435 100.00 Osteoarthritis 2309 100.00 cINOD 1709 100.00 dexamethasone 311 100.00 Endocannabinoid 150 100.00 Inflammation 8630 99.98 COX2 266 99.98 antagonist 1592 99.84 ischemia 418 99.70 Adalimumab 365 99.44

Disease Link Frequency Relevance Heat Apoptosis 12983 100.00 Obesity 10140 100.00 Diabetes Mellitus 5046 100.00 Osteoarthritis 2344 100.00 Disorder Of Lipid Metabolism 1254 100.00 Rheumatoid Arthritis 894 100.00 Insulin Resistance 738 100.00 Fatty Liver 158 100.00 INFLAMMATION 10336 99.98 Leukemia 2349 99.98

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We found that co-expression of PPAR delta, retinoid X receptor (RXR) alpha, and coactivators such as CBP and SRC-1 enhanced basal and agonist-dependent activation of PPAR responsive element (PPRE)-driven transcription by PPAR delta, rendering a PPRE-driven reporter assay reliable and sensitive.

Gene_expression (expression) of PPAR associated with agonist

1) Confidence 0.78 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14646253 Disease Relevance 0.23 Pain Relevance 0.53

It has been shown that in inflammatory skin disorders, including hyperproliferative psoriatic epidermis and the skin of patients with atopic dermatitis, the expression of both PPARalpha and PPARgamma is decreased.

Gene_expression (expression) of PPARalpha in skin associated with psoriasis, inflammation and eczema

2) Confidence 0.77 Published 2008 Journal Am J Clin Dermatol Section Abstract Doc Link 18092840 Disease Relevance 1.06 Pain Relevance 0.26

This observation suggests the possibility that PPARalpha and PPARgamma activators, or compounds that positively regulate PPAR gene expression, may represent novel NSAIDs for the topical or systemic treatment of common inflammatory skin diseases such as atopic dermatitis, psoriasis, and allergic contact dermatitis.

Gene_expression (expression) of PPAR in skin associated with psoriasis, inflammation, skin diseases, cinod, dermatitis and eczema

3) Confidence 0.77 Published 2008 Journal Am J Clin Dermatol Section Abstract Doc Link 18092840 Disease Relevance 1.19 Pain Relevance 0.31

does not express PPAR?.

Neg (not) Gene_expression (express) of PPAR

4) Confidence 0.76 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 0.71 Pain Relevance 0

chosen because the first does not express PPAR?

Neg (not) Gene_expression (express) of PPAR

5) Confidence 0.76 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 0.71 Pain Relevance 0

This review will focus on the major studies dealing with PPAR expression in gliomas and neuroblastoma and the therapeutic implications of using PPAR agonists for the treatment of these neoplasms. 1.

Gene_expression (expression) of PPAR associated with neuroblastoma, cancer, agonist and glioma

6) Confidence 0.76 Published 2010 Journal PPAR Research Section Abstract Doc Link PMC2841252 Disease Relevance 1.17 Pain Relevance 0.08

, based on the characteristic nucleotide sequence [32], [33], on known similarities in tissue expression between ERR and PPAR?

Gene_expression (expression) of PPAR

7) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0

gene (PPARA) expression have the potential to modify outcomes following acute coronary ischemia in patients.

Gene_expression (expression) of PPARA associated with ischemia

8) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.98 Pain Relevance 0.14

activate PPARA expression via direct binding to PPARA promoter B (?

Gene_expression (expression) of PPARA

9) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.78 Pain Relevance 0.08

Of particular interest because of the previously established important effects of nuclear hormone receptors on PPARA expression [28], [31], was a G to A substitution located 6,862 nucleotides upstream of the major PPARA transcription start site of promoter A that disrupts a nuclear receptor half-site, designated PPARA ?

Gene_expression (expression) of PPARA

10) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0

We took advantage of an experiment of nature, a common pair of SNPs that alter PPARA promoter activity, to demonstrate that PPARA expression level helps determine outcome after myocardial infarction and unstable angina in human subjects with DM.

Gene_expression (expression) of PPARA associated with angina, diabetes mellitus and myocardial infarction

11) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.91 Pain Relevance 0.18

expression of PPAR ?

Gene_expression (expression) of PPAR

12) Confidence 0.74 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 0.84 Pain Relevance 0.37

differential expression of PPAR ?

Gene_expression (expression) of PPAR

13) Confidence 0.74 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 1.24 Pain Relevance 0.03

The adult PPAR expression patterns have been extensively established at the mRNA

Gene_expression (expression) of PPAR

14) Confidence 0.74 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0 Pain Relevance 0

The enzymes necessary to convert PGD2 into prostaglandin J2 (PGJ2) are present and coexpressed with PPAR?

Gene_expression (coexpressed) of PPAR

15) Confidence 0.74 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0 Pain Relevance 0

and modify the expression of PPAR target genes; but this hypothesis has to be

Gene_expression (expression) of PPAR

16) Confidence 0.74 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0 Pain Relevance 0

Peroxisome proliferator-activated receptor (PPAR) alpha and PPARgamma (not PPARbeta) were expressed in HASM cells.

Gene_expression (expressed) of PPAR in HASM

17) Confidence 0.71 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12517972 Disease Relevance 0.15 Pain Relevance 0.39

Cotransfection with the PPARalpha and retinoid X receptor-alpha expression vectors and subsequent treatment with the PPARalpha agonist led to the suppression of the UGDH promoter activity either in the presence or absence of rifampicin.

Gene_expression (Cotransfection) of PPARalpha associated with agonist

18) Confidence 0.71 Published 2005 Journal J. Biochem. Mol. Toxicol. Section Abstract Doc Link 16292757 Disease Relevance 0.06 Pain Relevance 0.12

Overexpression of PPAR?

Gene_expression (Overexpression) of PPAR

19) Confidence 0.70 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 0.65 Pain Relevance 0.07

The expression of PPAR?

Gene_expression (expression) of PPAR

20) Confidence 0.67 Published 2005 Journal Respir Res Section Body Doc Link PMC1298337 Disease Relevance 0.44 Pain Relevance 0.03

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