INT86314

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Context Info
Confidence 0.33
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.81
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Cftr) enzyme binding (Cftr) molecular_function (Cftr)
protein complex (Cftr) transmembrane transport (Cftr) cytoplasm (Cftr)
Cftr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 21 99.92 Very High Very High Very High
fibrosis 48 97.00 Very High Very High Very High
Inflammation 31 89.20 High High
cytokine 13 88.16 High High
Prostatitis 68 80.24 Quite High
Inflammatory response 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 23 99.92 Very High Very High Very High
Cystic Fibrosis 48 97.00 Very High Very High Very High
Pulmonary Disease 14 92.72 High High
Disease 19 90.24 High High
INFLAMMATION 33 89.20 High High
Bacterial Infection 23 86.96 High High
Prostatitis 68 80.24 Quite High
Congenital Anomalies 6 56.72 Quite High
Male Infertility 3 38.48 Quite Low
Aspergillus Infection 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 3B and 3C, mRNA and protein expression of CFTR and CAII were significantly up-regulated upon stimulation of E.coli-LPS, respectively.
Regulation (regulated) of Transcription (expression) of CFTR
1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.69 Pain Relevance 0.43
CFTR gene transcription and protein efficiency are influenced by two polymorphic loci, (TG)m and M470V, other than the T5 allele, whose role is already well-established.
Regulation (influenced) of Transcription (transcription) of CFTR gene
2) Confidence 0.31 Published 1999 Journal Clin. Genet. Section Abstract Doc Link 10668931 Disease Relevance 0.39 Pain Relevance 0.35
The molecular basis for the severity of mutations may derive from the extent to which normal mRNA transcription or protein synthesis takes place; for example, splice mutations may influence the efficiency of normal/abnormal CFTR mRNA transcription to varying degrees.
Spec (may) Regulation (influence) of Transcription (transcription) of CFTR
3) Confidence 0.27 Published 2001 Journal Respir Res Section Body Doc Link PMC64805 Disease Relevance 0.72 Pain Relevance 0.06

General Comments

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