INT86187

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2011
Negated 2
Speculated 9
Reported most in Body
Documents 199
Total Number 209
Disease Relevance 122.13
Pain Relevance 19.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AKT1) nucleoplasm (AKT1) transport (AKT1)
small molecule metabolic process (AKT1) enzyme binding (AKT1) carbohydrate metabolic process (AKT1)
Anatomy Link Frequency
fibroblasts 3
keratinocytes 2
MECs 2
AsPC-1 2
MDA-MB-231 2
AKT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 287 99.96 Very High Very High Very High
Kappa opioid receptor 8 99.92 Very High Very High Very High
Opioid 58 99.84 Very High Very High Very High
Cannabinoid receptor 2 99.82 Very High Very High Very High
diclofenac 41 99.78 Very High Very High Very High
aspirin 76 99.64 Very High Very High Very High
opioid receptor 6 99.62 Very High Very High Very High
Bile 24 99.60 Very High Very High Very High
cytokine 431 99.40 Very High Very High Very High
Pain 78 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 3271 100.00 Very High Very High Very High
Multiple Myeloma 202 100.00 Very High Very High Very High
Retinoblastoma 21 100.00 Very High Very High Very High
Hyperglycemia 142 99.98 Very High Very High Very High
Cancer 4969 99.88 Very High Very High Very High
Prostate Cancer 489 99.84 Very High Very High Very High
Bile Duct Neoplasms 78 99.84 Very High Very High Very High
Stomach Cancer 34 99.84 Very High Very High Very High
Breast Cancer 524 99.82 Very High Very High Very High
Renal Cancer 34 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MMP-2 promoter and enzyme activity were up-regulated in Akt kinase activity dependent manner.
Positive_regulation (up-regulated) of Akt kinase
1) Confidence 0.69 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 15546138 Disease Relevance 0.65 Pain Relevance 0.20
Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radioresistance.
Positive_regulation (activated) of AKT in bile duct associated with bile
2) Confidence 0.69 Published 2004 Journal Cancer Res. Section Title Doc Link 15150102 Disease Relevance 0.80 Pain Relevance 0.19
Next, to evaluate the role of AKT activation in the regulation of BDC cell radiosensitivity, clonogenic assays were performed using the phosphatidylinositol 3'-kinase inhibitor LY294002 with and without irradiation.
Positive_regulation (activation) of AKT associated with bile duct neoplasms
3) Confidence 0.69 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15150102 Disease Relevance 1.04 Pain Relevance 0.13
First, to examine whether activated AKT is expressed in BDCs, tumor specimens were obtained from 19 consecutive BDC cases.
Spec (whether) Positive_regulation (activated) of AKT associated with bile duct neoplasms and cancer
4) Confidence 0.69 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15150102 Disease Relevance 0.95 Pain Relevance 0.15
LY294002 inhibited AKT activation in BDC cells and, on irradiation, decreased clonogenic survival in a radiation dose-dependent manner.
Positive_regulation (activation) of AKT associated with bile duct neoplasms
5) Confidence 0.69 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15150102 Disease Relevance 0.92 Pain Relevance 0.09
The presence of SV40 has been shown to be associated with higher levels of vascular endothelial growth factor (VEGF) (Cacciotti, 2002), telomerase activity (Foddis, 2002), expression of the cell cycle inhibitor p21WAF1/CIP1 (Baldi, 2002), p53 inactivation (Carbone, 2003) and activation of the phosphatidylinositol 3-kinase/AKT signaling pathway (Cacciotti, 2001; Ramos-Nino, 2005).
Positive_regulation (activation) of AKT
6) Confidence 0.67 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 0.71 Pain Relevance 0
Aberrations leading to increased activation of the PI3K/AKT pathway are common in human cancers and are reviewed in [31].
Positive_regulation (activation) of AKT associated with cancer
7) Confidence 0.67 Published 2010 Journal Genome Biol Section Body Doc Link PMC2945784 Disease Relevance 0.73 Pain Relevance 0
When Western blot analysis of Akt protein was performed, we observed a moderate increase in Akt protein in the SiHa cells following valproic acid and butyrate treatment, rather than a decrease as in the HeLa cells (Fig. 5B).
