INT86160

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Context Info
Confidence 0.39
First Reported 2000
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.53
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pvalb)
Anatomy Link Frequency
inhibitory interneurons 1
brain 1
Pvalb (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 6 100.00 Very High Very High Very High
mu opioid receptor 7 95.08 Very High Very High Very High
GABAergic 22 88.88 High High
Opioid 2 81.84 Quite High
Hippocampus 13 70.88 Quite High
Pyramidal cell 14 65.44 Quite High
Enkephalin 2 53.84 Quite High
cytokine 9 28.80 Quite Low
Inflammation 7 28.44 Quite Low
imagery 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 36 97.56 Very High Very High Very High
Aging 23 92.64 High High
Frailty 2 36.76 Quite Low
Hypertension 2 36.24 Quite Low
Apnoea 1 35.68 Quite Low
Obesity 1 34.68 Quite Low
Diabetes Mellitus 2 34.32 Quite Low
Increased Venous Pressure Under Development 2 33.92 Quite Low
INFLAMMATION 7 28.44 Quite Low
Targeted Disruption 6 18.24 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The influence of chronic maternal morphine on the parvalbumin immunoreactive patterns in developing mouse brain was studied.
Regulation (influence) of parvalbumin in brain associated with morphine
1) Confidence 0.39 Published 2000 Journal Synapse Section Abstract Doc Link 10657036 Disease Relevance 0 Pain Relevance 0.33
The number of PARV-labeled cells was not affected by estrous cycle phase or estrogen levels.
Neg (not) Regulation (affected) of PARV
2) Confidence 0.26 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19505458 Disease Relevance 0 Pain Relevance 0.48
Further, because PV-interneurons are also selectively affected by commonly used anesthetic agents and drugs, our findings imply that IL-6 levels may predict adverse CNS effects in older patients exposed to these compounds through specific derangements in inhibitory interneurons, and that therapies directed at lowering IL-6 may have cognitive benefits clinically.



Regulation (affected) of PV-interneurons in inhibitory interneurons associated with cognitive disorder
3) Confidence 0.11 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2678193 Disease Relevance 0.53 Pain Relevance 0.15
In contrast to Pv-cre mice, control wildtype mice injected with AAV-LS1L-GFP showed little GFP signal (Fig. 2a).
Regulation (control) of Pv-cre
4) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289876 Disease Relevance 0 Pain Relevance 0.03

General Comments

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