INT86184

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Context Info
Confidence 0.34
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 14
Disease Relevance 20.45
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Acsl1) endoplasmic reticulum (Acsl1) plasma membrane (Acsl1)
peroxisome (Acsl1) ligase activity (Acsl1) lipid metabolic process (Acsl1)
Anatomy Link Frequency
extremity 2
AcS 1
puncture 1
Heart 1
Acsl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 111 100.00 Very High Very High Very High
Pain 11 99.12 Very High Very High Very High
antidepressant 14 98.66 Very High Very High Very High
ischemia 68 97.40 Very High Very High Very High
abdominal pain 4 95.24 Very High Very High Very High
Dorsal horn 1 92.56 High High
amygdala 10 91.00 High High
Spinal cord 5 89.12 High High
cva 10 87.84 High High
Inflammation 19 85.04 High High
Disease Link Frequency Relevance Heat
Compartment Syndromes 168 100.00 Very High Very High Very High
Carotid Stenosis 125 100.00 Very High Very High Very High
Depression 123 100.00 Very High Very High Very High
Acute Coronary Syndrome 50 100.00 Very High Very High Very High
Peripheral Arterial Disease 110 99.84 Very High Very High Very High
Carcinoma 2 99.76 Very High Very High Very High
Pancreatitis 160 99.32 Very High Very High Very High
Pain 8 99.12 Very High Very High Very High
Myocardial Infarction 49 98.92 Very High Very High Very High
Atherosclerosis 31 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The incidence and number of carcinomas, including ACs, SqCs and ASqCs were decreased in rats given ABPC plus piroxicam or ABPC plus ougon.
Negative_regulation (decreased) of ACs associated with carcinoma
1) Confidence 0.34 Published 2000 Journal Carcinogenesis Section Abstract Doc Link 10657965 Disease Relevance 0.85 Pain Relevance 0.17
In this study, we attempted to investigate prevalence of ACAS in patients who underwent bypass surgery due to chronic lower extremity ischemia and identify predictive factors of ACAS.


Spec (investigate) Negative_regulation (prevalence) of ACAS in extremity associated with ischemia and carotid stenosis
2) Confidence 0.29 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908785 Disease Relevance 2.03 Pain Relevance 0.09
Several previous studies reported that the prevalence of ACAS was relatively high in PAD patients and the authors recommended routine CDUS (11, 12).
Negative_regulation (prevalence) of ACAS associated with peripheral arterial disease and carotid stenosis
3) Confidence 0.29 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908785 Disease Relevance 2.39 Pain Relevance 0.03
In Korea, the prevalence of ACAS in PAD patients has not yet been reported.
Negative_regulation (prevalence) of ACAS associated with peripheral arterial disease and carotid stenosis
4) Confidence 0.29 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908785 Disease Relevance 2.11 Pain Relevance 0.08
There are no known data regarding the prevalence of ACAS in patients with PAD.
Negative_regulation (prevalence) of ACAS associated with peripheral arterial disease and carotid stenosis
5) Confidence 0.29 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908785 Disease Relevance 2.37 Pain Relevance 0.14
In summary, our results showed the prevalence of ACAS in Korean patients with chronic atherosclerotic lower extremity ischemia is as high as reported in Western countries.
Negative_regulation (prevalence) of ACAS in extremity associated with atherosclerosis, ischemia and carotid stenosis
6) Confidence 0.29 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908785 Disease Relevance 1.76 Pain Relevance 0.17
PAM (protein associated with Myc) is a potent inhibitor of adenylyl cyclases (ACs) which is primarily expressed in neurones.
Negative_regulation (inhibitor) of ACs
7) Confidence 0.27 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14756816 Disease Relevance 0.19 Pain Relevance 0.16
Amphetamine pre-exposure decreased GAD67 mRNA levels in the dLStr and the AcC and AcS, and this effect was reversed by amphetamine challenge.
Negative_regulation (decreased) of AcS in AcS
8) Confidence 0.25 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18312583 Disease Relevance 0.46 Pain Relevance 0.65
The main unanswered question for percutaneous puncture with placement of abdominal catheter is whether using this procedure is possible to achieve sufficient decompression and relief of ACS.
Negative_regulation (relief) of ACS in puncture associated with compartment syndromes
9) Confidence 0.16 Published 2010 Journal BMC Surg Section Body Doc Link PMC2913911 Disease Relevance 0.91 Pain Relevance 0
Several authors published relief of ACS after insertion of drain under radiological guidance [12,17-19].
Negative_regulation (relief) of ACS associated with compartment syndromes
10) Confidence 0.16 Published 2010 Journal BMC Surg Section Body Doc Link PMC2913911 Disease Relevance 1.71 Pain Relevance 0
However, the lack of a definition of ACS and methodological issues, make interpretation of these results and some other studies difficult.
Negative_regulation (definition) of ACS associated with compartment syndromes
11) Confidence 0.16 Published 2010 Journal BMC Surg Section Body Doc Link PMC2913911 Disease Relevance 1.92 Pain Relevance 0
Decompressive laparotomy for ACS associated with SAP has not been studied in large patients group [14].
Negative_regulation (Decompressive) of ACS associated with compartment syndromes and pancreatitis
12) Confidence 0.16 Published 2010 Journal BMC Surg Section Body Doc Link PMC2913911 Disease Relevance 0.96 Pain Relevance 0.10
Rather than being a transient reaction to having cardiac disease, depression in cardiac patients is often both chronic and recurrent.27,28 For example, the large Sertraline Antidepressant Heart Attack Randomized Trial (SADHART) trial27 found that, among ACS patients who entered the hospital with major depression, 94% of such patients had been depressed for over one month, 61% had been depressed for over six months and more than half had a prior major depressive episode.
Negative_regulation (depressed) of ACS in Heart associated with acute coronary syndrome, antidepressant, depression, heart disease and myocardial infarction
13) Confidence 0.03 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874336 Disease Relevance 1.96 Pain Relevance 0.41
Cardiac troponin T (cTnT) is useful for both purposes although cannot reliably rule out ACS until 12 hours after pain onset and does not fully define future risk.
Negative_regulation (rule) of ACS associated with pain and acute coronary syndrome
14) Confidence 0.02 Published 2009 Journal Adv Ther Section Abstract Doc Link 19475367 Disease Relevance 0.83 Pain Relevance 0.25

General Comments

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