INT8603

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 1983
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 28
Total Number 28
Disease Relevance 1.42
Pain Relevance 7.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
neuronal 2
ileum 1
blood 1
intrinsic neurons 1
brain 1
Mme (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 52 100.00 Very High Very High Very High
Neuropeptide 14 99.44 Very High Very High Very High
addiction 2 99.26 Very High Very High Very High
substance P 11 99.00 Very High Very High Very High
antagonist 5 98.88 Very High Very High Very High
Potency 11 98.56 Very High Very High Very High
Intracerebroventricular 2 98.52 Very High Very High Very High
Eae 2 97.00 Very High Very High Very High
Substantia nigra 10 96.16 Very High Very High Very High
drug abuse 3 95.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Drug Dependence 4 99.26 Very High Very High Very High
Stress 7 98.88 Very High Very High Very High
Anxiety Disorder 3 96.80 Very High Very High Very High
Neuroblastoma 1 91.68 High High
Ganglion Cysts 3 86.40 High High
Natriuresis 2 82.40 Quite High
Reprotox - General 2 3 79.68 Quite High
Pain 1 79.60 Quite High
Alcohol Addiction 1 60.12 Quite High
Opiate Addiction 1 49.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitory potencies of a series of systematically varied oligopeptides regarding [3H]thiorphan binding and enkephalinase activity were also highly correlated.
enkephalinase Binding (binding) of
1) Confidence 0.48 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3165067 Disease Relevance 0 Pain Relevance 0.08
Immunoperoxidase cytochemistry confirmed the association of immunoreactive enkephalinase with the plasma membrane of neurons and, to a lesser extent, of astrocytes and oligodendrocytes.
enkephalinase Binding (association) of in oligodendrocytes
2) Confidence 0.48 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 2201754 Disease Relevance 0 Pain Relevance 0.07
It is generally assumed that enkephalinase A, a highly thiorphan-sensitive dipeptidylcarboxypeptidase cleaving the Gly-Phe bond during enkephalin degradation, is bound to the neuronal membrane.
enkephalinase Binding (bound) of in neuronal associated with enkephalin
3) Confidence 0.48 Published 1983 Journal Life Sci. Section Abstract Doc Link 6363850 Disease Relevance 0.09 Pain Relevance 0.17
Despite the similarities in their mechanism of action, the structural requirements for selective interaction with angiotensin-converting enzyme or enkephalinase are different.
enkephalinase Binding (interaction) of
4) Confidence 0.48 Published 1984 Journal Eur. J. Biochem. Section Abstract Doc Link 6321177 Disease Relevance 0 Pain Relevance 0.12
Differences in the structural requirements for selective interaction with neutral metalloendopeptidase (enkephalinase) or angiotensin-converting enzyme.
enkephalinase Binding (interaction) of
5) Confidence 0.48 Published 1984 Journal Eur. J. Biochem. Section Title Doc Link 6321177 Disease Relevance 0 Pain Relevance 0.12
The protein is recognized both by specific anti-Aplysia NEP (apNEP) antibodies and by the [125I]-labeled NEP-specific inhibitor RB104, demonstrating that the apNEP gene codes for the RB104-binding protein.
NEP Binding (recognized) of
6) Confidence 0.38 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10341232 Disease Relevance 0.06 Pain Relevance 0.12
The size and morphology of the cell types associated with the enzyme supported a neuronal association for enkephalinase.
enkephalinase Binding (association) of in neuronal
7) Confidence 0.37 Published 1989 Journal J. Comp. Neurol. Section Abstract Doc Link 2918102 Disease Relevance 0 Pain Relevance 0.30
When associated with the enkephalinase inhibitor thiorphan (50 micrograms, intracerebroventricular) it decreased locomotor activity.
enkephalinase Binding (associated) of associated with eae and intracerebroventricular
8) Confidence 0.37 Published 1990 Journal Peptides Section Abstract Doc Link 2381875 Disease Relevance 0 Pain Relevance 0.29
A number of other areas appear richly endowed in both enkephalinase and enkephalins whereas substance P is hardly detectable.
