INT86062

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 51
Total Number 51
Disease Relevance 40.69
Pain Relevance 26.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf1a) extracellular space (Tnfrsf1a) extracellular region (Tnfrsf1a)
plasma membrane (Tnfrsf1a) nucleus (Tnfrsf1a) protein complex (Tnfrsf1a)
Anatomy Link Frequency
neurons 9
cerebellum 2
nerve 2
plasma 1
R1-2 1
Tnfrsf1a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 750 100.00 Very High Very High Very High
cytokine 153 100.00 Very High Very High Very High
antagonist 119 100.00 Very High Very High Very High
metalloproteinase 12 100.00 Very High Very High Very High
Eae 26 99.96 Very High Very High Very High
dorsal root ganglion 1106 99.84 Very High Very High Very High
qutenza 1342 99.82 Very High Very High Very High
Arthritis 30 99.66 Very High Very High Very High
ischemia 28 99.08 Very High Very High Very High
Migraine 10 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 847 100.00 Very High Very High Very High
Cancer 201 100.00 Very High Very High Very High
Necrosis 100 100.00 Very High Very High Very High
Adhesions 24 100.00 Very High Very High Very High
Nervous System Injury 94 99.98 Very High Very High Very High
Injury 128 99.96 Very High Very High Very High
Ganglion Cysts 1137 99.84 Very High Very High Very High
Nociception 156 99.84 Very High Very High Very High
Coronary Artery Disease 29 99.84 Very High Very High Very High
Neurodegenerative Disease 72 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unlike TNFR1, TNFR2 was markedly upregulated already on day 1 after crush or CCI.
Positive_regulation (upregulated) of TNFR1 associated with eae
1) Confidence 0.69 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15698630 Disease Relevance 1.09 Pain Relevance 0.48
TNFR1 is increased in nociceptive DRG neurons and primary afferents by intraperitoneal lipopolysaccharide and after nerve injury in animal models, and in plasma of patients with pain syndromes, supporting an important role for TNFR1 in nociception [17-19].
Positive_regulation (increased) of TNFR1 in plasma associated with nociception, pain, dorsal root ganglion, nervous system injury and syndrome
2) Confidence 0.66 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 1.97 Pain Relevance 1.15
In the present study using mouse DRG neuronal cultures, TNFR1 was significantly increased after stimulation with capsaicin/resiniferatoxin.
Positive_regulation (increased) of TNFR1 in neuronal associated with dorsal root ganglion and qutenza
3) Confidence 0.66 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.88 Pain Relevance 0.68
PBN blocks capsaicin induced TNFR1 increases
Positive_regulation (increases) of TNFR1 associated with qutenza
4) Confidence 0.66 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.86 Pain Relevance 0.73
In CFA arthritis models in vivo, upregulation of TNFR1 receptors is detected in peripheral joint tissue, DRG neurons, and small fiber bundles within the root entry zone and fibers bordering the trigeminal and spinal cord dorsal horn [28,34,35].
Positive_regulation (upregulation) of TNFR1 in spinal cord dorsal horn associated with dorsal root ganglion, dorsal horn, spinal cord and arthritis
5) Confidence 0.66 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.89 Pain Relevance 1.04
PBN blocks capsaicin induced TNFR1 increase in DRG neurons of wild type mice
Positive_regulation (increase) of TNFR1 in neurons associated with dorsal root ganglion and qutenza
6) Confidence 0.66 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.66 Pain Relevance 1.20
In our experiment, blocking ROS production also abolished TNFR1 increases.
Positive_regulation (increases) of TNFR1
7) Confidence 0.66 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.39 Pain Relevance 0.36
Significant increases in TNFR1 are relevant based on behavioral evidence showing that antibody against TNFR1 applied to the epineuria abolishes hyperalgesia caused by chronic constriction nerve injury [14].
Positive_regulation (increases) of TNFR1 in nerve associated with hyperalgesia and nervous system injury
8) Confidence 0.66 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 1.26 Pain Relevance 0.86
Accumulation of mutant TNFR1 in the ER may trigger the ER stress response, which could directly or indirectly lead to inflammation.
Positive_regulation (Accumulation) of TNFR1 associated with stress and inflammation
9) Confidence 0.48 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206363 Disease Relevance 1.12 Pain Relevance 0.09
M, 10 min) blocked TNFR1 increases induced by capsaicin (1 ?
Positive_regulation (increases) of TNFR1 associated with qutenza
10) Confidence 0.48 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.60 Pain Relevance 1.20
The interactive relationship of these two types of receptors will be the target of further investigation since the present study suggests TRPV1 activation is inducing TNFR1 increases and/or activation.
Positive_regulation (increases) of TNFR1
11) Confidence 0.48 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.85 Pain Relevance 0.62
To confirm that TNFR1 increases induced by capsaicin are mediated through TRPV1, TRPV1 knockout mice were employed and additional experiments using capsazepine were also performed.
Positive_regulation (increases) of TNFR1 associated with targeted disruption and qutenza
12) Confidence 0.48 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.84 Pain Relevance 0.87
M, 20 min) and resiniferatoxin (200 nM, 20 min) treated groups had significantly increased TNFR1 staining (capsaicin treated group: 14.62 ± 0.72%, n = 431, P < 0.05; resiniferatoxin treated group: 16.5 ± 1.37%, n = 622, P < 0.01), compared with the untreated group (Fig. 2A, B).
Positive_regulation (increased) of TNFR1 associated with qutenza
13) Confidence 0.48 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.46 Pain Relevance 0.75
Capsazepine, a competitive TRPV1 antagonist, was used to determine if capsaicin or resiniferatoxin induced TNFR1 staining in cultured DRG neurons from wild type mice is mediated through TRPV1 receptor activation.
Positive_regulation (induced) of TNFR1 in neurons associated with dorsal root ganglion, qutenza and antagonist
14) Confidence 0.48 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.62 Pain Relevance 1.20
This novel finding of capsaicin induced TNFR1 increases in cultured mouse DRG neurons has not been reported by other investigators.
Positive_regulation (increases) of TNFR1 in neurons associated with dorsal root ganglion and qutenza
15) Confidence 0.48 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.73 Pain Relevance 0.93
Pretreatment with PBN (2 mM, 90 min) of cultured DRG neurons from wild type mice blocked the TNFR1 increases induced by capsaicin (1 ?
Positive_regulation (increases) of TNFR1 in neurons associated with dorsal root ganglion and qutenza
16) Confidence 0.48 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.67 Pain Relevance 1.14
After crush or CCI, TNFR1 increased by 2-fold on days 3 and day 7.
Positive_regulation (increased) of TNFR1 associated with eae
17) Confidence 0.46 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15698630 Disease Relevance 1.09 Pain Relevance 0.48
The present study demonstrates the mechanistic linkage between TNFR1 and TRPV1 activation.
Positive_regulation (activation) of TNFR1
18) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 1.17 Pain Relevance 0.90
Capsazepine blocks capsaicin induced TNFR1 increase in DRG neurons from wild type mice
Positive_regulation (increase) of TNFR1 in neurons associated with dorsal root ganglion and qutenza
19) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.59 Pain Relevance 1.13
The present study shows PBN blocks TNFR1 increases induced by capsaicin.
Positive_regulation (increases) of TNFR1 associated with qutenza
20) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2706230 Disease Relevance 0.61 Pain Relevance 0.54

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