INT861

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Context Info
Confidence 0.37
First Reported 1979
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 3.84
Pain Relevance 3.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger1) signal transducer activity (Ptger1)
Anatomy Link Frequency
PGE1 2
blood 1
hypothalamus 1
Ptger1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 6 100.00 Very High Very High Very High
Enkephalin 5 100.00 Very High Very High Very High
narcan 4 100.00 Very High Very High Very High
analgesia 2 100.00 Very High Very High Very High
Antinociceptive 8 98.84 Very High Very High Very High
tolerance 3 98.52 Very High Very High Very High
ischemia 2 97.52 Very High Very High Very High
Migraine 3 96.88 Very High Very High Very High
Serotonin 3 96.68 Very High Very High Very High
Angina 1 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Coagulation Disorder 1 99.36 Very High Very High Very High
Impaired Glucose Tolerance 1 98.52 Very High Very High Very High
Coronary Artery Disease 5 97.96 Very High Very High Very High
Headache 4 96.88 Very High Very High Very High
Pressure And Volume Under Development 5 96.12 Very High Very High Very High
Stable Angina Pectoris 1 95.60 Very High Very High Very High
Suicidal Behaviour 1 93.20 High High
Nociception 3 91.56 High High
Syncope 1 90.80 High High
Fatigue 1 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several PG synthesis inhibitors were shown to inhibit morphine analgesia and PGE1 was shown to potentiate the antinociceptive effect of morphine.
Negative_regulation (inhibit) of PGE1 associated with antinociceptive, analgesia and morphine
1) Confidence 0.37 Published 1979 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 106425 Disease Relevance 0.16 Pain Relevance 0.89
This effect of PGE1, was maximal when it was injected together with carrageenan, there being a reduction in the action of PGE1 if carrageenan injection was delayed after PGE1 injection.
Negative_regulation (reduction) of PGE1
2) Confidence 0.36 Published 1980 Journal Prostaglandins Section Abstract Doc Link 7384537 Disease Relevance 0.46 Pain Relevance 0.21
From this observation we can suppose that the decreased affinity of PGE1-receptors, causing decreased cAMP levels, may be involved in pathogenesis of migraine.
Negative_regulation (decreased) of PGE1 in PGE1 associated with migraine
3) Confidence 0.29 Published 1993 Journal Funct. Neurol. Section Abstract Doc Link 8150318 Disease Relevance 0.26 Pain Relevance 0.26
Inhibition of PGE1 induced intestinal secretion by the synthetic enkephalin analogue FK 33-824.
Negative_regulation (Inhibition) of PGE1 associated with enkephalin
4) Confidence 0.14 Published 1979 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 503254 Disease Relevance 0 Pain Relevance 0.77
From a pathophysiologic point of view PMTS may be considered a deficiency of PGE1 activity in the hypothalamus and the temporal cortical areas.
Negative_regulation (deficiency) of PGE1 in hypothalamus
5) Confidence 0.04 Published 1980 Journal Med. Hypotheses Section Abstract Doc Link 7001193 Disease Relevance 0.57 Pain Relevance 0.12
A significant increase in the levels of thromboxane and PGF2 alpha was found with relative prostacyclin and PGE1 deficiency during graded exercise at the moment of transient myocardial ischemia; the imbalance significantly increased as exercise tolerance decreased.
Negative_regulation (deficiency) of PGE1 associated with coronary artery disease, ischemia and tolerance
6) Confidence 0.01 Published 1993 Journal Kardiologiia Section Abstract Doc Link 8377329 Disease Relevance 0.36 Pain Relevance 0.24
The inhibitory effect of the 0.1 microgram.kg-1.min-1 PGE1 on BP was similar to that of lidocaine 1 mg.kg-1 iv.
Negative_regulation (effect) of PGE1 in PGE1
7) Confidence 0.01 Published 1996 Journal Can J Anaesth Section Body Doc Link 8807172 Disease Relevance 0 Pain Relevance 0
Deficiency of the prostaglandin PGE1 may also be involved in PMT-C.
Negative_regulation (Deficiency) of PGE1
8) Confidence 0.00 Published 1983 Journal J Reprod Med Section Abstract Doc Link 6684167 Disease Relevance 1.33 Pain Relevance 0.43
Serum prostaglandin concentrations, which reflect synthesis by platelets during the clotting of blood, revealed significant decreases in PGE1, PGE2, and PGF2 alpha and thromboxane B2 within two to four hours after drug administration in all subjects with or without ASA idiosyncrasy.
Negative_regulation (decreases) of PGE1 in blood associated with aspirin and coagulation disorder
9) Confidence 0.00 Published 1981 Journal Chest Section Abstract Doc Link 7307588 Disease Relevance 0.70 Pain Relevance 0.57

General Comments

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