INT86291

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 33
Total Number 34
Disease Relevance 20.38
Pain Relevance 10.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp2) extracellular space (Mmp2) extracellular region (Mmp2)
proteinaceous extracellular matrix (Mmp2) plasma membrane (Mmp2) nucleus (Mmp2)
Anatomy Link Frequency
fibroblasts 4
hepatocytes 1
cartilage 1
cleavage 1
spinal 1
Mmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 658 100.00 Very High Very High Very High
cINOD 17 99.98 Very High Very High Very High
addiction 4 99.92 Very High Very High Very High
Hyperalgesia 9 99.90 Very High Very High Very High
Cannabinoid 228 99.84 Very High Very High Very High
Morphine 14 99.48 Very High Very High Very High
tolerance 3 98.44 Very High Very High Very High
ischemia 38 97.92 Very High Very High Very High
fibrosis 179 95.40 Very High Very High Very High
Arthritis 117 95.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1180 99.98 Very High Very High Very High
Morphine Dependence 2 99.92 Very High Very High Very High
Hyperalgesia 9 99.90 Very High Very High Very High
INFLAMMATION 296 99.86 Very High Very High Very High
Hepatocellular Cancer 232 99.78 Very High Very High Very High
Arthropathy 5 99.60 Very High Very High Very High
Sarcoma 29 99.48 Very High Very High Very High
Sprains And Strains 13 99.36 Very High Very High Very High
Hajdu-cheney Syndrome 4 99.06 Very High Very High Very High
Apoptosis 114 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intraperitoneal injection of either ZnCl(2) (100 microM), thymulin (5 microg/100 microl), or morphine (2 mg/kg/100 microl) reversed the ET-induced hyperalgesia and suppressed gelatinase activity.
Negative_regulation (suppressed) of gelatinase associated with hyperalgesia and morphine
1) Confidence 0.57 Published 2000 Journal Pain Section Abstract Doc Link 10666546 Disease Relevance 0.74 Pain Relevance 0.89
We therefore performed an assay to investigate the ability of Marimastat to inhibit gelatinase (MMP-2, MMP-9) and interstitial collagenase (MMP-1) activities.
Negative_regulation (inhibit) of MMP-2
2) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.26 Pain Relevance 0.07
Others also reported that herbal medicine could inhibit the growth of MHCC97H cells used in this study [27] and could inhibit the invasiveness potential of HCC cells via MMP2 inhibition [28].
Negative_regulation (inhibition) of MMP2 associated with hepatocellular cancer
3) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.17 Pain Relevance 0.27
However, since loss of MMP-2 produced more subtle phenotypic changes, fibroblast-derived MT1-MMP must have alternate enzymatic targets.
Negative_regulation (loss) of MMP-2 in fibroblast associated with metalloproteinase
4) Confidence 0.44 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1450297 Disease Relevance 0.86 Pain Relevance 0.98
CONCLUSION: The discovery that deficiency of this well-characterized gelatinase/collagenase results in an inherited form of an osteolytic and arthritic disorder provides an invaluable insights for the understanding of osteolysis and arthritis and is the first genetic evidence that MMP2 deficiency is important in growth and development.


