INT86098

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Context Info
Confidence 0.44
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.07
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Thpo) extracellular space (Thpo) extracellular region (Thpo)
Anatomy Link Frequency
brain 2
platelet 1
BFU-E 1
Thpo (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 1 91.68 High High
headache 2 89.72 High High
Hippocampus 27 84.16 Quite High
Angina 1 80.44 Quite High
agonist 1 77.36 Quite High
Thalamus 15 71.76 Quite High
medulla 24 63.28 Quite High
Central nervous system 42 62.00 Quite High
Spinal cord 24 58.40 Quite High
cerebral cortex 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 10 100.00 Very High Very High Very High
Headache 1 89.72 High High
Myelodysplastic Syndromes 9 88.48 High High
Thrombosis 1 87.56 High High
Congenital Anomalies 25 84.44 Quite High
Myeloproliferative Disorder 1 82.40 Quite High
Thrombosis Related Under Development 2 81.68 Quite High
Sepsis 1 80.88 Quite High
Cv General 3 Under Development 4 80.44 Quite High
Disease 1 66.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further elucidate the role of the Thpo/Mpl system in the brain, we analysed herein the expression pattern of the Mpl protein in the murine brain by immunohistochemistry.
Regulation (role) of Thpo in brain
1) Confidence 0.44 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.08 Pain Relevance 0.03
RT-PCR analysis indicated a developmental up-regulation of Thpo mRNA.
Regulation (regulation) of Thpo mRNA
2) Confidence 0.44 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.03
This may be important for future dissection of the regulation and function of the Thpo/Mpl system in the brain.
Regulation (regulation) of Thpo in brain
3) Confidence 0.26 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.14
We then studied the effects of acute smoking and smoking cessation on TPO levels and platelet activation indices.
Regulation (effects) of TPO in platelet associated with nicotine addiction
4) Confidence 0.26 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 20006331 Disease Relevance 0.85 Pain Relevance 0.12
None of the patients had spontaneous BFU-E or altered levels of serum erythropoietin and thrombopoietin.
Regulation (altered) of thrombopoietin in BFU-E
5) Confidence 0.15 Published 2000 Journal Br. J. Haematol. Section Abstract Doc Link 10651728 Disease Relevance 1.13 Pain Relevance 0.14

General Comments

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