INT86111

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 38
Total Number 42
Disease Relevance 33.81
Pain Relevance 5.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
neutrophils 3
cochlea 2
lymph nodes 2
corpus 2
epithelium 2
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 33 99.98 Very High Very High Very High
cytokine 101 99.96 Very High Very High Very High
endometriosis 231 99.92 Very High Very High Very High
cINOD 14 99.62 Very High Very High Very High
Inflammation 281 99.16 Very High Very High Very High
Morphine 9 98.92 Very High Very High Very High
Arthritis 75 98.86 Very High Very High Very High
pulpitis 2 98.56 Very High Very High Very High
Kinase C 7 93.44 High High
metalloproteinase 59 92.40 High High
Disease Link Frequency Relevance Heat
Cancer 1157 100.00 Very High Very High Very High
Endometriosis 329 100.00 Very High Very High Very High
Hypoxia 283 100.00 Very High Very High Very High
Atherosclerosis 77 100.00 Very High Very High Very High
Aggression 3 100.00 Very High Very High Very High
Coronary Artery Disease 163 99.98 Very High Very High Very High
Disease 331 99.84 Very High Very High Very High
INFLAMMATION 301 99.50 Very High Very High Very High
Retina Disease 37 99.46 Very High Very High Very High
Metastasis 319 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transfection of HUVECs with a human VEGF promoter-luciferase construct showed that hypoxia-induced transcriptional activation of VEGF was markedly inhibited by morphine sulfate (P<0.05).
Positive_regulation (induced) of Positive_regulation (activation) of VEGF associated with hypoxia and morphine
1) Confidence 0.69 Published 2001 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 11735263 Disease Relevance 0.75 Pain Relevance 1.07
It is unclear, however, whether acute myocardial ischemia leads to a detectable elevation of VEGF-A serum concentrations.
Spec (whether) Positive_regulation (leads) of Spec (whether) Positive_regulation (elevation) of VEGF associated with coronary artery disease and ischemia
2) Confidence 0.67 Published 2000 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 10652191 Disease Relevance 0.96 Pain Relevance 0.30
Tumor necrosis factor alpha (TNF-alpha) was required for this induction of VEGF.
Positive_regulation (required) of Positive_regulation (induction) of VEGF associated with necrosis and cancer
3) Confidence 0.50 Published 2002 Journal J. Orthop. Res. Section Abstract Doc Link 12038611 Disease Relevance 0.92 Pain Relevance 0.26
Despite these data, the clinical applicability of VEGF measurement remains to be evaluated in larger prospective studies.



