INT86180

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Context Info
Confidence 0.06
First Reported 1999
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.01
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPA1, IL6) extracellular region (SFTPA1, IL6) aging (IL6)
SFTPA1 (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 49 100.00 Very High Very High Very High
cytokine 37 100.00 Very High Very High Very High
substance P 28 100.00 Very High Very High Very High
Nerve growth factor 16 98.72 Very High Very High Very High
Pain 16 97.24 Very High Very High Very High
Peripheral nervous system 1 96.92 Very High Very High Very High
antagonist 3 96.88 Very High Very High Very High
qutenza 6 95.36 Very High Very High Very High
Neurotransmitter 2 95.12 Very High Very High Very High
Neuropeptide 6 90.36 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 49 100.00 Very High Very High Very High
Stress 34 99.12 Very High Very High Very High
Anxiety Disorder 2 97.60 Very High Very High Very High
Pain 17 97.24 Very High Very High Very High
Endometriosis 224 80.20 Quite High
Neurogenic Inflammation 1 73.44 Quite High
Lymphocytosis 1 67.76 Quite High
Disease 24 18.80 Low Low
Reprotox - General 3 21 5.00 Very Low Very Low Very Low
Adhesions 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to the direct stimulation of inflammatory cytokines, SP (0.5 microM), in combination with TNFalpha (25 units/ml), synergistically stimulated IL-6 release.
SP Positive_regulation (stimulated) of Localization (release) of IL-6 associated with inflammation, substance p and cytokine
1) Confidence 0.06 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657523 Disease Relevance 0.32 Pain Relevance 1.27
Additionally, SP is a potent pro-inflammatory mediator, as it induces the production and release of cytokines such as IL-1, IL-6, and TNF-?
SP Positive_regulation (induces) of Localization (release) of IL-6 associated with inflammation, cytokine and substance p
2) Confidence 0.00 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 1.69 Pain Relevance 1.58

General Comments

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