INT86092

Context Info Confidence 0.78 First Reported 2000 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 0.52 Pain Relevance 1.64

transport (HTR3A) plasma membrane (HTR3A) transmembrane transport (HTR3A)

Anatomy Link Frequency neuronal 1 cingulate cortex 1 HTR3A (Homo sapiens)

Pain Link Frequency Relevance Heat Neurotransmitter 4 100.00 Serotonin 3 99.22 Nucleus accumbens 1 97.28 substance P 3 96.72 amygdala 1 96.52 gABA 8 96.40 Hippocampus 3 96.12 Dorsal horn 1 93.60 Peripheral nervous system 1 92.72 agonist 5 77.84

Disease Link Frequency Relevance Heat Vomiting 6 92.72 Diarrhoea 3 91.84 Neuroblastoma 2 82.08 Pain 3 53.60 Anxiety Disorder 2 51.12 Functional Bowel Disorder 1 25.00 Sleep Disorders 1 25.00 Post-operative Nausea 1 25.00 Nociception 1 25.00 Rheumatic Diseases 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our results indicate that metformin induces 5-HT3 receptor-independent release of 5-HT from human duodenal mucosa via neuronal and non-neuronal mechanisms.

Localization (release) of 5-HT3 in neuronal

1) Confidence 0.78 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10651152 Disease Relevance 0.08 Pain Relevance 0.40

Effects of metformin on intestinal 5-hydroxytryptamine (5-HT) release and on 5-HT3 receptors.

Localization (release) of 5-HT3

2) Confidence 0.73 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 10651152 Disease Relevance 0.28 Pain Relevance 0.30

In the CNS, the 5-HT3 receptor has been localized in the area postrema, nucleus tractus solitarii, nucleus vaudatus, nucleus accumbens, amygdala, hippocampus, entorhinal, frontal, cingulate cortex, and in the dorsal horn ganglia.

Localization (localized) of 5-HT3 in cingulate cortex associated with nucleus accumbens, dorsal horn, hippocampus and amygdala

3) Confidence 0.73 Published 2004 Journal Scand. J. Rheumatol. Suppl. Section Abstract Doc Link 15515404 Disease Relevance 0.16 Pain Relevance 0.54

Serotonin 5-hydroxytryptamine type 3 receptors (5HT3R) are Ca2+-permeant, non-selective cation channels that have been localized to presynaptic terminals and demonstrated to modulate neurotransmitter release.

Localization (release) of 5HT3R associated with neurotransmitter and serotonin

4) Confidence 0.13 Published 2004 Journal Neuroscience Section Abstract Doc Link 15541891 Disease Relevance 0 Pain Relevance 0.40

General Comments

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