Positive_regulation (evaluated) of Positive_regulation (measurement) of VEGF
4) Confidence 0.49 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.55 Pain Relevance 0
With respect to pathogenesis, among others, upregulation of the glykopeptide VEGF-D, a vascular endothelial growth factor, seems to be responsible for the endothelial cell proliferation [4].
Positive_regulation (responsible) of Positive_regulation (upregulation) of vascular endothelial growth factor in endothelial cell
5) Confidence 0.49 Published 2008 Journal Head Face Med Section Body Doc Link PMC2533304 Disease Relevance 1.61 Pain Relevance 0.06
Our contribution to the proposed model is that the induction of VEGF in the periphery could require preconditioning of the monocytes which is performed during the chronic myocardial ischemic condition observed in the CAD SA group.
Positive_regulation (require) of Positive_regulation (induction) of VEGF in monocytes associated with coronary artery disease
6) Confidence 0.48 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 0.93 Pain Relevance 0.17
RD patients did not show any elevated levels of VEGF.
Neg (not) Positive_regulation (levels) of Positive_regulation (elevated) of VEGF associated with retina disease
7) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780733 Disease Relevance 1.03 Pain Relevance 0
RD patients did not show any elevated levels of VEGF.
Positive_regulation (elevated) of Neg (not) Positive_regulation (levels) of VEGF associated with retina disease
8) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780733 Disease Relevance 1.03 Pain Relevance 0
MAPK signaling is required for LPS-induced VEGF in pulp stem cells.
Positive_regulation (required) of Positive_regulation (induced) of VEGF in stem cells
9) Confidence 0.43 Published 2010 Journal J. Dent. Res. Section Title Doc Link 20110511 Disease Relevance 0.10 Pain Relevance 0.19
Previously we have shown that VEGF stimulation of HIMECs leads to a marked phosphorylation and activation of all three MAPK family members (p44/42 MAPK, stress-activated protein kinase (SAPK)/JNK and p38 MAPK).25 To investigate whether MAPK pathways play a role in VEGF induction of COX-2, HIMECs were pretreated with specific MAPK inhibitors then activated with VEGF.
Spec (whether) Positive_regulation (role) of Positive_regulation (induction) of VEGF associated with stress
10) Confidence 0.42 Published 2008 Journal Gut Section Body Doc Link PMC2582343 Disease Relevance 0.10 Pain Relevance 0.03
The high level of serum VEGF and bFGF reported in other stages of atherosclerosis should be accredited to other potential sites of production like the atherosclerotic lesion itself.
Positive_regulation (accredited) of Positive_regulation (level) of serum VEGF associated with atherosclerosis
11) Confidence 0.42 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.25 Pain Relevance 0.26
For tumors to attain a size beyond a few millimeters requires a process known as angiogenesis.25,26 Angiogenesis is a physiological process that depends on a well orchestrated balance of angiogenic factors and inhibitors that control the growth of microvessel sprouts via migration and proliferation of endothelial cells.27 When dysregulation of this process occurs, it may provide a suitable milieu for the initiation and maintenance of certain chronic disease states such psoriasis,28 ocular neovascularization29 and atherosclerosis.30 In addition, pathological angiogenesis has been shown to be a hallmark of certain tumor types such as GBM, colorectal carcinoma, breast and renal cell carcinomas.31 Tumor-associated neo-vascularization differs from physiological angiogenesis, characterized by a substantial increase in the proliferation activity of endothelial cells that are structurally “leaky”.32 Tipping the scales in favor of a proangiogenic state requires upregulation of factors such as VEGF-A, platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF2).33–35 Additional pathways implicated in tumor angiogenesis are angiopoietin and Notch.36 Enzymes such as metalloproteinase and serine proteinase have been shown to be involved in the induction and suppression of angiogenesis by degrading the extracellular matrix.37 These have all been identified as possible substrates for therapeutic intervention.
Positive_regulation (requires) of Positive_regulation (upregulation) of VEGF in platelet associated with psoriasis, renal cancer, colon cancer, increased venous pressure under development, cancer, glioblastoma, metalloproteinase, pathologic neovascularization and chronic disease
12) Confidence 0.41 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895775 Disease Relevance 1.48 Pain Relevance 0.09
There are various reasons for the ineffectiveness of imatinib monotherapy in ovarian cancer: downregulation of c-kit and PDGFR may lead to induction of VEGF, inhibition of a single tyrosine kinase might be insufficient to impact downstream signaling cascades, and the molecular targets of imatinib might not be relevant in the occurrence of ovarian cancer in comparison with gastrointestinal stromal tumor or chronic myeloid leukemia where a single specific mutation or a translocation, respectively, can be responsible for the genesis of these two cancers [62].
Spec (may) Positive_regulation (lead) of Positive_regulation (induction) of VEGF associated with leukemia, cancer, ovarian cancer and gastrointestinal stromal tumor
13) Confidence 0.40 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 1.08 Pain Relevance 0
Inflammatory tissue is often hypoxic, and hypoxia can induce angiogenesis through upregulation of factors such as VEGF.
Positive_regulation (induce) of Positive_regulation (upregulation) of VEGF associated with inflammation and hypoxia
14) Confidence 0.39 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128891 Disease Relevance 1.57 Pain Relevance 0.43
VEGF has a hypoxic response element in its promoter and is one of several genes that are upregulated in a low oxygen microenvironment to elicit a vascular phenotype.
Positive_regulation (upregulated) of Positive_regulation (upregulated) of VEGF associated with hypoxia
15) Confidence 0.37 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246178 Disease Relevance 0.91 Pain Relevance 0.04
The question of whether the increased VEGF level detected were due to a residual in-situ production or an increase in permeability of the damaged tissue was not answered with this study.
Positive_regulation (due) of Positive_regulation (increased) of VEGF
16) Confidence 0.35 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2938272 Disease Relevance 0.23 Pain Relevance 0
For mechanisms of VEGF induction via EP2 or EP4 activation, recent studies have indicated involvement of cAMP- and PKA-dependent mechanisms via SP-1 transcription factor binding sites on the VEGF promoter [12,24,25].
Positive_regulation (activation) of Positive_regulation (induction) of VEGF
17) Confidence 0.29 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.17 Pain Relevance 0.06
Because HIF-1alpha is the major trigger for hypoxia-induced activation of the VEGF and Flt-1 genes, this could explain how NSAIDs inhibit hypoxia-induced angiogenesis.
Positive_regulation (hypoxia-induced) of Positive_regulation (activation) of VEGF associated with hypoxia and cinod
18) Confidence 0.28 Published 2002 Journal FASEB J. Section Abstract Doc Link 11772947 Disease Relevance 0.98 Pain Relevance 0.62
VEGF upregulation in the cochlea is induced not only by intense noise exposure [20,30] but also by moderate noise exposure [21].
Positive_regulation (induced) of Positive_regulation (upregulation) of VEGF in cochlea
19) Confidence 0.27 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.43 Pain Relevance 0.11
These hypoxic conditions may be a driving force for VEGF upregulation which may cause inhibition of sema3A activity through competitive receptor binding.
Positive_regulation (force) of Positive_regulation (upregulation) of VEGF associated with hypoxia
20) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.35 Pain Relevance 0

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