Positive_regulation (increase) of Akt in HeLa
8) Confidence 0.64 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.32 Pain Relevance 0
Additionally, we report that overexpression of, and conditional activation of PKB attenuates the apoptotic effects of sulindac, but not for sulindac sulfide - the metabolic metabolite of sulindac.
Positive_regulation (activation) of PKB associated with apoptosis
9) Confidence 0.63 Published 2006 Journal Int. J. Oncol. Section Abstract Doc Link 16685448 Disease Relevance 0.32 Pain Relevance 0.07
through activation of Akt plays an important role in the UVB induction of COX-2 transcription [51].
Positive_regulation (activation) of Akt
10) Confidence 0.59 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.34 Pain Relevance 0.03
In the presence of a mutated-PTEN protein, activation of Akt generally occurs constitutively.
Positive_regulation (activation) of Akt
11) Confidence 0.59 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.23 Pain Relevance 0.04
Muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase in human skeletal muscle.
Positive_regulation (stimulation) of Akt in skeletal muscle associated with cytokine
12) Confidence 0.59 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Title Doc Link 10893341 Disease Relevance 0.58 Pain Relevance 0.19
In summary, the physiological stress associated with muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase, presumably leading to decreased insulin-mediated glucose uptake.
Positive_regulation (stimulation) of Akt in muscle associated with stress
13) Confidence 0.59 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 10893341 Disease Relevance 0.36 Pain Relevance 0.03
Due to the beneficial effect of sorafenib in HCC and strong activation of EGFR, ERK1 and AKT1, our patient received sorafenib.
Positive_regulation (activation) of AKT1 associated with hepatocellular cancer
14) Confidence 0.57 Published 2010 Journal Onkologie Section Abstract Doc Link 20502062 Disease Relevance 1.14 Pain Relevance 0.09
Recently, interactions between the PI3K/AKT and p53 signaling pathways have been described in which activation of the PI3K/AKT pathway through PTEN or PIK3CA mutations, together with p53 inactivation, results in malignant transformation [15].
Positive_regulation (activation) of AKT associated with malignant neoplastic disease
15) Confidence 0.50 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.60 Pain Relevance 0
PTEN is thought to be inactivated by deletion or mutation and through loss of its negative regulatory effect on AKT, lead to activation of the AKT-pathway, and consequently prevent apoptosis [85, 111].
Positive_regulation (activation) of AKT associated with apoptosis
16) Confidence 0.49 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902045 Disease Relevance 1.96 Pain Relevance 0
Cyclo-oxygenase-2-mediated synthesis of prostaglandin E(2) (PGE(2)) leads to activation of mitogen-activated protein kinase (MAPK), as well as phosphatidylinositol 3-kinase (PI3K)/Akt pathways.
Positive_regulation (activation) of Akt
17) Confidence 0.49 Published 2007 Journal Br. J. Dermatol. Section Abstract Doc Link 17488403 Disease Relevance 1.10 Pain Relevance 0.77
This result suggested that most anti-inflammatory effects of statins are exerted at the post-transcriptional level.29 The study by Shioto30 suggests that many statin pleiotropic effects are through the activation of AKT-mediated pathways.
Positive_regulation (activation) of AKT associated with inflammation
18) Confidence 0.49 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686255 Disease Relevance 0.64 Pain Relevance 0.20
ILK can influence a wide range of cellular processes in development and disease (proliferation, migration, EMT) [4], and many of these effects may be due to its activation of Akt and interaction with the PI3K pathway.
Positive_regulation (activation) of Akt associated with disease
19) Confidence 0.47 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.54 Pain Relevance 0
Treatment of HeLa cells with HDAC inhibitors such as valproic acid and butyrate leads to inhibition of Akt1 and Akt2 expression, consequently to deactivation of cellular Akt (Fig. 1 and 2).
Positive_regulation (deactivation) of Akt in HeLa
20) Confidence 0.46 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.79 Pain Relevance 0

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