INT86280

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Context Info
Confidence 0.62
First Reported 2000
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 6.56
Pain Relevance 3.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Nfasc) plasma membrane (Nfasc)
Anatomy Link Frequency
neurons 2
facial nerve 1
macrophages 1
brain 1
neuropil 1
Nfasc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 3 99.44 Very High Very High Very High
Enkephalin 3 99.28 Very High Very High Very High
diabetic neuropathy 16 98.64 Very High Very High Very High
Inflammatory response 2 98.36 Very High Very High Very High
anesthesia 7 97.80 Very High Very High Very High
chemokine 6 97.36 Very High Very High Very High
dorsal root ganglion 31 96.76 Very High Very High Very High
fluoxetine 2 96.52 Very High Very High Very High
Pain 33 96.24 Very High Very High Very High
Neuropeptide 1 93.36 High High
Disease Link Frequency Relevance Heat
Anorexia 1 100.00 Very High Very High Very High
Stress 7 99.76 Very High Very High Very High
Infection 13 99.58 Very High Very High Very High
Diabetic Neuropathy 16 98.64 Very High Very High Very High
INFLAMMATION 38 98.36 Very High Very High Very High
Appetite Loss 6 96.88 Very High Very High Very High
Ganglion Cysts 32 96.76 Very High Very High Very High
Dengue 3 96.72 Very High Very High Very High
Pain 42 96.24 Very High Very High Very High
Diabetes Mellitus 4 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the concentration of DMSO was increased (NF-9 to NF-11), the release of NF increased from 43.12% to 62.66% at 24 hours (Fig. 4).
Positive_regulation (increased) of NF-9
1) Confidence 0.62 Published 2010 Journal Eplasty Section Body Doc Link PMC2890388 Disease Relevance 0 Pain Relevance 0.07
The gradual increase in concentration of DMSO in the plasters NF-9 to NF-11 resulted in marginal increase in the thickness of the plasters.
Positive_regulation (increase) of NF-9
2) Confidence 0.45 Published 2010 Journal Eplasty Section Body Doc Link PMC2890388 Disease Relevance 0.31 Pain Relevance 0.17
The gradual increase in concentration of DMSO in the plasters NF-9 to NF-11 resulted in marginal increase in the thickness of the plasters.
Positive_regulation (increase) of NF-11
3) Confidence 0.45 Published 2010 Journal Eplasty Section Body Doc Link PMC2890388 Disease Relevance 0.31 Pain Relevance 0.17
The present findings showing an increased amount of 200 kDa NF immunoreactivity, the major protein of the neuronal cytoskeletal intermediate filament, in the cell bodies and neuropil of axotomized facial neurons are in accordance with previous publications that have demonstrated a remarkable regenerative capacity of motoneurons following axotomy in adult rodents and human beings [41].
Positive_regulation (increased) of NF in neuropil
4) Confidence 0.12 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.09 Pain Relevance 0
Both dF and dNF anorexias were enhanced in rats with 5,7-DHT lesions.
Positive_regulation (enhanced) of dNF associated with anorexia
5) Confidence 0.12 Published 2000 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 10666140 Disease Relevance 0.53 Pain Relevance 0.31
Tetzlaff and co-workers [42,43] have demonstrated increased syntheses of the cytoskeletal proteins actin and tubulin after axotomy of the rat facial nerve simultaneously to the enhanced NF contents and a low regulation of NF synthesis.
Positive_regulation (enhanced) of NF in facial nerve
6) Confidence 0.11 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.07 Pain Relevance 0.03
This upregulation required protein synthesis and activation of NF-?
Positive_regulation (activation) of NF
7) Confidence 0.11 Published 2009 Journal Mol Pain Section Body Doc Link PMC2698898 Disease Relevance 0.46 Pain Relevance 0.42
Region-specific increases in brain levels of APP, neurofilament-70 (NF-70), and platelet-activating factor receptor (PAF-R) were found in EC rats.
Positive_regulation (increases) of NF-70 in brain
8) Confidence 0.10 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12492435 Disease Relevance 0.42 Pain Relevance 0.22
All c-Fos-positive neurons were immunoreactive for NOS, VIP, NPY and NF 145, but not for SP, ENK, GRP and CALB.
Positive_regulation (immunoreactive) of NF 145 in neurons associated with enkephalin and substance p
9) Confidence 0.05 Published 2003 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 12588467 Disease Relevance 0 Pain Relevance 0.78
We found that compared to the contralateral uninjured side, PSNL induced a large increase in the level of ATF3/NF-200 (Figure 2A) and ATF3/peripherin (Figure 2B) with about 25-30% of NF-200 neurons containing ATF+ nuclei and about 28-34% of peripherin neurons containing ATF+ nuclei in the DRGs ipsilateral to the PSNL (left side).
Positive_regulation (increase) of NF-200 in neurons
10) Confidence 0.02 Published 2011 Journal Mol Pain Section Body Doc Link PMC3022745 Disease Relevance 0.49 Pain Relevance 0.37
This suggests that, in diabetic neuropathy, AGEs and AGE/RAGE interactions induce oxidative stress, result in upregulation of nuclear factor (NF)-kappaB and various NF-kappaB-mediated proinflammatory genes, and exaggerate neurological dysfunction, including altered pain sensation.
Positive_regulation (upregulation) of NF associated with stress, pain, anesthesia and diabetic neuropathy
11) Confidence 0.02 Published 2008 Journal Curr. Pharm. Des. Section Abstract Doc Link 18473845 Disease Relevance 1.51 Pain Relevance 0.55
This suggests that, in diabetic neuropathy, AGEs and AGE/RAGE interactions induce oxidative stress, result in upregulation of nuclear factor (NF)-kappaB and various NF-kappaB-mediated proinflammatory genes, and exaggerate neurological dysfunction, including altered pain sensation.
Positive_regulation (upregulation) of NF associated with stress, pain, anesthesia and diabetic neuropathy
12) Confidence 0.01 Published 2008 Journal Curr. Pharm. Des. Section Abstract Doc Link 18473845 Disease Relevance 1.50 Pain Relevance 0.55
IL-8 induction by DEN2V infection was associated with activation of NF- kappa B and activator protein-1 (AP-1) in HEK293A cells but only with activation of AP-1 in HepG2 cells.
Positive_regulation (activation) of NF associated with infection
13) Confidence 0.01 Published 2006 Journal J. Infect. Dis. Section Abstract Doc Link 16544247 Disease Relevance 0.62 Pain Relevance 0.09
Nuclear factor (NF)-kappaB activation is a critical step in the triggering of inflammatory responses by macrophages.
Positive_regulation (activation) of NF in macrophages associated with inflammatory response
14) Confidence 0.00 Published 2009 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 18775507 Disease Relevance 0.25 Pain Relevance 0.13

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