INT86257

Context Info Confidence 0.41 First Reported 2000 Last Reported 2000 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.82

Anatomy Mention Frequency striatum 2

Pain Term Frequency Confidence Heat Raphe 3 100.00 cerebral cortex 1 98.40 fluoxetine 6 96.92 Serotonin 1 88.52 Potency 1 83.76 agonist 1 82.00 Pyramidal cell 1 69.60 Hippocampus 1 67.76

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, a significant decrease (-38%) in 5-HT1A mRNA levels in the anterior raphe area (but not forebrain regions) and increases in 5-HT1B mRNA levels in the striatum (+127%) and the cerebral cortex (+34%) were noted in fluoxetine-treated rats.

Negative_regulation (decrease) of Positive_regulation (increases) of 5-HT1B mRNA in striatum associated with cerebral cortex, raphe and fluoxetine

1) Confidence 0.41 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10665824 Disease Relevance 0 Pain Relevance 0.82

General Comments

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