INT86082

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.73
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.77
Pain Relevance 3.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Htr1b) plasma membrane (Htr1b) cytoplasm (Htr1b)
signal transducer activity (Htr1b)
Anatomy Link Frequency
neurons 1
Htr1b (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 11 100.00 Very High Very High Very High
Serotonin 34 99.76 Very High Very High Very High
Glutamate 62 99.66 Very High Very High Very High
Neuropeptide 1 99.48 Very High Very High Very High
substance P 3 99.36 Very High Very High Very High
central sensitization 1 98.56 Very High Very High Very High
trigeminal ganglion 11 98.04 Very High Very High Very High
Inflammation 3 97.52 Very High Very High Very High
dorsal root ganglion 4 96.64 Very High Very High Very High
nociceptor 2 94.28 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 6 99.96 Very High Very High Very High
Ganglion Cysts 26 98.04 Very High Very High Very High
Neurogenic Inflammation 1 97.52 Very High Very High Very High
Increased Venous Pressure Under Development 1 96.52 Very High Very High Very High
Headache 53 88.20 High High
Nociception 14 85.16 High High
Pain 11 76.64 Quite High
Nervous System Injury 1 69.44 Quite High
Neuropathic Pain 2 68.92 Quite High
INFLAMMATION 2 68.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As both glutamate and CGRP are co-localized with 5-HT1B, 5-HT1D and/or 5-HT1F receptors in trigeminal neurons [12,13] it was suggested that the release of glutamate may be regulated in a similar manner by 5-HT1 receptor activation.
Localization (localized) of 5-HT1B in neurons associated with glutamate
1) Confidence 0.73 Published 2008 Journal Mol Pain Section Body Doc Link PMC2359740 Disease Relevance 0.94 Pain Relevance 1.50
Furthermore, the co-localization of 5-HT1B receptors with substance P was also identified in the human TG [58].
Localization (localization) of 5-HT1B associated with trigeminal ganglion and substance p
2) Confidence 0.68 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 1.64 Pain Relevance 1.22
5-HT1B receptors modulate release of [3H]dopamine from rat striatal synaptosomes: further evidence using 5-HT moduline, polyclonal 5-HT1B receptor antibodies and 5-HT1B receptor knock-out mice.
Localization (release) of 5-HT1B receptor associated with targeted disruption, dopamine and neuropeptide
3) Confidence 0.58 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 10651141 Disease Relevance 0.18 Pain Relevance 0.43
Serotonin receptors (5HT1B) are localized in all RGCs axon terminals (Salichon et al, 2001).
Localization (localized) of 5HT1B associated with serotonin
4) Confidence 0.03 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox