INT86315

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Context Info
Confidence 0.53
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.24
Pain Relevance 2.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Cftr) enzyme binding (Cftr) molecular_function (Cftr)
protein complex (Cftr) transmembrane transport (Cftr) cytoplasm (Cftr)
Anatomy Link Frequency
choroid plexus 1
pancreas 1
Cftr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 60 100.00 Very High Very High Very High
Chronic pancreatitis 40 99.92 Very High Very High Very High
cytokine 13 86.00 High High
Inflammation 31 85.92 High High
Prostatitis 68 76.96 Quite High
alcohol 2 38.40 Quite Low
Inflammatory response 3 34.72 Quite Low
Kinase C 2 30.36 Quite Low
agonist 8 28.28 Quite Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystic Fibrosis 60 100.00 Very High Very High Very High
Pancreatitis 42 99.92 Very High Very High Very High
Alcoholic Liver Diseases 6 98.80 Very High Very High Very High
Targeted Disruption 4 91.04 High High
Pulmonary Disease 14 90.96 High High
Disease 22 90.24 High High
INFLAMMATION 34 85.92 High High
Bacterial Infection 23 83.68 Quite High
Pressure And Volume Under Development 4 83.56 Quite High
Prostatitis 68 76.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The molecular basis for the severity of mutations may derive from the extent to which normal mRNA transcription or protein synthesis takes place; for example, splice mutations may influence the efficiency of normal/abnormal CFTR mRNA transcription to varying degrees.
Transcription (transcription) of CFTR
1) Confidence 0.53 Published 2001 Journal Respir Res Section Body Doc Link PMC64805 Disease Relevance 0.72 Pain Relevance 0.06
The expression profiles of trypsinogen, pancreas-specific trypsin inhibitor, cholecystokinin A receptor, cystic fibrosis transmembrane conductance regulator (CFTR), carbonic anhydrase, and Muc1 and Muc4 mucins transcripts were analyzed by RNA slot blot analysis.
Transcription (transcripts) of cystic fibrosis transmembrane conductance regulator in pancreas
2) Confidence 0.52 Published 2006 Journal Pancreas Section Body Doc Link 17079941 Disease Relevance 0 Pain Relevance 0
As shown in Figure 3B and 3C, mRNA and protein expression of CFTR and CAII were significantly up-regulated upon stimulation of E.coli-LPS, respectively.
Transcription (expression) of CFTR
3) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.62 Pain Relevance 0.39
CFTR gene transcription and protein efficiency are influenced by two polymorphic loci, (TG)m and M470V, other than the T5 allele, whose role is already well-established.
Transcription (transcription) of CFTR gene
4) Confidence 0.49 Published 1999 Journal Clin. Genet. Section Abstract Doc Link 10668931 Disease Relevance 0.39 Pain Relevance 0.34
Three mutations of CFTR were detected in four ACP patients with a prevalence (8.9%) not significantly different from that observed (3.0%) in ALD patients and from that expected (3.2%) in our geographical area.
Transcription (detected) of CFTR associated with alcoholic liver diseases and chronic pancreatitis
5) Confidence 0.36 Published 2003 Journal Eur. J. Hum. Genet. Section Abstract Doc Link 12939655 Disease Relevance 1.67 Pain Relevance 1.07
By contrast we were unable to detect mRNA for CFTR in rat choroid plexus.
Neg (unable) Transcription (detect) of CFTR in choroid plexus
6) Confidence 0.27 Published 2007 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2072944 Disease Relevance 0.24 Pain Relevance 0
Determination of the relative contribution of three genes-the cystic fibrosis transmembrane conductance regulator gene, the cationic trypsinogen gene, and the pancreatic secretory trypsin inhibitor gene-to the etiology of idiopathic chronic pancreatitis.
Transcription (contribution) of cystic fibrosis transmembrane conductance regulator associated with fibrosis, cystic fibrosis and chronic pancreatitis
7) Confidence 0.23 Published 2002 Journal Eur. J. Hum. Genet. Section Title Doc Link 11938439 Disease Relevance 0.60 Pain Relevance 0.43

General Comments

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