Negative_regulation (deficiency) of MMP2
5) Confidence 0.43 Published 2005 Journal Saudi Med J Section Body Doc Link 15756348 Disease Relevance 0 Pain Relevance 0
Inhibitory effect of therapies correlates to the inhibition of MMP2 and VEGF
Negative_regulation (inhibition) of MMP2
6) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.52 Pain Relevance 0
Our data revealed that both tumor MMP2 activity (Figure 4A1) and MMP2 (Figure 4A2) and VEGF (Figure 4C) protein levels were significantly down-regulated in treatment groups, whereas TIMP2 (Figure 4B) levels were up-regulated when compared to the controls.
Negative_regulation (regulated) of MMP2 associated with cancer
7) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.68 Pain Relevance 0
Marimastat efficiently inhibits MMP-2, MMP-3, MMP-7, MMP-9, MMP-13 and TACE activity, with IC50s in the nM range [26], [54].
Negative_regulation (inhibits) of MMP-2
8) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.05 Pain Relevance 0.03
In this study, mice treated with BB-94 as well as mice deficient in Mmp2, Mmp3 or Mmp9 had lower levels of apoptosis and necrosis of hepatocytes, and better survival.
Negative_regulation (deficient) of Mmp2 in hepatocytes associated with necrosis and apoptosis
9) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.82 Pain Relevance 0.09
The first genetic defect of matrix metalloproteinase 2 gene.
Negative_regulation (defect) of metalloproteinase 2 associated with metalloproteinase
10) Confidence 0.38 Published 2005 Journal Saudi Med J Section Title Doc Link 15756348 Disease Relevance 0.76 Pain Relevance 0.14
Treatment of tumor-bearing mice with TGZ decreases the expression and activity of MMP-2 within the tumor, and inhibits primary tumor growth and pulmonary metastasis development.
Negative_regulation (decreases) of MMP-2 associated with cancer and metastasis
11) Confidence 0.38 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2838820 Disease Relevance 1.19 Pain Relevance 0.03
Our data revealed that both tumor MMP2 activity (Figure 4A1) and MMP2 (Figure 4A2) and VEGF (Figure 4C) protein levels were significantly down-regulated in treatment groups, whereas TIMP2 (Figure 4B) levels were up-regulated when compared to the controls.
Negative_regulation (regulated) of MMP2 associated with cancer
12) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.67 Pain Relevance 0
Inhibiting spinal MMP-9 or MMP-2 reduces chronic and/or acute morphine tolerance.
Negative_regulation (Inhibiting) of MMP-2 in spinal associated with tolerance and morphine
13) Confidence 0.34 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519536 Disease Relevance 0.35 Pain Relevance 1.29
Finally, we provide evidence that morphine, when administrated at low, non-toxic concentrations (<10(-9) M) attenuates MMP-2 activity.
Negative_regulation (attenuates) of MMP-2 associated with metalloproteinase and morphine
14) Confidence 0.34 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16386243 Disease Relevance 0.62 Pain Relevance 0.74
Although MMP-2 activity was equivalent in BAL of both strains, MMP-2 activity increased substantially in the lung homogenate of the WT mice.
Negative_regulation (equivalent) of MMP-2 in lung associated with sprains and strains
15) Confidence 0.34 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.25 Pain Relevance 0.11
Moreover borneol could significantly (P < 0.05) decrease MMP-2 activity, and very significantly (P < 0.01) inhibit TIMP-1 production.
Negative_regulation (decrease) of MMP-2
16) Confidence 0.33 Published 2009 Journal J. Oral Pathol. Med. Section Body Doc Link 19267840 Disease Relevance 0.06 Pain Relevance 0
Thus, loss of MT1-MMP consistently decreased the invasion or growth promoting influence of fibroblasts in vivo and in vitro and loss of MMP-2 and MMP-9 altered tumor growth with increasing complexity of the model system.
Negative_regulation (loss) of MMP-2 in fibroblasts associated with cancer and metalloproteinase
17) Confidence 0.32 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1450297 Disease Relevance 0.86 Pain Relevance 0.92
In mouse 3T3 fibroblasts a switch to amoeboid movement was observed upon p53 inactivation [14], while up-regulation of the Rho/ROCK signalling was found in highly metastatic rat sarcoma cells, together with the loss of MMP2 activity and an increased generation of protrusive forces, typical of the amoeboid movement [21].
Negative_regulation (loss) of MMP2 in fibroblasts associated with sarcoma
18) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.66 Pain Relevance 0
Global gene expression profiling of cen3tel cells at different PDs showed a decrease in the expression of different types of extra-cellular matrix proteases during cen3tel propagation in vitro, particularly of several matrix-metalloproteases (MMPs) (Table 1), and zymographic analysis showed a decrease in the activity of MMP2 and MMP9 in tumorigenic cen3tel cells (data not shown), suggesting that increased motility in late cen3tel cells was not strictly dependent on pericellular matrix proteolysis.
Negative_regulation (decrease) of MMP2
19) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.08 Pain Relevance 0
METHODS: Primary mice oral fibroblasts were cultured, the effects of borneol on fibroblasts proliferation, cytotoxicity, collagen production, matrix metalloproteinases-2,9 (MMP-2,9) activities and tissue inhibitors of metalloproteinase 1 (TIMP-1) production were tested by methyl thiazolyl tetrazolium assay, lactic dehydrogenase activity assay, chloramine T method, gelatin zymography and enzyme-linked immunosorbent assay, respectively.
Negative_regulation (inhibitors) of MMP-2 in fibroblasts
20) Confidence 0.29 Published 2009 Journal J. Oral Pathol. Med. Section Body Doc Link 19267840 Disease Relevance 0.09 Pain Relevance 0

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