INT86245

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Context Info
Confidence 0.46
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 12.67
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Bcl2l1) cytosol (Bcl2l1) mitochondrion (Bcl2l1)
growth (Bcl2l1) cytoskeleton (Bcl2l1) intracellular (Bcl2l1)
Anatomy Link Frequency
liver 2
colon 1
mature B cells 1
osteoclast 1
epithelial cells 1
Bcl2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 30 98.96 Very High Very High Very High
Leflunomide 10 97.32 Very High Very High Very High
Inflammatory response 11 91.68 High High
antagonist 11 91.04 High High
Inflammation 119 87.76 High High
Clonidine 3 82.84 Quite High
positron emission tomography 8 76.00 Quite High
chemokine 34 75.24 Quite High
cerebral cortex 2 75.00 Quite High
Analgesic 1 53.68 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 151 100.00 Very High Very High Very High
Hypoxia 15 99.90 Very High Very High Very High
Death 44 99.88 Very High Very High Very High
Ureteral Obstruction 42 99.60 Very High Very High Very High
Hepatotoxicity 6 99.44 Very High Very High Very High
Metastasis 34 99.38 Very High Very High Very High
Breast Cancer 7 98.88 Very High Very High Very High
Colon Cancer 33 98.16 Very High Very High Very High
Injury 25 97.28 Very High Very High Very High
Hyperplasia 3 95.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This investigation examined whether some aspects of the highly integrated process of acetaminophen (AAP)-induced hepatotoxicity involve down-regulation or upregulation of expression of BCL-2, BCL-X(L) and BCL-X(S) in mouse liver in vivo.
Positive_regulation (upregulation) of BCL-X in liver associated with paracetamol and hepatotoxicity
1) Confidence 0.46 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 0.72 Pain Relevance 0.47
This investigation examined whether some aspects of the highly integrated process of acetaminophen (AAP)-induced hepatotoxicity involve down-regulation or upregulation of expression of BCL-2, BCL-X(L) and BCL-X(S) in mouse liver in vivo.
Positive_regulation (upregulation) of BCL-X in liver associated with paracetamol and hepatotoxicity
2) Confidence 0.46 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 0.72 Pain Relevance 0.47
There was constitutive activation of Stat5 and detectable expression of the Stat5 target Bcl-XL in BM of both normal and polycythemic mice, with increased Stat5 phosphorylation and Bcl-XL in spleens from JAKV617F recipients, although this could in part reflect the increase in splenic myeloerythroid cells in these mice.
Positive_regulation (increased) of Bcl-XL in spleens
3) Confidence 0.34 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.25 Pain Relevance 0
Instead, leflunomide inhibited APAP-induced activation (phosphorylation) of c-jun NH2-terminal protein kinase (JNK), thus preventing downstream Bcl-2 and Bcl-XL inactivation and protecting from mitochondrial permeabilization and cytochrome c release.
Positive_regulation (protecting) of Bcl-XL associated with paracetamol and leflunomide
4) Confidence 0.26 Published 2007 Journal Hepatology Section Abstract Doc Link 17366662 Disease Relevance 0.49 Pain Relevance 1.34
B–mediated upregulation of antiapoptotic bcl-2, bcl-xL, and bfl-1/A1 genes [7,9].
Positive_regulation (upregulation) of bcl-xL
5) Confidence 0.25 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.51 Pain Relevance 0
This less pronounced increase in the Bax/Bcl-xL ratio in UUO-kidneys of Mas?
Positive_regulation (increase) of Bcl-xL associated with ureteral obstruction
6) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672164 Disease Relevance 1.37 Pain Relevance 0.09
The correlation between lapatinib-induced cell death, Bak activation and Bcl-xL downregulation has been described as well in colon cancer cells [29].
Positive_regulation (activation) of Bcl-xL in colon associated with colon cancer and death
7) Confidence 0.22 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 1.33 Pain Relevance 0.04
B functions in mature B cells as a survival factor by mediating the upregulation of several antiapoptotic proteins, including A1, Bcl-2, and Bcl-xL [7,57].
Positive_regulation (upregulation) of Bcl-xL in mature B cells
8) Confidence 0.21 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.35 Pain Relevance 0
Macrophage CSF is a survival factor for osteoclast precursors due to upregulating Bcl-XL, inhibiting caspase-9 activation [22], and supporting mature osteoclast survival by preventing apoptosis [23].
Positive_regulation (upregulating) of Bcl-XL in osteoclast associated with apoptosis
9) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592787 Disease Relevance 0.24 Pain Relevance 0
However, our results could be explained, at least in part, by the fact that levels of the antiapoptotic-associated proteins such as activated AKT, Bcl-2, Bcl-xL and surviving, as well as the cell cycle-associated protein cyclin D1, were strongly decreased (Figure 7) indicating that apoptosis and cell cycle are regulated by reg4.
Positive_regulation (activated) of Bcl-xL associated with apoptosis
10) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760775 Disease Relevance 0.88 Pain Relevance 0
Kochetkova and colleagues showed that transient CXCL12 stimulation increased tumor metastasis by inhibiting anoikis through induction of Bmf and Bcl-XL anti-apoptotic proteins in breast cancer cells [25].
Positive_regulation (induction) of Bcl-XL associated with breast cancer, apoptosis and metastasis
11) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.05 Pain Relevance 0.13
The blockage of EGFR and STAT3-signaling cascades seemingly increased the levels of p53, Bax and decreased levels of Bcl-xL, survivin, and cyclin D1 proteins.
Positive_regulation (increased) of Bcl-xL
12) Confidence 0.13 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 1.06 Pain Relevance 0
One possibility is that BAD provides a counterbalance for increased levels of BclXL and Bcl-2 that are known to slow proliferation [22].
Positive_regulation (increased) of BclXL
13) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2704953 Disease Relevance 0.62 Pain Relevance 0.09
B signaling in epithelial cells was required for inhibition of apoptosis shortly after administration of one round of AOM and DSS, perhaps by the induction of anti-apoptotic factors such as Bcl-XL.
Positive_regulation (induction) of Bcl-XL in epithelial cells associated with apoptosis
14) Confidence 0.11 Published 2007 Journal Yale J Biol Med Section Body Doc Link PMC1994795 Disease Relevance 1.35 Pain Relevance 0.21
We propose that during hypoxia the increased ratio of (pro-apoptotic Bad and Bax/anti-apoptotic Bcl-xl and Bcl-2) in all the three compartments, will lead to altered mitochondrial and nuclear membrane permeability as well as caspase-9 activation in the cytosolic compartment.
Positive_regulation (increased) of Bcl-xl associated with hypoxia and apoptosis
15) Confidence 0.05 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 18293086 Disease Relevance 1.73 Pain Relevance 0.28

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