INT8624

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Context Info
Confidence 0.46
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.56
Pain Relevance 4.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn11a) plasma membrane (Scn11a) transmembrane transport (Scn11a)
Anatomy Link Frequency
neurons 1
skeleton 1
afferent neuron 1
Scn11a (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 13 100.00 Very High Very High Very High
lidocaine 8 99.92 Very High Very High Very High
nav1.8 1 99.84 Very High Very High Very High
Antinociceptive 2 99.48 Very High Very High Very High
Inflammatory mediators 4 99.40 Very High Very High Very High
Migraine 11 99.30 Very High Very High Very High
Inflammation 7 98.78 Very High Very High Very High
depression 1 98.48 Very High Very High Very High
sodium channel 16 98.42 Very High Very High Very High
Nav1.9 1 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 9 99.72 Very High Very High Very High
INFLAMMATION 11 99.40 Very High Very High Very High
Epilepsy 3 99.40 Very High Very High Very High
Headache 4 99.30 Very High Very High Very High
Depression 1 98.48 Very High Very High Very High
Nociception 10 95.36 Very High Very High Very High
Neuropathic Pain 1 91.88 High High
Ganglion Cysts 36 91.16 High High
Convulsion 2 87.68 High High
Nervous System Injury 2 85.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the antinociceptive efficacy of lidocaine is increased in Na(v)1.8-knockout mice.
Positive_regulation (increased) of Na associated with targeted disruption, lidocaine and antinociceptive
1) Confidence 0.46 Published 2010 Journal Pflugers Arch. Section Abstract Doc Link 20174994 Disease Relevance 0.83 Pain Relevance 1.26
Northern blot hybridization analysis showed excess expression of Na+ channel mRNA (by 30-40%) coincidentally with Na+ channel increases.
Positive_regulation (increases) of Na
2) Confidence 0.45 Published 1992 Journal Neuroscience Section Abstract Doc Link 1376448 Disease Relevance 0.37 Pain Relevance 0.18
These studies show the following: (1) FHM1 mutations produce gain-of-function of the Ca(V)2.1 channel and, as a consequence, increased Ca(V)2.1-dependent neurotransmitter release from cortical neurons and facilitation of in vivo induction and propagation of cortical spreading depression (CSD: the phenomenon underlying migraine aura); (2) FHM2 mutations produce loss-of-function of the alpha2 Na+,K+-ATPase; and (3) the FHM3 mutation accelerates recovery from fast inactivation of Na(V)1.5 (and presumably Na(V)1.1) channels.
Positive_regulation (loss-of-function) of Na in neurons associated with epilepsy, neurotransmitter, depression and migraine
3) Confidence 0.07 Published 2007 Journal Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics Section Abstract Doc Link 17395138 Disease Relevance 0.91 Pain Relevance 0.91
The nomenclature of SNS sodium channels is rather confusing, with SNS1 also referred to as PN3, NaNG or Nav1.8, while SNS2 is sometimes referred to as the NaN, SNS2, PN5, NaT, SCN12A or Nav1.9 channel.
Positive_regulation (referred) of SNS2 associated with sodium channel, nav1.8 and nav1.9
4) Confidence 0.05 Published 2001 Journal Respir Res Section Body Doc Link PMC59581 Disease Relevance 0.19 Pain Relevance 1.12
Hence, the contribution of Na(V)1.9 to the PGE(2)-induced upregulation of TTX-R Na(+) current remains to be elucidated.
Positive_regulation (upregulation) of Na
5) Confidence 0.05 Published 2007 Journal J. Pharmacol. Sci. Section Abstract Doc Link 17220592 Disease Relevance 0.58 Pain Relevance 0.49
One possible mechanism underlying inflammation-induced sensitization of the primary afferent neuron is the upregulation of tetrodotoxin-resistant (TTX-R) Na(+) current by inflammatory mediators such as prostaglandins.
Positive_regulation (upregulation) of Na in afferent neuron associated with tetrodotoxin, inflammatory mediators and inflammation
6) Confidence 0.05 Published 2007 Journal J. Pharmacol. Sci. Section Abstract Doc Link 17220592 Disease Relevance 0.44 Pain Relevance 0.39
The cardiac voltage-gated Na+ channel Nav1.5, encoded by SCN5A gene, determines the upstroke velocity of the action potential and, in conjunction with gap junction channels and the organization of the collagenous skeleton, controls the propagation of the cardiac electrical impulse.
Positive_regulation (gated) of Na in skeleton associated with action potential
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.24 Pain Relevance 0.05

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