INT86247

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Context Info
Confidence 0.34
First Reported 2000
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 12.21
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Bcl2l10) mitochondrion (Bcl2l10) nucleus (Bcl2l10)
Anatomy Link Frequency
bladder 2
Bcl2l10 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 60 98.96 Very High Very High Very High
Paracetamol 9 98.44 Very High Very High Very High
antagonist 7 92.80 High High
agonist 9 89.60 High High
imagery 17 85.84 High High
cINOD 41 84.08 Quite High
cerebral cortex 9 82.52 Quite High
tetrodotoxin 8 69.52 Quite High
sodium channel 1 66.32 Quite High
transdermal 7 50.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 372 100.00 Very High Very High Very High
Overactive Bladder 81 100.00 Very High Very High Very High
Cancer 377 99.84 Very High Very High Very High
Non-genital Cutaneous Warts 2 99.76 Very High Very High Very High
Stress 14 99.28 Very High Very High Very High
Infection 31 98.20 Very High Very High Very High
Death 68 97.56 Very High Very High Very High
Immunotherapy Of Cancer 3 97.24 Very High Very High Very High
Malignant Neoplastic Disease 9 96.20 Very High Very High Very High
Hypertension 36 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The anti-apoptotic protein survivin was not expressed in normal bladder epithelium, but was variably expressed in cancers.
Gene_expression (expressed) of anti-apoptotic protein in bladder associated with cancer and apoptosis
1) Confidence 0.34 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15591090 Disease Relevance 0.78 Pain Relevance 0
The anti-apoptotic protein survivin was not expressed in normal bladder epithelium, but was variably expressed in cancers.
Neg (not) Gene_expression (expressed) of anti-apoptotic protein in bladder associated with cancer and apoptosis
2) Confidence 0.34 Published 2005 Journal Carcinogenesis Section Abstract Doc Link 15591090 Disease Relevance 0.77 Pain Relevance 0
However, this study may have demonstrated for the first time drug-induced changes in the expression of anti-apoptotic gene BCL-X(L), and a positive link between AAP-induced apoptotic death and modification of BCL-X(L) protein in vivo.
Gene_expression (expression) of anti-apoptotic gene associated with paracetamol, apoptosis and death
3) Confidence 0.20 Published 2000 Journal Arch. Toxicol. Section Abstract Doc Link 10663392 Disease Relevance 0.88 Pain Relevance 0.38
We determined the expression of pro-apoptotic protein Bax and anti-apoptotic protein Bcl-2 after treatment of morphine and H37Ra infection.
Spec (determined) Gene_expression (expression) of anti-apoptotic protein associated with apoptosis, infection and morphine
4) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 0.94 Pain Relevance 0.72
The reason of this might be due to more apoptosis at 48 h in HepG2 cells negatively feedback to inhibit the ratio of Bax/Bcl-2 via enhancing the expression of anti-apoptotic protein.


Gene_expression (expression) of anti-apoptotic protein associated with apoptosis
5) Confidence 0.10 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2222640 Disease Relevance 0.93 Pain Relevance 0
Our results indicate that embryonic cortical precursors are heterogeneous with respect to cell surface Fas expression and the co-expression of the anti-apoptotic protein FLIP (FLICE/caspase-8 interacting protein).
Gene_expression (expression) of anti-apoptotic protein associated with apoptosis
6) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.41 Pain Relevance 0.07
As the above-described characteristics established survivin as a potential target for anticancer therapy, we investigated whether the expression of this anti-apoptotic protein could be restrained by celecoxib and DMC.
Gene_expression (expression) of anti-apoptotic protein associated with apoptosis
7) Confidence 0.03 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 1.25 Pain Relevance 0
We present evidence that celecoxib and DMC are able to down-regulate the expression of survivin, an anti-apoptotic protein that is highly expressed in tumor cells and known to confer resistance of such cells to anti-cancer treatments.
Gene_expression (expression) of anti-apoptotic protein associated with cancer, apoptosis and immunotherapy of cancer
8) Confidence 0.03 Published 2006 Journal Mol Cancer Section Abstract Doc Link PMC1479836 Disease Relevance 0.75 Pain Relevance 0.08
We present evidence that celecoxib and DMC are able to down-regulate the expression of survivin, an anti-apoptotic protein that is highly expressed in tumor cells and known to confer resistance of such cells to anti-cancer treatments.
Gene_expression (expressed) of anti-apoptotic protein associated with cancer, apoptosis and immunotherapy of cancer
9) Confidence 0.03 Published 2006 Journal Mol Cancer Section Abstract Doc Link PMC1479836 Disease Relevance 0.75 Pain Relevance 0.08
1 expression induces apoptosis, the expression of Bcl2, an anti-apoptotic protein, which has been shown to promote the survival of cancer cells [40] was evaluated.
Gene_expression (expression) of anti-apoptotic protein associated with cancer and apoptosis
10) Confidence 0.02 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2614423 Disease Relevance 1.30 Pain Relevance 0
The expression of the anti-apoptotic molecule galectin-3 is restricted to cancer cells and this feature has potential diagnostic and therapeutic implications.
Gene_expression (expression) of anti-apoptotic associated with cancer and apoptosis
11) Confidence 0.02 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2582451 Disease Relevance 0.85 Pain Relevance 0.11
We examined the levels of Bcl-2, an anti-apoptotic protein, since oxidative stress results in the activation of multiple signaling cascades that ultimately dictate the outcome for cell survival.
Spec (examined) Gene_expression (levels) of anti-apoptotic protein associated with stress and apoptosis
12) Confidence 0.02 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635644 Disease Relevance 0.98 Pain Relevance 0
At elevated concentrations, OA acts as an apoptogen and promotes expression of the proapoptotic caspase gene with a simultaneous down-regulation of the expression of the anti-apoptotic Bcl-2 homolog gene.
Gene_expression (expression) of anti-apoptotic Bcl-2 homolog gene associated with apoptosis
13) Confidence 0.01 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2810222 Disease Relevance 0.19 Pain Relevance 0.10
If patients have mixed OAB and BOO, it is recommended that they be treated with antimuscarinics and ?
Gene_expression (mixed) of BOO associated with overactive bladder
14) Confidence 0.01 Published 2008 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228367 Disease Relevance 1.02 Pain Relevance 0.05
Western blot analysis showed that EPO administration led to a higher expression of the anti-apoptotic gene Bcl-xL at 24 h after hepatectomy when compared with vehicle-treated controls (figure 2A).
Gene_expression (expression) of anti-apoptotic gene associated with apoptosis
15) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2592699 Disease Relevance 0.40 Pain Relevance 0

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