INT86060

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Context Info
Confidence 0.64
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 3.04
Pain Relevance 6.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Fst) nucleus (Fst) cellular_component (Fst)
cytoplasm (Fst)
Anatomy Link Frequency
NAcc 1
Fst (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 59 100.00 Very High Very High Very High
Dopamine 217 99.62 Very High Very High Very High
fluoxetine 120 99.56 Very High Very High Very High
amygdala 125 99.10 Very High Very High Very High
Raphe 7 98.60 Very High Very High Very High
antidepressant 219 98.48 Very High Very High Very High
agonist 93 98.22 Very High Very High Very High
antagonist 48 97.36 Very High Very High Very High
noradrenaline 10 96.02 Very High Very High Very High
Nucleus accumbens 30 95.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 178 100.00 Very High Very High Very High
Anxiety Disorder 97 99.54 Very High Very High Very High
Targeted Disruption 28 92.84 High High
Apoptosis 1 87.96 High High
Urological Neuroanatomy 5 85.28 High High
Shock 8 82.84 Quite High
Sprains And Strains 11 77.76 Quite High
Stress 71 69.56 Quite High
Body Weight 7 68.68 Quite High
Nociception 2 67.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The DA depletion-induced increases in Fst mRNA levels are consistent with those reported in a recent microarray study [44].
Positive_regulation (increases) of Fst associated with dopamine
1) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0.14 Pain Relevance 0.31
SalvA dose dependently increased immobility in the FST, an effect opposite to that of standard antidepressant drugs.
Positive_regulation (increased) of FST associated with antidepressant and eae
2) Confidence 0.56 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16223871 Disease Relevance 0.47 Pain Relevance 0.92
The observations that the small METH dose caused further increases in Fst mRNA levels on the lesioned side of 6-OHDA-treated rats suggest that these METH-induced alterations in Fst expression might be independent of METH-induced DA release.
Positive_regulation (increases) of Fst associated with dopamine
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.22
RESULTS: VLX, FLX, or DMI by themselves at these doses did not induce changes in the FST at short intervals after their injection (from 1 to 7 days).
Neg (not) Positive_regulation (induce) of FST
4) Confidence 0.42 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18795270 Disease Relevance 0 Pain Relevance 0
The serotonergic compounds, fluoxetine and 8-OH-DPAT, produced dose-dependent reductions of immobility and increases of swimming behavior in the FST in SD rats, but the response to the serotonergic drugs were blunted in WKY rats.
Positive_regulation (increases) of FST associated with fluoxetine
5) Confidence 0.41 Published 2000 Journal Neuropsychopharmacology Section Abstract Doc Link 10649831 Disease Relevance 0.29 Pain Relevance 0.39
Since alpha(2)-adrenoreceptors and 5-HT(1A)-receptors have important regulatory functions and are involved in 5-HT/NA interactions, we examined whether the alpha(2)-receptor-antagonist idazoxan and the 5-HT(1A)-receptor-agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) would modify the behavioral pattern induced in the FST by either selective or non-selective antidepressant treatments.
Positive_regulation (induced) of FST associated with antidepressant, antagonist, agonist and noradrenaline
6) Confidence 0.41 Published 2001 Journal Neuropsychopharmacology Section Abstract Doc Link 11182533 Disease Relevance 0 Pain Relevance 0.82
Conversely, systemic administration of the kappa-agonist [5alpha,7alpha,8beta]-N-methyl-N-[7-[1-pyrrolidinyl]-1-oxaspiro[4.5]dec8-yl]-benzenacetamide (U-69593) dose dependently increased immobility in the FST, consistent with prodepressant-like effects.
Positive_regulation (increased) of FST associated with eae and agonist
7) Confidence 0.40 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12649385 Disease Relevance 0.06 Pain Relevance 1.27
Results showed that allopregnanolone (intra-NAcc; 1.5 microg, p < 0.05; 2.0 microg, p < 0.05) or systemic injections of allopregnanolone (1.5 mg/kg, p < 0.05; 2.0 mg/kg, p < 0.05; s.c.) or muscimol (0.3 mg/kg, p < 0.05; 0.6 mg/kg, p < 0.05; i.p.) reduced immobility by increasing climbing in the forced swimming task (FST), whereas fluoxetine (1.0 mg/kg, p < 0.05; 2.0 mg/kg, p < 0.05; i.p.) reduced immobility by increasing swimming.
Positive_regulation (increasing) of FST in NAcc associated with nucleus accumbens and fluoxetine
8) Confidence 0.40 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15740782 Disease Relevance 0 Pain Relevance 0.77
For example, while chemical lesions of the BNST induced antidepressant-like effects in the rat learned helplessness model [16,19], electrolytic lesions of the BNST increased depressive-like behavior in the rat forced swimming test (FST) [39-41].
Positive_regulation (increased) of FST associated with antidepressant and depression
9) Confidence 0.39 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2887770 Disease Relevance 0.76 Pain Relevance 0.27
Power and initial FST was negatively correlated, with a rapid decline in power with an increasing initial FST.
Positive_regulation (increasing) of FST
10) Confidence 0.37 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2942893 Disease Relevance 0 Pain Relevance 0
These changes included an increase of immobile time and ambulation counts in the FST and OFT tests, respectively.
Positive_regulation (increase) of FST
11) Confidence 0.24 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518376 Disease Relevance 0.31 Pain Relevance 0.08
Immobility time in FST was derived from the number of frames (every 40 ms) being below a predefined threshold over FST duration.
Positive_regulation (derived) of FST
12) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821932 Disease Relevance 0 Pain Relevance 0.15
Furthermore, as the beta weights show in Figure 4, specifically in the BLA lesion group, anxiety indirectly related to increased FST immobility via opposite regulation of Ki67 and BrdU (total and indirect effect breakdown, see Table S5).
Positive_regulation (increased) of FST associated with anxiety disorder and amygdala
13) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799663 Disease Relevance 0.59 Pain Relevance 0.67
Maternal separation induced increased immobility in rat FST was mediated by decreased hippocampal 5-HT and raphe expression of 5-HTT mRNA [162].
Positive_regulation (mediated) of FST associated with eae and raphe
14) Confidence 0.16 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.42 Pain Relevance 0.46

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