INT8629

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Context Info
Confidence 0.69
First Reported 1986
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 72
Total Number 75
Disease Relevance 40.66
Pain Relevance 12.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL7A1) cell adhesion (COL7A1)
Anatomy Link Frequency
myocardium 2
plasma 2
fibroblasts 2
platelets 2
annulus 2
COL7A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 111 100.00 Very High Very High Very High
Arthritis 56 99.98 Very High Very High Very High
ischemia 4 99.92 Very High Very High Very High
Inflammation 457 99.90 Very High Very High Very High
fibrosis 484 99.76 Very High Very High Very High
nociceptor 4 99.28 Very High Very High Very High
aspirin 32 99.24 Very High Very High Very High
Pain 82 98.92 Very High Very High Very High
cINOD 36 98.80 Very High Very High Very High
Gabapentin 8 98.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 491 100.00 Very High Very High Very High
Wound Healing 320 100.00 Very High Very High Very High
Adhesions 87 100.00 Very High Very High Very High
Experimental Arthritis 14 100.00 Very High Very High Very High
Arthritis 48 99.98 Very High Very High Very High
Cv Unclassified Under Development 5 99.92 Very High Very High Very High
INFLAMMATION 496 99.90 Very High Very High Very High
Hyperplasia 22 99.82 Very High Very High Very High
Adenocarcinoma 18 99.78 Very High Very High Very High
Fibrosis 210 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our studies show that the glycation of human corneal and scleral collagen produces increases in the collagen intermolecular spacing-these increases are similar to those we previously reported on the ageing of collagen in these tissues.
Positive_regulation (increases) of collagen associated with aging
1) Confidence 0.69 Published 1996 Journal Age Ageing Section Abstract Doc Link 8831872 Disease Relevance 0.73 Pain Relevance 0.11
This results in faster cell division, rapid matrix production (increased collagen, myofibroblasts, etc.), and cell movement.
Positive_regulation (increased) of collagen
2) Confidence 0.69 Published 1999 Journal J Mass Dent Soc Section Abstract Doc Link 10740521 Disease Relevance 0.16 Pain Relevance 0
The total number of neurons in the myenteric plexus is decreased, and collagen deposited in the distal colon is increased with aging in humans.
Positive_regulation (increased) of collagen in colon
3) Confidence 0.69 Published 2000 Journal J Am Geriatr Soc Section Body Doc Link 10983917 Disease Relevance 0.10 Pain Relevance 0
CONCLUSIONS: Except for a very limited margin (1-2 mm) around the catheter, the temperature necessary to induce collagen shrinkage was not observed within the disc.
Positive_regulation (induce) of collagen in margin
4) Confidence 0.69 Published 2003 Journal Spine Section Body Doc Link 12897495 Disease Relevance 0 Pain Relevance 0
RESULTS: There is an age-related progressive increase in collagen and mature and elaunin elastic fibers responsible to elasticity.
Positive_regulation (increase) of collagen
5) Confidence 0.69 Published 2002 Journal Spine J Section Body Doc Link 14588289 Disease Relevance 0 Pain Relevance 0
The present study demonstrates that chronically injured Achilles tendons respond to 12 weeks of eccentric training by increasing collagen synthesis rate.
Positive_regulation (increasing) of collagen in tendons
6) Confidence 0.68 Published 2007 Journal Scand J Med Sci Sports Section Abstract Doc Link 16787448 Disease Relevance 0.16 Pain Relevance 0.09
Till now the link between IBD and cardiovascular diseases has been reported only in few published cases, but none of them has focused the attention on the possible increased collagen deposition far from the main target organ.
Spec (possible) Positive_regulation (increased) of collagen associated with inflammatory bowel disease and cardiovascular disease
7) Confidence 0.67 Published 2002 Journal BMC Public Health Section Body Doc Link PMC128828 Disease Relevance 0.52 Pain Relevance 0.03
In particular, interstitial collagen, because of its acoustic impedance, has been proven to be the main determinant for the echo texture image from the myocardium [24,25], and quantitative analysis of the ultrasound signals from the myocardium has demonstrated increased sensitivity for detection of collagen accumulation [26-28].
Positive_regulation (accumulation) of collagen in myocardium
8) Confidence 0.67 Published 2002 Journal BMC Public Health Section Body Doc Link PMC128828 Disease Relevance 0.05 Pain Relevance 0
Because increased myocardial collagen deposition is a recognized marker of pathologic structural remodelling, at this respect, from this study protocol we expect additional information about what happens at the heart level after a long standing history of IBD and to elucidate whether or not the surgical option could arrest an evenctual cardiac damage.


