INT86025

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Context Info
Confidence 0.52
First Reported 2000
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 34
Total Number 37
Disease Relevance 22.89
Pain Relevance 5.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
corneal epithelial cells 4
fat 2
platelet 2
lung 2
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 514 99.84 Very High Very High Very High
Inflammation 483 98.48 Very High Very High Very High
cINOD 74 95.40 Very High Very High Very High
Serotonin 2 95.28 Very High Very High Very High
Inflammatory response 53 94.76 High High
cytokine 74 93.88 High High
Analgesic 1 92.16 High High
antagonist 60 91.20 High High
Pain 7 86.24 High High
bradykinin 8 76.56 Quite High
Disease Link Frequency Relevance Heat
Colorectal Cancer 50 99.96 Very High Very High Very High
Hypoxia 40 99.84 Very High Very High Very High
Pre-eclampsia 5 99.60 Very High Very High Very High
Cancer 1002 99.44 Very High Very High Very High
Disease 182 99.28 Very High Very High Very High
Inflammatory Bowel Disease 31 99.04 Very High Very High Very High
INFLAMMATION 564 98.16 Very High Very High Very High
Hyperglycemia 109 98.12 Very High Very High Very High
Gastrointestinal Neoplasms 16 96.52 Very High Very High Very High
Apoptosis 457 96.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
not result in activation of PPAR?
Neg (not) Positive_regulation (result) of Positive_regulation (activation) of PPAR
1) Confidence 0.52 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.04 Pain Relevance 0.40
is mostly known for its ability to induce fatty acid oxidation, growing evidence points to a role of PPAR?
Positive_regulation (points) of Positive_regulation (role) of PPAR
2) Confidence 0.49 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.09 Pain Relevance 0.13
activation to induction of specific PPAR?
Positive_regulation (activation) of Positive_regulation (induction) of PPAR
3) Confidence 0.49 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.14 Pain Relevance 0.07
Fenofibric acid derivatives exert their primary effects on lipid metabolism via the activation of peroxisome proliferator-activated receptor-alpha (PPAR-?)
Positive_regulation (derivatives) of Positive_regulation (activation) of PPAR
4) Confidence 0.49 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 0.08 Pain Relevance 0.09
It is postulated that activation of PPAR?
Positive_regulation (postulated) of Spec (postulated) Positive_regulation (activation) of PPAR
5) Confidence 0.48 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 0.83 Pain Relevance 0.60
The potential involvement of PPAR?
Positive_regulation (potential) of Positive_regulation (involvement) of PPAR
6) Confidence 0.48 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0.46 Pain Relevance 0.04
One possible explanation for the antagonistic role of PPAR?
Positive_regulation (explanation) of Positive_regulation (role) of PPAR
7) Confidence 0.45 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 1.39 Pain Relevance 0.34
Rosiglitazone increased the activation of PPAR?
Positive_regulation (increased) of Positive_regulation (activation) of PPAR
8) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.12
Each drug produced a concentration-dependent activation of the PPAR isoforms and fatty acid beta-oxidase activity, inhibition of human arachidonic acid-induced platelet aggregation and serotonin secretion, and inhibition of PGHS-1 and PGHS-2 activities.
Positive_regulation (produced) of Positive_regulation (activation) of PPAR in platelet associated with serotonin
9) Confidence 0.43 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11755111 Disease Relevance 0.08 Pain Relevance 0.20
were identified in a subset of human colorectal tumors, supporting a role for PPAR?
Positive_regulation (supporting) of Positive_regulation (role) of PPAR associated with colorectal cancer
10) Confidence 0.42 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 1.54 Pain Relevance 0.03
It is now widely accepted that activation of PPAR?
Positive_regulation (accepted) of Positive_regulation (activation) of PPAR
11) Confidence 0.42 Published 2009 Journal PPAR Research Section Body Doc Link PMC2770108 Disease Relevance 1.14 Pain Relevance 0.57
Many in vitro studies have showed that ligand-induced activation of PPAR?
Positive_regulation (induced) of Positive_regulation (activation) of PPAR
12) Confidence 0.42 Published 2009 Journal PPAR Research Section Abstract Doc Link PMC2770108 Disease Relevance 0.70 Pain Relevance 0.08
target genes such as Cd36 were also induced by TRO treatment in lean mice without induction of PPAR?
Positive_regulation (induced) of Neg (without) Positive_regulation (induction) of PPAR
13) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2963138 Disease Relevance 1.07 Pain Relevance 0
The lack of Tusc5 induction in HepG2 cells contrasted with a variety of PPAR target genes that were induced under conditions of PPAR activation (Table 1).
Positive_regulation (induced) of Positive_regulation (activation) of PPAR
14) Confidence 0.40 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.59 Pain Relevance 0.09
mRNA expression in skeletal muscle in control chow-fed animals, and in fat-fed rats exercise counteracted the diet-induced increase of PPAR?
Positive_regulation (induced) of Positive_regulation (increase) of PPAR in fat
15) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0 Pain Relevance 0.16
ligands exert antitumor properties did not determine whether the effects required ligand activation of the PPAR?
Positive_regulation (required) of Positive_regulation (activation) of PPAR
16) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.45 Pain Relevance 0.12
This inhibitory complex is adipogenesis stage-dependent, such that earlier in adipogenesis (i.e., at Day 4), hyperphosphorylation of RB minimizes complex formation (thus enabling maximal PPAR?
Positive_regulation (enabling) of Positive_regulation (maximal) of PPAR
17) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.38 Pain Relevance 0.03
therefore contributes to the enhancement of PPAR?
Positive_regulation (contributes) of Positive_regulation (enhancement) of PPAR
18) Confidence 0.34 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.58 Pain Relevance 0.03
Fenofibric acid derivatives exert their primary effects on lipid metabolism via the activation of peroxisome proliferator-activated receptor-alpha (PPAR-?)
Positive_regulation (derivatives) of Positive_regulation (activation) of peroxisome proliferator-activated receptor-alpha
19) Confidence 0.34 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922314 Disease Relevance 0.08 Pain Relevance 0.09
It will also be important to determine whether the therapeutic effects of PPAR?
Positive_regulation (important) of Positive_regulation (effects) of PPAR
20) Confidence 0.33 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.79 Pain Relevance 0.12

General Comments

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