INT86036

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Context Info
Confidence 0.35
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.42
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Ddc) intracellular (Ddc) cellular amino acid metabolic process (Ddc)
cytoplasm (Ddc)
Anatomy Link Frequency
striatum 2
Ddc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 47 99.98 Very High Very High Very High
agonist 1 91.80 High High
fluoxetine 4 90.24 High High
medulla 12 88.00 High High
Hippocampus 12 87.24 High High
Serotonin 1 75.00 Quite High
Potency 5 72.48 Quite High
Substantia nigra 9 5.00 Very Low Very Low Very Low
Opioid receptor 1 7 5.00 Very Low Very Low Very Low
dopamine receptor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 12 86.48 High High
Dyskinesias 34 85.08 High High
Congenital Anomalies 3 58.40 Quite High
Parkinson's Disease 6 50.00 Quite Low
Disease 21 18.96 Low Low
Hyperkinesis 5 5.00 Very Low Very Low Very Low
Tremor 2 5.00 Very Low Very Low Very Low
Thyroid Disease 2 5.00 Very Low Very Low Very Low
Hyperthyroidism 2 5.00 Very Low Very Low Very Low
Dystonia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The synthesis of 5-HT was assessed by measuring the accumulation of 5-hydroxytryptophan (5-HTP) after blockade of aromatic amino acid decarboxylase induced by m-hydroxybenzylhydrazine (NSD-1015), at 100 mg/kg i.p., 30 min before sacrifice.
Negative_regulation (blockade) of Positive_regulation (induced) of aromatic amino acid decarboxylase
1) Confidence 0.35 Published 1999 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 10647099 Disease Relevance 0.28 Pain Relevance 0.63
PreproTRH mRNA levels in the dopamine-depleted striatum of the L-DOPA-treated animals were positively correlated with the behavioral scores (Pearson's r ?
Negative_regulation (depleted) of Positive_regulation (striatum) of L-DOPA in striatum associated with dopamine
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.14 Pain Relevance 0.17

General Comments

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