Positive_regulation (increased) of collagen in heart associated with inflammatory bowel disease
9) Confidence 0.67 Published 2002 Journal BMC Public Health Section Body Doc Link PMC128828 Disease Relevance 0.53 Pain Relevance 0.04
There is a massive accumulation of collagen in the scar tissue but investigations in the embryonic ulcers that healed without scar have shown that collagen organization plays a more important role in the development of the scar than collagen deficiency.
Positive_regulation (accumulation) of collagen associated with cicatrix, osteogenesis imperfecta and ulcers
10) Confidence 0.65 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1891315 Disease Relevance 1.39 Pain Relevance 0.04
A significant and inverse correlation was demonstrated between MMP-9 after 24 h and accumulation levels of collagen in the ePTFE tube 10 days after implantation in the wound.
Positive_regulation (accumulation) of collagen in tube associated with injury
11) Confidence 0.60 Published 2003 Journal APMIS Suppl. Section Abstract Doc Link 14625992 Disease Relevance 0.83 Pain Relevance 0.05
Non-smoking volunteers were found to specifically accumulate more collagen (median value 82%) than smokers matched for age and gender.
Positive_regulation (accumulate) of collagen associated with nicotine addiction
12) Confidence 0.60 Published 2003 Journal APMIS Suppl. Section Abstract Doc Link 14625992 Disease Relevance 0.80 Pain Relevance 0.04
Irrespective of the smoking status women accumulated significantly more collagen in the model than men.
Positive_regulation (accumulated) of collagen associated with nicotine addiction
13) Confidence 0.60 Published 2003 Journal APMIS Suppl. Section Abstract Doc Link 14625992 Disease Relevance 0.81 Pain Relevance 0.05
In contrast, adenocarcinoma G3 had an increased tissue collagen content (by about 60%), decreased percentage of collagen degradation products and similar gelatinolytic activity, compared to normal lung.
Positive_regulation (increased) of collagen in lung associated with adenocarcinoma
14) Confidence 0.50 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12044784 Disease Relevance 0.88 Pain Relevance 0.25
The diameter of the collagen fiber bundles was reduced and the diameter of collagen fibrils was increased.
Positive_regulation (increased) of collagen
15) Confidence 0.50 Published 1986 Journal Arch Surg Section Abstract Doc Link 3741101 Disease Relevance 0.92 Pain Relevance 0.13
Additionally, there were no histological changes in the posterior annulus that were consistent with heat-induced changes to collagen structure.
Positive_regulation (changes) of collagen in annulus
16) Confidence 0.50 Published 2008 Journal Pain Med Section Body Doc Link 18254769 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: Temperatures sufficient for collagen denaturation and nociceptive ablation were detected at distances greater than previously documented.
Positive_regulation (sufficient) of collagen
17) Confidence 0.50 Published 2004 Journal Spine Section Body Doc Link 15131441 Disease Relevance 0 Pain Relevance 0
SETTING AND INTERVENTIONS: Radiofrequency ablation of the disc posterior annulus is a theoretically plausible technique to ablate the nociceptors and to modify collagen of the annulus fibrosus.
Positive_regulation (modify) of collagen in annulus associated with nociceptor
18) Confidence 0.46 Published 2008 Journal Pain Med Section Abstract Doc Link 18254769 Disease Relevance 0.16 Pain Relevance 0.23
The histologic findings of transmural inflammation consisting of lymphocytic infiltration, accumulation of partially hyalinized collagen, and fibrosis in the skip areas from the ileum to the cecum were compatible with Crohn's disease.
Positive_regulation (accumulation) of collagen in cecum associated with fibrosis, crohn's disease, inflammation and disease
19) Confidence 0.46 Published 1998 Journal Nihon Hoigaku Zasshi Section Abstract Doc Link 9780667 Disease Relevance 1.60 Pain Relevance 0.45
It has been shown that collagen cross-linking increases the biomechanical rigidity of the cornea by 4.5 times.[21] By increasing the biomechanical stability of the cornea using the riboflavin and UV-A-induced collagen cross-linking, it is possible to stop the progression of keratoconus.
Positive_regulation (induced) of collagen in cornea associated with corneal disease
20) Confidence 0.45 Published 2009 Journal Oman Journal of Ophthalmology Section Body Doc Link PMC3018104 Disease Relevance 0.28 Pain Relevance 0

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