INT86264

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Context Info
Confidence 0.33
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.76
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HIVEP1) intracellular (HIVEP1) plasma membrane (OPRK1)
DNA binding (HIVEP1) cytoplasm (HIVEP1) signal transducer activity (OPRK1)
Anatomy Link Frequency
microglial cell 4
OPRK1 (Homo sapiens)
HIVEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 6 100.00 Very High Very High Very High
agonist 2 100.00 Very High Very High Very High
antagonist 2 73.76 Quite High
nMDA receptor antagonist 2 63.76 Quite High
Opioid 2 36.40 Quite Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 18 100.00 Very High Very High Very High
Encephalopathy 4 93.44 High High
Drug Induced Neurotoxicity 4 85.76 High High
Infection 2 58.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The kappa opioid receptor (KOR) agonist U50,488 recently has been shown to inhibit HIV-1 p24 antigen production in acutely infected microglial cell cultures.
kappa opioid receptor Negative_regulation (inhibit) of Gene_expression (production) of HIV-1 p24 in microglial cell associated with acquired immune deficiency syndrome or hiv infection, agonist and kappa opioid receptor
1) Confidence 0.33 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10665828 Disease Relevance 0.88 Pain Relevance 0.26
The kappa opioid receptor (KOR) agonist U50,488 recently has been shown to inhibit HIV-1 p24 antigen production in acutely infected microglial cell cultures.
KOR Negative_regulation (inhibit) of Gene_expression (production) of HIV-1 p24 in microglial cell associated with acquired immune deficiency syndrome or hiv infection, agonist and kappa opioid receptor
2) Confidence 0.33 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10665828 Disease Relevance 0.88 Pain Relevance 0.26

General Comments

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