INT86049

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Context Info
Confidence 0.09
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.94
Pain Relevance 5.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CeA 1
D2Mit212 (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 62 99.80 Very High Very High Very High
amygdala 17 99.26 Very High Very High Very High
Morphine 45 98.92 Very High Very High Very High
potassium channel 1 98.04 Very High Very High Very High
agonist 65 97.56 Very High Very High Very High
Dorsal horn 2 97.24 Very High Very High Very High
Spinal cord 4 96.76 Very High Very High Very High
Cannabinoid 78 96.24 Very High Very High Very High
Pain 9 92.88 High High
Glutamate 8 87.64 High High
Disease Link Frequency Relevance Heat
Bordatella Infection 5 93.28 High High
Pain 6 92.88 High High
Nociception 4 92.12 High High
Urological Neuroanatomy 20 80.88 Quite High
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Hypothermia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A lower dose, 0.25 microg, decreased the E(max) of WIN55,212-2 by 70% but did not significantly affect its EC(50).
Negative_regulation (decreased) of WIN55,212-2
1) Confidence 0.09 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17644088 Disease Relevance 0.09 Pain Relevance 0.36
WIN55,212-2 diminished the analgesic response of morphine, and this reduction was observed even after 5 days of icv cannabinoid injection.
Negative_regulation (diminished) of WIN55,212-2 associated with cannabinoid, analgesic and morphine
2) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 1.62
Interestingly, the reduction of KCl- and 4AP-evoked release by WIN55,212-2 was independent of adenylylcyclase activity and did not affect cAMP.
Negative_regulation (reduction) of WIN55,212-2
3) Confidence 0.03 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15755482 Disease Relevance 0 Pain Relevance 0.54
In rats treated with intra-CeA muscimol, however, these effects of WIN55,212-2 were significantly reduced.
Negative_regulation (reduced) of WIN55,212-2 in CeA associated with amygdala
4) Confidence 0.03 Published 2003 Journal Neuroscience Section Abstract Doc Link 12927220 Disease Relevance 0.27 Pain Relevance 1.57
The WIN55,212-2-induced decrease in miniature inhibitory postsynaptic current rate was concentration dependent (EC(50) = 520 nM).
Negative_regulation (decrease) of WIN55,212-2
5) Confidence 0.00 Published 2000 Journal Mol. Pharmacol. Section Abstract Doc Link 10648638 Disease Relevance 0.58 Pain Relevance 0.91

General Comments

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