INT86293

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Context Info
Confidence 0.64
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 11.69
Pain Relevance 3.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp2) extracellular space (Mmp2) extracellular region (Mmp2)
proteinaceous extracellular matrix (Mmp2) plasma membrane (Mmp2) nucleus (Mmp2)
Anatomy Link Frequency
endothelial cells 4
smooth muscle cell 3
fibroblast 2
hippocampus 2
basement membrane 1
Mmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 155 100.00 Very High Very High Very High
rheumatoid arthritis 30 99.84 Very High Very High Very High
Central nervous system 11 99.48 Very High Very High Very High
palliative 44 99.30 Very High Very High Very High
Hippocampus 6 98.92 Very High Very High Very High
Hyperalgesia 9 93.72 High High
Osteoarthritis 1 93.40 High High
cytokine 29 81.64 Quite High
Inflammation 83 81.24 Quite High
Angina 2 77.52 Quite High
Disease Link Frequency Relevance Heat
Cancer 937 100.00 Very High Very High Very High
Rheumatoid Arthritis 34 99.84 Very High Very High Very High
Fibrosis 55 99.64 Very High Very High Very High
Targeted Disruption 26 99.12 Very High Very High Very High
Breast Cancer 62 99.04 Very High Very High Very High
Convulsion 3 98.20 Very High Very High Very High
Metastasis 202 97.84 Very High Very High Very High
Tendinopathy 9 96.84 Very High Very High Very High
Myocardial Infarction 2 96.68 Very High Very High Very High
Neointima 18 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Palliative resection enhances MMP2 activity, elevates tumor protein levels of MMP2 and VEGF, and down-regulates TIMP2 in situ
Positive_regulation (elevates) of Gene_expression (levels) of MMP2 associated with cancer and palliative
1) Confidence 0.64 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 0.60 Pain Relevance 0.59
Overexpression of MMP-2 in tumor tissue has been linked with tumor invasion, metastasis and poor survival in many tumor types including HNSCC [20-22].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of MMP-2 associated with cancer and metastasis
2) Confidence 0.46 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.71 Pain Relevance 0.05
Assay of MMP-2 by gelatin zymography
Positive_regulation (Assay) of Gene_expression (Assay) of MMP-2
3) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 0 Pain Relevance 0
In fibrotic animals, hepatic expression of MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13 mRNA were all significantly upregulated, compared to non-fibrotic controls (Figure 6).
Positive_regulation (upregulated) of Gene_expression (expression) of MMP-2 associated with fibrosis
4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.33 Pain Relevance 0.06
However, only the former maintained high levels of expression of a 90 kD gelatinase up to at least 96 h post ET injection, while in the latter gelatinase expression was down regulated by 24 h.
Positive_regulation (levels) of Gene_expression (expression) of gelatinase
5) Confidence 0.40 Published 2000 Journal Pain Section Abstract Doc Link 10666546 Disease Relevance 0.70 Pain Relevance 0.73
Protein expression of TGF-beta1 and MMP-2 was significantly enhanced in mice treated with morphine.
Positive_regulation (enhanced) of Gene_expression (expression) of MMP-2
6) Confidence 0.25 Published 2010 Journal J Anesth Section Body Doc Link 20127122 Disease Relevance 0.07 Pain Relevance 0
We thus tested whether THL could inhibit VEGF-induced MMP-2 expression in endothelial cells.
Spec (whether) Positive_regulation (-) of Gene_expression (expression) of MMP-2 in endothelial cells associated with metalloproteinase
7) Confidence 0.21 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 0.07 Pain Relevance 0.23
RESULTS: The incidences of MMP-2, -9, and aggrecanase expression in the ID and OA group were significantly higher than those in the normal group (P < .05).
Positive_regulation (incidences) of Gene_expression (expression) of MMP-2
8) Confidence 0.16 Published 2006 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 16831668 Disease Relevance 0.09 Pain Relevance 0
VEGF is known to be able to induce MMP-2 expression in endothelial cells [62].
Positive_regulation (induce) of Gene_expression (expression) of MMP-2 in endothelial cells associated with metalloproteinase
9) Confidence 0.16 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2880989 Disease Relevance 0.12 Pain Relevance 0.23
The expression of the matrix metalloproteinases (MMPs), MMP-9 and MMP-2, have been shown to be increased in various regions of the hippocampus after seizure-induced lesion [21,23,27,28].
