INT86119

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Context Info
Confidence 0.45
First Reported 2000
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 13
Total Number 17
Disease Relevance 14.08
Pain Relevance 5.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Cftr) enzyme binding (Cftr) molecular_function (Cftr)
protein complex (Cftr) transmembrane transport (Cftr) cytoplasm (Cftr)
Anatomy Link Frequency
photoreceptor 1
pancreas 1
T84 1
epithelial cells 1
ventral 1
Cftr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 228 100.00 Very High Very High Very High
Chronic pancreatitis 34 99.68 Very High Very High Very High
qutenza 4 99.28 Very High Very High Very High
Serotonin 1 99.12 Very High Very High Very High
Prostatitis 272 98.88 Very High Very High Very High
cytokine 56 98.00 Very High Very High Very High
fluoxetine 2 97.92 Very High Very High Very High
Inflammation 126 97.60 Very High Very High Very High
Pain 9 73.12 Quite High
alcohol 2 69.80 Quite High
Disease Link Frequency Relevance Heat
Cystic Fibrosis 224 100.00 Very High Very High Very High
Pancreatitis 144 99.68 Very High Very High Very High
Bacterial Infection 92 99.62 Very High Very High Very High
Prostatitis 272 98.88 Very High Very High Very High
Congenital Anomalies 6 98.64 Very High Very High Very High
Malignant Neoplastic Disease 20 98.44 Very High Very High Very High
INFLAMMATION 134 97.60 Very High Very High Very High
Appetite Loss 4 96.92 Very High Very High Very High
Disease 42 96.88 Very High Very High Very High
Infection 22 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
are also found in prostatitis, with or without bacterial infection, they may also up regulate CFTR in the prostate, thereby enhancing HCO3?
Spec (may) Regulation (regulate) of CFTR associated with prostatitis and bacterial infection
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 1.28 Pain Relevance 0.54
[Frequency of CFTR gene mutations in idiopathic pancreatitis].
Regulation ([Frequency) of CFTR associated with pancreatitis
2) Confidence 0.45 Published 2003 Journal Gastroenterol. Clin. Biol. Section Title Doc Link 12759680 Disease Relevance 0.29 Pain Relevance 0.14
The more recently recognized entity of CFTR-related pancreatitis suggests that the pancreas is also particularly sensitive to CFTR dysfunction.
Regulation (sensitive) of CFTR in pancreas associated with pancreatitis
3) Confidence 0.45 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 0.55 Pain Relevance 0.11
At present there is no evidence that CFTR mutations are directly responsible for oncogenicity.
Regulation (responsible) of CFTR
4) Confidence 0.45 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 1.59 Pain Relevance 0.25
Topical carbachol, capsaicin, forskolin or CFTR(inh)-172 had no effect on basal Isc.CFTR(inh)-172 did not reduce the acid-increased Isc.
Neg (no) Regulation (effect) of CFTR associated with qutenza
5) Confidence 0.42 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18953095 Disease Relevance 0.06 Pain Relevance 0.28
Genes regulating trypsinogen activation/inactivation and cystic fibrosis transmembrane conductance regulator (CFTR) function have received particular attention.
Regulation (regulating) of cystic fibrosis transmembrane conductance regulator associated with fibrosis and cystic fibrosis
6) Confidence 0.39 Published 2007 Journal Gastroenterology Section Abstract Doc Link 17466744 Disease Relevance 1.78 Pain Relevance 0.97
To further confirm whether CFTR was involved in the NAR induced chloride secretion, we also performed whole-cell patch-clamp experiment on T84 cells, with several lines of evidence suggesting that the NAR-activated Cl?
Spec (whether) Regulation (involved) of CFTR in T84
7) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553183 Disease Relevance 0.05 Pain Relevance 0
As shown in Figure 3B and 3C, mRNA and protein expression of CFTR and CAII were significantly up-regulated upon stimulation of E.coli-LPS, respectively.
Regulation (regulated) of CFTR
8) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.69 Pain Relevance 0.43
have potent effect on up-regulation of CFTR in epithelial cells [36], [37].
Regulation (regulation) of CFTR in epithelial cells
9) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 1.10 Pain Relevance 0.47
Specific mutations in CFTR, the gene responsible for cystic fibrosis, have not been reported previously in patients with AWP.
Regulation (responsible) of CFTR associated with fibrosis and cystic fibrosis
10) Confidence 0.27 Published 2005 Journal Arch Dermatol Section Abstract Doc Link 15897385 Disease Relevance 0.42 Pain Relevance 0.13
Additionally, western blot experiments showed that there was no difference in CFTR expression between the control (data not shown), loperamide and NAR-treated loperamide-administered group, implying the direct modulation of naringenin on the CFTR function rather than expression.
Regulation (modulation) of CFTR
11) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2553183 Disease Relevance 0.69 Pain Relevance 0
Extended Cystic Fibrosis Transmembrane Receptor (CFTR) mutation analysis showed that the patient was positive for the L997F mutation in addition to the ?
Regulation (Extended) of CFTR associated with fibrosis and cystic fibrosis
12) Confidence 0.21 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2435544 Disease Relevance 0.93 Pain Relevance 0.40
Immunohistochemistry revealed that CFTR immunoreactivity was detected in the apical surface of the epithelial cells of the rat ventral prostate (Figure 1A).
Regulation (immunoreactivity) of CFTR in ventral
13) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.36 Pain Relevance 0.18
Extended Cystic Fibrosis Transmembrane Receptor (CFTR) mutation analysis showed that the patient was positive for the L997F mutation in addition to the ?
Regulation (Extended) of Cystic Fibrosis Transmembrane Receptor associated with fibrosis and cystic fibrosis
14) Confidence 0.18 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2435544 Disease Relevance 0.93 Pain Relevance 0.40
Genes regulating trypsinogen activation/inactivation and cystic fibrosis transmembrane conductance regulator (CFTR) function have received particular attention.
Regulation (regulating) of CFTR associated with fibrosis and cystic fibrosis
15) Confidence 0.17 Published 2007 Journal Gastroenterology Section Abstract Doc Link 17466744 Disease Relevance 1.78 Pain Relevance 0.97
Based upon previous reports of its efficacy as an inhibitor of a volume regulated chloride channel (VRAC), a calcium-dependent chloride channel, and the cystic fibrosis transmembrane conductance regulator (CFTR), we investigated whether the serotonin reuptake inhibitor, fluoxetine hydrochloride, could act as a specific blocker for ICl(Ca) in salamander rod photoreceptor terminals, without affecting other aspects of rod physiology.
Regulation (regulated) of CFTR in photoreceptor associated with fibrosis, cystic fibrosis, serotonin and fluoxetine
16) Confidence 0.07 Published 2005 Journal Mol. Vis. Section Abstract Doc Link 16402020 Disease Relevance 0.10 Pain Relevance 0.27
However, neither the R117H nor the N21L mutation in the cationic trypsinogen were found in the HP family with the L327R alteration in CFTR.
Regulation (alteration) of CFTR associated with pancreatitis
17) Confidence 0.06 Published 2000 Journal Pflugers Arch. Section Abstract Doc Link 10653140 Disease Relevance 1.46 Pain Relevance 0.21

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