INT86092

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.52
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (HTR3A) plasma membrane (HTR3A) transmembrane transport (HTR3A)
Anatomy Link Frequency
neuronal 1
cingulate cortex 1
HTR3A (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 4 100.00 Very High Very High Very High
Serotonin 3 99.22 Very High Very High Very High
Nucleus accumbens 1 97.28 Very High Very High Very High
substance P 3 96.72 Very High Very High Very High
amygdala 1 96.52 Very High Very High Very High
gABA 8 96.40 Very High Very High Very High
Hippocampus 3 96.12 Very High Very High Very High
Dorsal horn 1 93.60 High High
Peripheral nervous system 1 92.72 High High
agonist 5 77.84 Quite High
Disease Link Frequency Relevance Heat
Vomiting 6 92.72 High High
Diarrhoea 3 91.84 High High
Neuroblastoma 2 82.08 Quite High
Pain 3 53.60 Quite High
Anxiety Disorder 2 51.12 Quite High
Functional Bowel Disorder 1 25.00 Low Low
Sleep Disorders 1 25.00 Low Low
Post-operative Nausea 1 25.00 Low Low
Nociception 1 25.00 Low Low
Rheumatic Diseases 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results indicate that metformin induces 5-HT3 receptor-independent release of 5-HT from human duodenal mucosa via neuronal and non-neuronal mechanisms.
Localization (release) of 5-HT3 in neuronal
1) Confidence 0.78 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10651152 Disease Relevance 0.08 Pain Relevance 0.40
Effects of metformin on intestinal 5-hydroxytryptamine (5-HT) release and on 5-HT3 receptors.
Localization (release) of 5-HT3
2) Confidence 0.73 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 10651152 Disease Relevance 0.28 Pain Relevance 0.30
In the CNS, the 5-HT3 receptor has been localized in the area postrema, nucleus tractus solitarii, nucleus vaudatus, nucleus accumbens, amygdala, hippocampus, entorhinal, frontal, cingulate cortex, and in the dorsal horn ganglia.
Localization (localized) of 5-HT3 in cingulate cortex associated with nucleus accumbens, dorsal horn, hippocampus and amygdala
3) Confidence 0.73 Published 2004 Journal Scand. J. Rheumatol. Suppl. Section Abstract Doc Link 15515404 Disease Relevance 0.16 Pain Relevance 0.54
Serotonin 5-hydroxytryptamine type 3 receptors (5HT3R) are Ca2+-permeant, non-selective cation channels that have been localized to presynaptic terminals and demonstrated to modulate neurotransmitter release.
Localization (release) of 5HT3R associated with neurotransmitter and serotonin
4) Confidence 0.13 Published 2004 Journal Neuroscience Section Abstract Doc Link 15541891 Disease Relevance 0 Pain Relevance 0.40

General Comments

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