INT86219

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Context Info
Confidence 0.41
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 8.99
Pain Relevance 4.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peroxisome (GSTK1) intracellular (GSTK1)
Anatomy Link Frequency
plasma 1
liver 1
erythrocyte 1
lymphocyte 1
heart 1
GSTK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 186 99.98 Very High Very High Very High
Dopamine 92 99.64 Very High Very High Very High
agonist 76 99.52 Very High Very High Very High
Hippocampus 22 99.52 Very High Very High Very High
ischemia 43 98.68 Very High Very High Very High
Glutamate 30 97.28 Very High Very High Very High
aspirin 10 96.64 Very High Very High Very High
diclofenac 4 94.64 High High
acular 4 92.24 High High
cINOD 24 88.08 High High
Disease Link Frequency Relevance Heat
Stress 114 99.82 Very High Very High Very High
Immunotherapy Of Cancer 2 99.34 Very High Very High Very High
Urological Neuroanatomy 22 98.88 Very High Very High Very High
Cv General 4 Under Development 20 98.68 Very High Very High Very High
Middle Cerebral Artery Infarction 56 97.04 Very High Very High Very High
Myocardial Infarction 66 96.88 Very High Very High Very High
Cancer 102 96.84 Very High Very High Very High
Toxicity 75 96.32 Very High Very High Very High
Chronic Lymphoid Leukemia 229 94.72 High High
Second Primary Neoplasms 2 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naproxen, tiaprofenic acid and piroxicam caused a decrease in GST activity at therapeutic doses.
Negative_regulation (decrease) of GST
1) Confidence 0.41 Published 2001 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 11484831 Disease Relevance 0.28 Pain Relevance 0.80
Na-salicylate inhibited GST activity at the therapeutic dose, however activated the same enzyme at high concentrations.
Negative_regulation (inhibited) of GST
2) Confidence 0.41 Published 2001 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 11484831 Disease Relevance 0.30 Pain Relevance 0.75
Sulindac sulfone, a metabolite of sulindac which lacks the ability to inhibit prostaglandin (PG) synthesis, increased QR and GST to 1.5-fold over controls in both cases.
Negative_regulation (inhibit) of GST
3) Confidence 0.37 Published 1999 Journal Cancer Lett. Section Abstract Doc Link 10660094 Disease Relevance 0.24 Pain Relevance 0.46
Assessment of relationships between GST polymorphisms and survival following cancer treatment is based on the hypothesis that reduced GST activity would result in fewer ROS and therapeutic agent metabolites reaching tumor cells, where they could confer protection against damage to DNA, proteins, and lipids.
Negative_regulation (reduced) of GST associated with cancer and immunotherapy of cancer
4) Confidence 0.28 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779469 Disease Relevance 0.62 Pain Relevance 0
To our knowledge, there have been no evaluations of the role of genotypes associated with decreased GST activity and side effects experienced with radiation therapy.
Negative_regulation (decreased) of GST
5) Confidence 0.28 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779469 Disease Relevance 0.42 Pain Relevance 0
Homozygous deletion of the GSTM1 gene eliminates GST activity with respect to conjugation of the characteristic GST M1-1 substrate trans-stilbene oxide (TSO), as measured in lymphocyte homogenates [60–62]; indeed, the phenotypic polymorphism was discovered (with the substrate trans-4-phenyl-3-buten-2-one) before the gene was cloned [63, 64].
Negative_regulation (eliminates) of GST in lymphocyte
6) Confidence 0.28 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0 Pain Relevance 0
Similarly, homozygous deletion of the GSTT1 gene eliminates GST activity with respect to conjugation of the characteristic GST T1-1 substrates methyl bromide (CH3Br) and dichloromethane (CH2Cl2), as measured in erythrocyte homogenates [65, 66].
Negative_regulation (eliminates) of GST in erythrocyte
7) Confidence 0.28 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0.06 Pain Relevance 0
Both animal and plant genomes encode large numbers of GST enzymes (and often, multiple pseudogenes with strong sequence similarity to GST genes), for example, 48 GST genes in the nematode Caenorhabditis elegans [52], 26 in the mosquito Aedes aegypti [53], and more than 70 in the Black Cottonwood poplar Populus trichocarpa [54].
