INT86087

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Context Info
Confidence 0.28
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Foxm1) embryo development (Foxm1) DNA binding (Foxm1)
transcription factor binding (Foxm1) cytoplasm (Foxm1)
Anatomy Link Frequency
cortex 2
Foxm1 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 2 94.44 High High
Neuropeptide 1 88.24 High High
agonist 2 80.96 Quite High
Cannabinoid receptor 4 80.64 Quite High
Serotonin 5 75.92 Quite High
Cannabinoid 2 75.00 Quite High
antagonist 1 72.12 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
WIN 55,212-2 (1 microM) inhibited the electrically evoked tritium overflow from mouse brain cortex slices preincubated with [3H]choline by 49%. [3H]WIN 55,212-2 binding to mouse cortex membranes was inhibited by CP-55,940, SR 141716 and WIN 55,212-2 (pKi=9.30, 8.70 and 8.19, respectively) but not by the auxiliary drugs indalpine, metitepine and tetrodotoxin (pKi<4.5). [35S]GTPgammaS binding was increased by WIN 55,212-2 (maximum effect of 80%, pEC50=6.94) but not affected by WIN 55,212-3.
Negative_regulation (inhibited) of WIN Binding (binding) of in cortex associated with tetrodotoxin
1) Confidence 0.28 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10651142 Disease Relevance 0 Pain Relevance 0.52

General Comments

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