enkephalinase Binding (endowed) of associated with enkephalin and substance p
9) Confidence 0.37 Published 1989 Journal Neuroscience Section Abstract Doc Link 2473416 Disease Relevance 0.08 Pain Relevance 0.99
Association of the enkephalinase gene with low amplitude P300 waves.
enkephalinase Binding (Association) of
10) Confidence 0.34 Published 1999 Journal Neuroreport Section Title Doc Link 10439449 Disease Relevance 0.27 Pain Relevance 0.29
Degrading enzymes such as enkephalinase and oxytocinase could also be associated with this response.
enkephalinase Binding (associated) of
11) Confidence 0.34 Published 2009 Journal Neuropsychobiology Section Abstract Doc Link 19468242 Disease Relevance 0.37 Pain Relevance 0.24
The protein is recognized both by specific anti-Aplysia NEP (apNEP) antibodies and by the [125I]-labeled NEP-specific inhibitor RB104, demonstrating that the apNEP gene codes for the RB104-binding protein.
apNEP Binding (recognized) of
12) Confidence 0.32 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10341232 Disease Relevance 0.06 Pain Relevance 0.12
The inhibitory potency of the various inhibitors indicates that, in the thiorphan series, the affinity for enkephalinase is independent of the stereochemistry of the 2-(mercaptomethyl)-1-oxo-3-phenylpropyl moiety.
enkephalinase Binding (affinity) of associated with potency
13) Confidence 0.32 Published 1986 Journal J. Med. Chem. Section Abstract Doc Link 3517331 Disease Relevance 0 Pain Relevance 0.13
This feature could mean that optimal binding of the Zn atom present in the catalytic site is a more stringent requirement in angiotensin-converting enzyme than in enkephalinase.
enkephalinase Binding (binding) of
14) Confidence 0.32 Published 1984 Journal Eur. J. Biochem. Section Abstract Doc Link 6321177 Disease Relevance 0.08 Pain Relevance 0.24
Taken together these data suggest that NEP is in part associated with striatal intrinsic neurons.
NEP Binding (associated) of in intrinsic neurons
15) Confidence 0.31 Published 1987 Journal Brain Res. Section Abstract Doc Link 2829989 Disease Relevance 0 Pain Relevance 0.70
Immunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis studies of radiolabeled brush border proteins indicate that mAb 85A2 binds specifically an antigen with an apparent molecular weight of 90 kilodaltons, corresponding to published values for enkephalinase.
enkephalinase Binding (binds) of in brush
16) Confidence 0.30 Published 1988 Journal Lab. Invest. Section Abstract Doc Link 3276960 Disease Relevance 0 Pain Relevance 0.09
Compounds lacking the carboxy terminal side-chain are not recognized by enkephalinase B or aminopeptidase but are potent inhibitors of enkephalinase A.
enkephalinase Binding (recognized) of
17) Confidence 0.28 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3556201 Disease Relevance 0 Pain Relevance 0.19
More generally, the presence of apNEP in the CNS and periphery may indicate that it could play a major role in the modulation of synaptic transmission in Aplysia and in the metabolism of neuropeptides close to their point of release.
apNEP Binding (presence) of associated with neuropeptide
18) Confidence 0.28 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10341232 Disease Relevance 0.09 Pain Relevance 0.14
In tissues and cells NEP is bound to plasma membrane through a hydrophobic membrane-spanning domain near the NH2 terminus, but it is present in soluble form in urine and blood.
NEP Binding (bound) of in blood
19) Confidence 0.26 Published 1989 Journal FASEB J. Section Abstract Doc Link 2521610 Disease Relevance 0.08 Pain Relevance 0.40
These peptides are quickly metabolized by enkephalinase and angiotensin converting enzyme (ACE).
enkephalinase Binding (metabolized) of
20) Confidence 0.26 Published 1986 Journal Neuropeptides Section Abstract Doc Link 3020471 Disease Relevance 0 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox