INT8633

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Context Info
Confidence 0.51
First Reported 1992
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 8
Disease Relevance 0.60
Pain Relevance 8.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Nfasc) plasma membrane (Nfasc)
Anatomy Link Frequency
brain 2
Nfasc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 72 99.72 Very High Very High Very High
Ventral tegmentum 48 99.68 Very High Very High Very High
Morphine 64 99.50 Very High Very High Very High
Spinal cord 8 94.20 High High
Substantia nigra 8 92.44 High High
addiction 8 89.68 High High
Dopamine 8 75.00 Quite High
Catecholamine 8 74.64 Quite High
opiate 8 66.84 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 8 90.00 High High
Stress 8 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic, but not acute, administration of either morphine or cocaine was found to decrease levels of the three NF proteins, NF-200 (NF-H), NF-160 (NF-M), and NF-68 (NF-L), by between 15% and 50% in the VTA by back phosphorylation, immunolabeling, and Coomassie blue staining.
Negative_regulation (decrease) of Gene_expression (levels) of NF associated with ventral tegmentum, cocaine and morphine
1) Confidence 0.51 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.06 Pain Relevance 1.12
Thus, decreased NF levels in the VTA in response to chronic morphine and chronic cocaine could lead to drug-induced alterations in the structural and functional properties of this brain region, which may represent, in turn, part of a common biochemical basis of morphine and cocaine addiction and craving.
Negative_regulation (decreased) of Gene_expression (levels) of NF in brain associated with addiction, ventral tegmentum, cocaine and morphine
2) Confidence 0.51 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.18 Pain Relevance 1.01
Chronic, but not acute, administration of either morphine or cocaine was found to decrease levels of the three NF proteins, NF-200 (NF-H), NF-160 (NF-M), and NF-68 (NF-L), by between 15% and 50% in the VTA by back phosphorylation, immunolabeling, and Coomassie blue staining.
Negative_regulation (decrease) of Gene_expression (levels) of NF associated with ventral tegmentum, cocaine and morphine
3) Confidence 0.37 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.06 Pain Relevance 1.08
Chronic, but not acute, administration of either morphine or cocaine was found to decrease levels of the three NF proteins, NF-200 (NF-H), NF-160 (NF-M), and NF-68 (NF-L), by between 15% and 50% in the VTA by back phosphorylation, immunolabeling, and Coomassie blue staining.
Negative_regulation (decrease) of Gene_expression (levels) of NF associated with ventral tegmentum, cocaine and morphine
4) Confidence 0.37 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.06 Pain Relevance 1.11
Chronic, but not acute, administration of either morphine or cocaine was found to decrease levels of the three NF proteins, NF-200 (NF-H), NF-160 (NF-M), and NF-68 (NF-L), by between 15% and 50% in the VTA by back phosphorylation, immunolabeling, and Coomassie blue staining.
Negative_regulation (decrease) of Gene_expression (levels) of NF associated with ventral tegmentum, cocaine and morphine
5) Confidence 0.37 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.06 Pain Relevance 1.11
Chronic, but not acute, administration of either morphine or cocaine was found to decrease levels of the three NF proteins, NF-200 (NF-H), NF-160 (NF-M), and NF-68 (NF-L), by between 15% and 50% in the VTA by back phosphorylation, immunolabeling, and Coomassie blue staining.
Negative_regulation (decrease) of Gene_expression (levels) of NF associated with ventral tegmentum, cocaine and morphine
6) Confidence 0.37 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.06 Pain Relevance 1.11
Chronic, but not acute, administration of either morphine or cocaine was found to decrease levels of the three NF proteins, NF-200 (NF-H), NF-160 (NF-M), and NF-68 (NF-L), by between 15% and 50% in the VTA by back phosphorylation, immunolabeling, and Coomassie blue staining.
Negative_regulation (decrease) of Gene_expression (levels) of NF associated with ventral tegmentum, cocaine and morphine
7) Confidence 0.37 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.06 Pain Relevance 1.14
Chronic, but not acute, administration of either morphine or cocaine was found to decrease levels of the three NF proteins, NF-200 (NF-H), NF-160 (NF-M), and NF-68 (NF-L), by between 15% and 50% in the VTA by back phosphorylation, immunolabeling, and Coomassie blue staining.
Negative_regulation (decrease) of Gene_expression (levels) of NF associated with ventral tegmentum, cocaine and morphine
8) Confidence 0.37 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.06 Pain Relevance 1.11

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