Positive_regulation (increased) of Gene_expression (expression) of MMP-2 in hippocampus associated with convulsion, metalloproteinase and hippocampus
10) Confidence 0.13 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1199600 Disease Relevance 0.34 Pain Relevance 0.30
In vivo, MMP-14 (MT1-MMP) and MMP-2 (gelatinase A) are two of several enzymes responsible for the activation of proMMP-13 and both are overexpressed in RA.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of MMP-2 associated with rheumatoid arthritis
11) Confidence 0.11 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.70 Pain Relevance 0.29
Transfections of the breast cancer cell line Hs578T with cDNA for COX-2 led to an increase in expression and activity of matrix metalloproteinase-2, resulting in increasingly invasive behavior of the cells [17].
Positive_regulation (increase) of Gene_expression (expression) of matrix metalloproteinase-2 associated with breast cancer and metalloproteinase
12) Confidence 0.10 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 1.08 Pain Relevance 0.09
This may suggest that MMP-2 is expressed continuously throughout labor [46] while MMP-9 expression is induced by various factors as previously mentioned.
Positive_regulation (induced) of Gene_expression (expressed) of MMP-2
13) Confidence 0.07 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.50 Pain Relevance 0.24
The biochemical changes associated with over-expression of COX-2 include increased expression and activation of metalloproteinase-2 (MMP-2) and reduced expression of E-cadherin [102-104].
Positive_regulation (increased) of Gene_expression (expression) of metalloproteinase-2 associated with metalloproteinase
14) Confidence 0.07 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.93 Pain Relevance 0.09
The biochemical changes associated with over-expression of COX-2 include increased expression and activation of metalloproteinase-2 (MMP-2) and reduced expression of E-cadherin [102-104].
Positive_regulation (activation) of Gene_expression (expression) of metalloproteinase-2 associated with metalloproteinase
15) Confidence 0.07 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.92 Pain Relevance 0.09
The biochemical changes associated with over-expression of COX-2 include increased expression and activation of metalloproteinase-2 (MMP-2) and reduced expression of E-cadherin [102-104].
Positive_regulation (increased) of Gene_expression (expression) of MMP-2 associated with metalloproteinase
16) Confidence 0.07 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.93 Pain Relevance 0.09
The biochemical changes associated with over-expression of COX-2 include increased expression and activation of metalloproteinase-2 (MMP-2) and reduced expression of E-cadherin [102-104].
Positive_regulation (activation) of Gene_expression (expression) of MMP-2 associated with metalloproteinase
17) Confidence 0.07 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 0.92 Pain Relevance 0.09
Expressions of specific genes, shown to be regulated in the cDNA array analysis, were analyzed in the individual samples using real-time PCR. cDNA arrays showed that gene expressions for matrix-metalloproteinase-2 (MMP-2), fibronectin subunit B (FNRB), vascular endothelial growth factor (VEGF), and mitogen-activated protein kinase p38 (MAPKp38) were up-regulated, while matrix-metalloproteinase-3 (MMP-3) and decorin were down-regulated, in tendinosis tissue compared with control tissue.
Positive_regulation (up-regulated) of Gene_expression (expressions) of matrix-metalloproteinase-2 associated with metalloproteinase and tendinopathy
18) Confidence 0.06 Published 2003 Journal J. Orthop. Res. Section Abstract Doc Link 14554207 Disease Relevance 0.67 Pain Relevance 0.40
We demonstrated previously that active extracellular proteolysis is present in the process of arteriogenesis, which includes increased expression of MMP-2 and -9, degradation of the basement membrane and smooth muscle cell migration resulting in neointima formation [2].
Positive_regulation (increased) of Gene_expression (expression) of MMP-2 in smooth muscle cell associated with neointima
19) Confidence 0.05 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0.17 Pain Relevance 0
We demonstrated previously that active extracellular proteolysis is present in the process of arteriogenesis, which includes increased expression of MMP-2 and -9, degradation of the basement membrane and smooth muscle cell migration resulting in neointima formation [2].
Positive_regulation (increased) of in basement membrane Gene_expression (expression) of MMP-2 in smooth muscle cell associated with neointima
20) Confidence 0.02 Published 2008 Journal Mol Cell Biochem Section Body Doc Link PMC2758386 Disease Relevance 0.17 Pain Relevance 0

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