INT86024

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2011
Negated 16
Speculated 20
Reported most in Body
Documents 736
Total Number 756
Disease Relevance 497.93
Pain Relevance 91.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
liver 14
adipocytes 11
macrophages 7
adipose tissue 6
colon 4
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 11435 100.00 Very High Very High Very High
Osteoarthritis 2309 100.00 Very High Very High Very High
cINOD 1709 100.00 Very High Very High Very High
dexamethasone 311 100.00 Very High Very High Very High
Endocannabinoid 150 100.00 Very High Very High Very High
Inflammation 8630 99.98 Very High Very High Very High
COX2 266 99.98 Very High Very High Very High
antagonist 1592 99.84 Very High Very High Very High
ischemia 418 99.70 Very High Very High Very High
Adalimumab 365 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 12983 100.00 Very High Very High Very High
Obesity 10140 100.00 Very High Very High Very High
Diabetes Mellitus 5046 100.00 Very High Very High Very High
Osteoarthritis 2344 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 1254 100.00 Very High Very High Very High
Rheumatoid Arthritis 894 100.00 Very High Very High Very High
Insulin Resistance 738 100.00 Very High Very High Very High
Fatty Liver 158 100.00 Very High Very High Very High
INFLAMMATION 10336 99.98 Very High Very High Very High
Leukemia 2349 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that co-expression of PPAR delta, retinoid X receptor (RXR) alpha, and coactivators such as CBP and SRC-1 enhanced basal and agonist-dependent activation of PPAR responsive element (PPRE)-driven transcription by PPAR delta, rendering a PPRE-driven reporter assay reliable and sensitive.
Gene_expression (expression) of PPAR associated with agonist
1) Confidence 0.78 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14646253 Disease Relevance 0.23 Pain Relevance 0.53
It has been shown that in inflammatory skin disorders, including hyperproliferative psoriatic epidermis and the skin of patients with atopic dermatitis, the expression of both PPARalpha and PPARgamma is decreased.
Gene_expression (expression) of PPARalpha in skin associated with psoriasis, inflammation and eczema
2) Confidence 0.77 Published 2008 Journal Am J Clin Dermatol Section Abstract Doc Link 18092840 Disease Relevance 1.06 Pain Relevance 0.26
This observation suggests the possibility that PPARalpha and PPARgamma activators, or compounds that positively regulate PPAR gene expression, may represent novel NSAIDs for the topical or systemic treatment of common inflammatory skin diseases such as atopic dermatitis, psoriasis, and allergic contact dermatitis.
Gene_expression (expression) of PPAR in skin associated with psoriasis, inflammation, skin diseases, cinod, dermatitis and eczema
3) Confidence 0.77 Published 2008 Journal Am J Clin Dermatol Section Abstract Doc Link 18092840 Disease Relevance 1.19 Pain Relevance 0.31
does not express PPAR?.
Neg (not) Gene_expression (express) of PPAR
4) Confidence 0.76 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 0.71 Pain Relevance 0
chosen because the first does not express PPAR?
Neg (not) Gene_expression (express) of PPAR
5) Confidence 0.76 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 0.71 Pain Relevance 0
This review will focus on the major studies dealing with PPAR expression in gliomas and neuroblastoma and the therapeutic implications of using PPAR agonists for the treatment of these neoplasms.


1.

Gene_expression (expression) of PPAR associated with neuroblastoma, cancer, agonist and glioma
6) Confidence 0.76 Published 2010 Journal PPAR Research Section Abstract Doc Link PMC2841252 Disease Relevance 1.17 Pain Relevance 0.08
, based on the characteristic nucleotide sequence [32], [33], on known similarities in tissue expression between ERR and PPAR?
Gene_expression (expression) of PPAR
7) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
gene (PPARA) expression have the potential to modify outcomes following acute coronary ischemia in patients.
Gene_expression (expression) of PPARA associated with ischemia
8) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.98 Pain Relevance 0.14
activate PPARA expression via direct binding to PPARA promoter B (?
Gene_expression (expression) of PPARA
9) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.78 Pain Relevance 0.08
Of particular interest because of the previously established important effects of nuclear hormone receptors on PPARA expression [28], [31], was a G to A substitution located 6,862 nucleotides upstream of the major PPARA transcription start site of promoter A that disrupts a nuclear receptor half-site, designated PPARA ?
Gene_expression (expression) of PPARA
10) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
We took advantage of an experiment of nature, a common pair of SNPs that alter PPARA promoter activity, to demonstrate that PPARA expression level helps determine outcome after myocardial infarction and unstable angina in human subjects with DM.
Gene_expression (expression) of PPARA associated with angina, diabetes mellitus and myocardial infarction
11) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.91 Pain Relevance 0.18
expression of PPAR ?
Gene_expression (expression) of PPAR
12) Confidence 0.74 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 0.84 Pain Relevance 0.37
differential expression of PPAR ?
Gene_expression (expression) of PPAR
13) Confidence 0.74 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 1.24 Pain Relevance 0.03
The adult PPAR expression patterns have been extensively established at the mRNA
Gene_expression (expression) of PPAR
14) Confidence 0.74 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0 Pain Relevance 0
The enzymes necessary to convert PGD2 into prostaglandin J2 (PGJ2) are present and coexpressed with PPAR?
Gene_expression (coexpressed) of PPAR
15) Confidence 0.74 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0 Pain Relevance 0
and modify the expression of PPAR target genes; but this hypothesis has to be
Gene_expression (expression) of PPAR
16) Confidence 0.74 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0 Pain Relevance 0
Peroxisome proliferator-activated receptor (PPAR) alpha and PPARgamma (not PPARbeta) were expressed in HASM cells.
Gene_expression (expressed) of PPAR in HASM
17) Confidence 0.71 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12517972 Disease Relevance 0.15 Pain Relevance 0.39
Cotransfection with the PPARalpha and retinoid X receptor-alpha expression vectors and subsequent treatment with the PPARalpha agonist led to the suppression of the UGDH promoter activity either in the presence or absence of rifampicin.
Gene_expression (Cotransfection) of PPARalpha associated with agonist
18) Confidence 0.71 Published 2005 Journal J. Biochem. Mol. Toxicol. Section Abstract Doc Link 16292757 Disease Relevance 0.06 Pain Relevance 0.12
Overexpression of PPAR?
Gene_expression (Overexpression) of PPAR
19) Confidence 0.70 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 0.65 Pain Relevance 0.07
The expression of PPAR?
Gene_expression (expression) of PPAR
20) Confidence 0.67 Published 2005 Journal Respir Res Section Body Doc Link PMC1298337 Disease Relevance 0.44 Pain Relevance 0.03

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