Negative_regulation (numbers) of GST
8) Confidence 0.28 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0 Pain Relevance 0
Therefore, absence of or reduced GST enzyme activities may lead to malfunction in the inactivation of these metabolites, generated during the oxidative stress process, and this may contribute to the development of atherosclerotic CAD.
Negative_regulation (reduced) of GST enzyme associated with stress, coronary artery disease and atherosclerosis
9) Confidence 0.24 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1458325 Disease Relevance 1.41 Pain Relevance 0
Inhibition of the phase II biotransformation enzyme gst in males was proportional to the level of estrogenic activity in the effluents studied.
Negative_regulation (Inhibition) of gst
10) Confidence 0.18 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0.07 Pain Relevance 0
As for the genotoxic effects, however, the strong inhibitory effect of the weakly estrogenic effluent alone (without EE2) on gst levels in males suggests that other chemicals present in the effluent may have also contributed to this observed response.
Negative_regulation (effect) of gst
11) Confidence 0.15 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0.09 Pain Relevance 0.03
The present nematode biosensor is not only a tool to evaluate and discover functional food ingredients but also would be a powerful genetic tool to dissect the GST and UGT expression pathways and to analyze their regulatory mechanisms (Hasegawa, Nonomura, Kondo, and Miwa, unpublished results).
Negative_regulation (dissect) of GST
12) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2822842 Disease Relevance 0.31 Pain Relevance 0
The results summarized in Figure 5, 6, 7 indicate that a toxic dose of APAP lowered the plasma activities of GR, GST and GCS, respectively, and that all the test compounds offered different degrees of protection against such losses.
Negative_regulation (lowered) of GST in plasma associated with paracetamol
13) Confidence 0.08 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0 Pain Relevance 0.76
From the results presented in Figure 6, it can be seen that APAP lowered the liver GST activity by 70% of the control value (p<0.001), and that this effect was effectively reduced by HYTAU (only 12% decrease), TAU (only 31% decrease, p<0.01) and NAC (only 28% decrease, p<0.01).
Negative_regulation (lowered) of GST in liver associated with paracetamol
14) Confidence 0.08 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0 Pain Relevance 0.60
Overall, HLA allele frequencies in São Miguel, mainland Portugal and other European populations demonstrated absence of statistically significant differences (GST = 0.03; data not shown).
Negative_regulation (absence) of GST
15) Confidence 0.05 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883542 Disease Relevance 0 Pain Relevance 0
The authors therefore concluded that the ruthenium centers were also involved in the inhibition of GST P1-1.
Negative_regulation (inhibition) of GST
16) Confidence 0.05 Published 2010 Journal Journal of Medicinal Chemistry Section Body Doc Link PMC3018145 Disease Relevance 0.12 Pain Relevance 0
This was paralleled by significant decline in the activities of glutathione-dependent antioxidant enzymes (GPx and GST) and antiperoxidative enzymes (SOD and CAT) in the heart tissue of Group III myocardial infarction induced rats.
Negative_regulation (decline) of GST in heart associated with myocardial infarction
17) Confidence 0.03 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291504 Disease Relevance 0.10 Pain Relevance 0
The mechanism of EA cytotoxicity was attributed to the drug's known capacity to inhibit glutathione S-transferase (GST), causing increased cellular oxidative stress.
Negative_regulation (inhibit) of GST associated with stress
18) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.91 Pain Relevance 0
-catenin signaling by EA is mediated by modulation of thiols, or by increased oxidative stress as a result of GST inhibition, cells that had been co-transfected with the TOPflash reporter and the Dvl expression plasmids were treated with EA and various antioxidants (NAC, BHA and PDTC).
Negative_regulation (inhibition) of GST associated with stress
19) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.36 Pain Relevance 0
Since EA is able to increase cellular oxidative stress through inhibiting GST, we also tested the effect of two free radical scavengers, BHA and PDTC, on EA-mediated inhibition of Wnt/?
Negative_regulation (inhibiting) of GST associated with stress
20) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2789382 Disease Relevance 0.75 Pain Relevance 0

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