INT86179

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Context Info
Confidence 0.35
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.66
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, IL6) extracellular region (TNF, IL6) signal transduction (TNF)
aging (IL6) plasma membrane (TNF) intracellular (TNF)
Anatomy Link Frequency
leukocyte 2
fibroblasts 2
TNF (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 43 100.00 Very High Very High Very High
Inflammation 44 99.66 Very High Very High Very High
Adalimumab 102 99.64 Very High Very High Very High
substance P 7 99.30 Very High Very High Very High
antagonist 4 95.40 Very High Very High Very High
qutenza 6 95.36 Very High Very High Very High
psoriasis 53 90.48 High High
methotrexate 19 84.68 Quite High
Infliximab 17 82.72 Quite High
rheumatoid arthritis 21 80.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 55 99.66 Very High Very High Very High
Adhesions 1 94.32 High High
Periodontal Disease 8 92.36 High High
Psoriasis 61 90.48 High High
Rheumatoid Arthritis 21 80.40 Quite High
Periodontitis 5 75.20 Quite High
Apoptosis 4 74.88 Quite High
Mouth Disease 49 66.72 Quite High
Disease 26 64.56 Quite High
Necrosis 6 59.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: A reduction of TNF-alpha-induced IL-6 release after treatment with hyaluronic acid and chondroitin sulfate was observed, indicating the anti-inflammatory action of the preparation.
TNF-alpha Positive_regulation (induced) of Localization (release) of IL-6
1) Confidence 0.35 Published 2009 Journal Aktuelle Urol Section Body Doc Link 19296424 Disease Relevance 0 Pain Relevance 0
Furthermore, IL-1beta and tumor necrosis factor-alpha alone induced significant release of MCP-1, IL-6 and SCF but in combination with IL-4 or IL-13 it induced greater secretion of MCP-1, IL-6 and SCF.
tumor necrosis factor-alpha Positive_regulation (induced) of Localization (release) of IL-6
2) Confidence 0.27 Published 2006 Journal J. Urol. Section Body Doc Link 16407046 Disease Relevance 0.12 Pain Relevance 0
They are both produced by the same variety of cells, with macrophages likely to be the most important source of these mediators in the early stages of gingival inflammation [70, 71], while TNF- a acts synergistically with IL-1b to stimulate gingival fibroblasts to enhance IL-6 secretion [72].
TNF Positive_regulation (enhance) of Localization (secretion) of IL-6 in fibroblasts associated with inflammation
3) Confidence 0.20 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2874215 Disease Relevance 0.48 Pain Relevance 0.17
Through this mechanism, adalimumab inhibits several TNF-alpha-induced events, ie, the release of serum cytokines (IL-6), acute phase reactants of inflammation, matrix metalloproteases and other markers of cartilage and synovium turnover, and the expression of adhesion molecules responsible for leukocyte migration (Mease 2005).
TNF Positive_regulation (induced) of Localization (release) of IL-6 in leukocyte associated with inflammation, adalimumab, adhesions and cytokine
4) Confidence 0.03 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721299 Disease Relevance 0.75 Pain Relevance 0.74
In addition to the direct stimulation of inflammatory cytokines, SP (0.5 microM), in combination with TNFalpha (25 units/ml), synergistically stimulated IL-6 release.
TNFalpha Positive_regulation (stimulated) of Localization (release) of IL-6 associated with inflammation, substance p and cytokine
5) Confidence 0.01 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657523 Disease Relevance 0.31 Pain Relevance 1.26

General Comments

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