INT8632

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Context Info
Confidence 0.54
First Reported 1992
Last Reported 2010
Negated 3
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 2.87
Pain Relevance 9.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Nfasc) plasma membrane (Nfasc)
Anatomy Link Frequency
dopaminergic neurons 3
substantia nigra 2
blood 1
grey matter 1
spines 1
Nfasc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 16 99.80 Very High Very High Very High
Substantia nigra 8 99.68 Very High Very High Very High
Nicotine 34 99.62 Very High Very High Very High
substance P 54 99.52 Very High Very High Very High
cocaine 37 98.98 Very High Very High Very High
Morphine 34 98.74 Very High Very High Very High
Ventral tegmentum 57 98.56 Very High Very High Very High
Spinal cord 15 97.72 Very High Very High Very High
Dorsal horn 42 95.40 Very High Very High Very High
Inflammation 7 93.20 High High
Disease Link Frequency Relevance Heat
Skin Infection 23 100.00 Very High Very High Very High
Appetite Loss 6 99.50 Very High Very High Very High
Stress 3 97.08 Very High Very High Very High
Anorexia 1 96.16 Very High Very High Very High
Burns 17 91.52 High High
Injury 37 91.12 High High
Wound Healing 21 90.08 High High
Sprains And Strains 4 82.64 Quite High
Bacterial Respiratory Disease 5 81.32 Quite High
Flushing 4 73.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such regulation of NF proteins was selective, in that no detectable changes were observed in the levels of eight other major cytoskeletal or cytoskeletal-associated proteins analyzed.
Regulation (regulation) of NF
1) Confidence 0.54 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.07 Pain Relevance 1.09
Morphine and cocaine regulation of NFs showed regional specificity, as NF levels were not altered in the substantia nigra, or other parts of the brain or spinal cord, by these drug treatments.
Neg (not) Regulation (altered) of NF in spinal cord associated with substantia nigra, spinal cord, cocaine and morphine
2) Confidence 0.54 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.10 Pain Relevance 1.08
Ultrastructural analysis was applied to evaluate changes in NF-68, NF-160 and NF-200 immunoreactivity in regions of the VTA that contain dopaminergic neurons following chronic nicotine treatment.
Regulation (changes) of NF-200 in dopaminergic neurons associated with ventral tegmentum and nicotine
3) Confidence 0.42 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12372024 Disease Relevance 0 Pain Relevance 0.63
Ultrastructural analysis was applied to evaluate changes in NF-68, NF-160 and NF-200 immunoreactivity in regions of the VTA that contain dopaminergic neurons following chronic nicotine treatment.
Regulation (changes) of NF-68 in dopaminergic neurons associated with ventral tegmentum and nicotine
4) Confidence 0.42 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12372024 Disease Relevance 0 Pain Relevance 0.63
Ultrastructural analysis was applied to evaluate changes in NF-68, NF-160 and NF-200 immunoreactivity in regions of the VTA that contain dopaminergic neurons following chronic nicotine treatment.
Regulation (changes) of NF-160 in dopaminergic neurons associated with ventral tegmentum and nicotine
5) Confidence 0.42 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12372024 Disease Relevance 0 Pain Relevance 0.63
Chronic nicotine treatment reduced NF-160 and NF-200 immunoreactivity by 44.5% (P<0.01) and 22.5% (P<0. 05), respectively, in the ventral tegmental area but not in the substantia nigra.
Regulation (immunoreactivity) of NF-160 in substantia nigra associated with ventral tegmentum, substantia nigra and nicotine
6) Confidence 0.27 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10771021 Disease Relevance 0 Pain Relevance 0.75
Chronic nicotine treatment reduced NF-160 and NF-200 immunoreactivity by 44.5% (P<0.01) and 22.5% (P<0. 05), respectively, in the ventral tegmental area but not in the substantia nigra.
Regulation (immunoreactivity) of NF-200 in substantia nigra associated with ventral tegmentum, substantia nigra and nicotine
7) Confidence 0.27 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10771021 Disease Relevance 0 Pain Relevance 0.75
In contrast, the anorectic effects of either dF or dNF were unchanged in PCPA-treated rats relative to controls.
Neg (unchanged) Regulation (unchanged) of dNF associated with appetite loss
8) Confidence 0.27 Published 2000 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 10666140 Disease Relevance 0.52 Pain Relevance 0.29
Simultaneous dialysis in brain and blood allowed evaluation of the differential effects of dNF and FLU on 5-HT and 5-HIAA in the two places.
Regulation (effects) of dNF in brain associated with fluoxetine
9) Confidence 0.27 Published 1996 Journal Life Sci. Section Abstract Doc Link 8614274 Disease Relevance 0 Pain Relevance 0.72
However, no significant difference was observed in the mean values of NF-11 (27.0 ± 1.7) and silver sulfadiazine 1% cream, USP (25.9 ± 1.3).
Regulation (values) of NF-11
10) Confidence 0.24 Published 2010 Journal Eplasty Section Body Doc Link PMC2890388 Disease Relevance 1.19 Pain Relevance 0.09
Furthermore, NF levels were not altered by chronic treatment with either imipramine or haloperidol, two psychotropic drugs without reinforcing properties, or by chronic stress.
Neg (not) Regulation (altered) of NF associated with stress
11) Confidence 0.21 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.09 Pain Relevance 1.13
Simultaneous dialysis in brain and blood allowed evaluation of the differential effects of dNF and FLU on 5-HT and 5-HIAA in the two places.
Regulation (effects) of dNF in blood associated with fluoxetine
12) Confidence 0.09 Published 1996 Journal Life Sci. Section Abstract Doc Link 8614274 Disease Relevance 0 Pain Relevance 0.72
However, aggressive early surgery is the single most important influence on the survival rates of patients affected with NF.
Regulation (affected) of NF associated with skin infection
13) Confidence 0.09 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2442594 Disease Relevance 0.89 Pain Relevance 0.12
NF200 immunoreactivity was not seen in dendritic spines.
Regulation (immunoreactivity) of NF200 in spines
14) Confidence 0.00 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2635481 Disease Relevance 0 Pain Relevance 0.19
NF200 immunoreactivity was present throughout both the white and grey matter of the spinal cord.
Regulation (immunoreactivity) of NF200 in grey matter associated with spinal cord
15) Confidence 0.00 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2635481 Disease Relevance 0 Pain Relevance 0.26

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