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Context Info
Confidence 0.45
First Reported 1992
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.45
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn11a) plasma membrane (Scn11a) transmembrane transport (Scn11a)
Anatomy Link Frequency
Scn11a (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 9 99.78 Very High Very High Very High
Nerve growth factor 12 99.60 Very High Very High Very High
sodium channel 6 97.38 Very High Very High Very High
Hyperalgesia 1 86.24 High High
Peripheral nervous system 1 85.12 High High
Hippocampus 1 81.20 Quite High
midbrain 1 79.92 Quite High
Thalamus 1 78.40 Quite High
Neuropeptide 1 71.44 Quite High
tetrodotoxin 1 48.64 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 9 99.78 Very High Very High Very High
Convulsion 2 90.48 High High
Hyperalgesia 1 86.24 High High
Hypertrophy 1 83.80 Quite High
Targeted Disruption 2 77.24 Quite High
Epilepsy 2 72.96 Quite High
Sprains And Strains 1 69.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Northern blot hybridization analysis showed excess expression of Na+ channel mRNA (by 30-40%) coincidentally with Na+ channel increases.
Positive_regulation (excess) of Transcription (expression) of Na
1) Confidence 0.45 Published 1992 Journal Neuroscience Section Abstract Doc Link 1376448 Disease Relevance 0.38 Pain Relevance 0.12
Hybridization signals for sodium channel subunits alphaII and beta2 displayed the most substantial enhancement in hyper-NGF mice, compared to wild-type mice DRG, and mRNA levels for alphaI, NaG, Na6, SNS/PN3, NaN, and beta1 were also greater in hyper-NGF DRG.
Positive_regulation (greater) of Transcription (levels) of NaN in DRG associated with dorsal root ganglion, nerve growth factor and sodium channel
2) Confidence 0.22 Published 1999 Journal J. Neurosci. Res. Section Abstract Doc Link 10397634 Disease Relevance 1.07 Pain Relevance 1.25

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