INT8623

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Context Info
Confidence 0.58
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.42
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn11a) plasma membrane (Scn11a) transmembrane transport (Scn11a)
Anatomy Link Frequency
livers 1
DRG 1
Scn11a (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 45 99.78 Very High Very High Very High
Nerve growth factor 12 99.04 Very High Very High Very High
sodium channel 6 97.38 Very High Very High Very High
Nav1.9 4 92.48 High High
Morphine 1 86.84 High High
Hyperalgesia 1 86.24 High High
Peripheral nervous system 1 85.12 High High
qutenza 4 82.64 Quite High
Hippocampus 1 81.20 Quite High
midbrain 1 79.92 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 51 99.78 Very High Very High Very High
Sprains And Strains 257 94.88 High High
Nervous System Injury 38 92.76 High High
Convulsion 2 90.20 High High
Hyperalgesia 1 86.24 High High
Hypertrophy 1 83.80 Quite High
Targeted Disruption 19 77.24 Quite High
Epilepsy 2 72.68 Quite High
Injury 6 70.68 Quite High
Neuropathic Pain 124 44.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oligonucleotide probes were synthesized complementary to the mouse mRNA sequences of the Na+ channel ?
Transcription (sequences) of Na
1) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.46 Pain Relevance 0.28
Northern blot hybridization analysis showed excess expression of Na+ channel mRNA (by 30-40%) coincidentally with Na+ channel increases.
Transcription (expression) of Na
2) Confidence 0.52 Published 1992 Journal Neuroscience Section Abstract Doc Link 1376448 Disease Relevance 0.38 Pain Relevance 0.12
Outlier values for Gal and Scn11a were also found in two AKR mice (one operated, one sham) and in one operated CBA mouse.
Transcription (found) of Scn11a
3) Confidence 0.52 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.53 Pain Relevance 0.09
Hybridization signals for sodium channel subunits alphaII and beta2 displayed the most substantial enhancement in hyper-NGF mice, compared to wild-type mice DRG, and mRNA levels for alphaI, NaG, Na6, SNS/PN3, NaN, and beta1 were also greater in hyper-NGF DRG.
Transcription (levels) of NaN in DRG associated with dorsal root ganglion, nerve growth factor and sodium channel
4) Confidence 0.31 Published 1999 Journal J. Neurosci. Res. Section Abstract Doc Link 10397634 Disease Relevance 1.06 Pain Relevance 1.24
In a separate study, we systematically compared the mRNA expression profiles for 26 phase II h-enzymes, including GST, SUL, NAT, and UGT members, between livers of chimeric mice with RIs of 71–89% and donor livers [16].
Transcription (expression) of NAT in livers
5) Confidence 0.11 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0 Pain Relevance 0.09

General Comments

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