INT8634

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Context Info
Confidence 0.68
First Reported 1992
Last Reported 2011
Negated 2
Speculated 1
Reported most in Abstract
Documents 23
Total Number 24
Disease Relevance 9.16
Pain Relevance 14.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Nfasc) plasma membrane (Nfasc)
Anatomy Link Frequency
brain 2
facial nerve 2
neurons 2
dendrites 1
sensory neurons 1
Nfasc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 68 99.82 Very High Very High Very High
Ventral tegmentum 48 99.68 Very High Very High Very High
cocaine 72 99.54 Very High Very High Very High
Neuropeptide 6 99.54 Very High Very High Very High
carpal tunnel syndrome 18 99.40 Very High Very High Very High
Morphine 64 99.32 Very High Very High Very High
spastic colon 4 98.96 Very High Very High Very High
opioid receptor 10 97.76 Very High Very High Very High
unmyelinated 10 95.04 Very High Very High Very High
Calcium channel 2 94.80 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 71 99.82 Very High Very High Very High
Carpal Tunnel Syndrome 18 99.40 Very High Very High Very High
Nervous System Injury 17 99.16 Very High Very High Very High
Functional Bowel Disorder 2 98.96 Very High Very High Very High
Infection 10 98.64 Very High Very High Very High
Herpes Zoster 22 98.44 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 97.92 Very High Very High Very High
Facial Nerve Injuries 18 96.68 Very High Very High Very High
Pain 45 91.60 High High
Drug Dependence 8 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic, but not acute, administration of either morphine or cocaine was found to decrease levels of the three NF proteins, NF-200 (NF-H), NF-160 (NF-M), and NF-68 (NF-L), by between 15% and 50% in the VTA by back phosphorylation, immunolabeling, and Coomassie blue staining.
Gene_expression (levels) of NF associated with ventral tegmentum, cocaine and morphine
1) Confidence 0.68 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.06 Pain Relevance 1.11
Thus, decreased NF levels in the VTA in response to chronic morphine and chronic cocaine could lead to drug-induced alterations in the structural and functional properties of this brain region, which may represent, in turn, part of a common biochemical basis of morphine and cocaine addiction and craving.
Gene_expression (levels) of NF in brain associated with addiction, ventral tegmentum, cocaine and morphine
2) Confidence 0.68 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.18 Pain Relevance 1.01
Chronic, but not acute, administration of either morphine or cocaine was found to decrease levels of the three NF proteins, NF-200 (NF-H), NF-160 (NF-M), and NF-68 (NF-L), by between 15% and 50% in the VTA by back phosphorylation, immunolabeling, and Coomassie blue staining.
Gene_expression (levels) of NF associated with ventral tegmentum, cocaine and morphine
3) Confidence 0.59 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.06 Pain Relevance 1.08
Chronic, but not acute, administration of either morphine or cocaine was found to decrease levels of the three NF proteins, NF-200 (NF-H), NF-160 (NF-M), and NF-68 (NF-L), by between 15% and 50% in the VTA by back phosphorylation, immunolabeling, and Coomassie blue staining.
Gene_expression (levels) of NF associated with ventral tegmentum, cocaine and morphine
4) Confidence 0.59 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.06 Pain Relevance 1.11
Chronic, but not acute, administration of either morphine or cocaine was found to decrease levels of the three NF proteins, NF-200 (NF-H), NF-160 (NF-M), and NF-68 (NF-L), by between 15% and 50% in the VTA by back phosphorylation, immunolabeling, and Coomassie blue staining.
Gene_expression (levels) of NF associated with ventral tegmentum, cocaine and morphine
5) Confidence 0.59 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.06 Pain Relevance 1.14
Chronic, but not acute, administration of either morphine or cocaine was found to decrease levels of the three NF proteins, NF-200 (NF-H), NF-160 (NF-M), and NF-68 (NF-L), by between 15% and 50% in the VTA by back phosphorylation, immunolabeling, and Coomassie blue staining.
Gene_expression (levels) of NF associated with ventral tegmentum, cocaine and morphine
6) Confidence 0.59 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.06 Pain Relevance 1.11
Chronic, but not acute, administration of either morphine or cocaine was found to decrease levels of the three NF proteins, NF-200 (NF-H), NF-160 (NF-M), and NF-68 (NF-L), by between 15% and 50% in the VTA by back phosphorylation, immunolabeling, and Coomassie blue staining.
Gene_expression (levels) of NF associated with ventral tegmentum, cocaine and morphine
7) Confidence 0.59 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.06 Pain Relevance 1.11
Chronic, but not acute, administration of either morphine or cocaine was found to decrease levels of the three NF proteins, NF-200 (NF-H), NF-160 (NF-M), and NF-68 (NF-L), by between 15% and 50% in the VTA by back phosphorylation, immunolabeling, and Coomassie blue staining.
Gene_expression (levels) of NF associated with ventral tegmentum, cocaine and morphine
8) Confidence 0.59 Published 1992 Journal J. Neurosci. Section Abstract Doc Link 1376774 Disease Relevance 0.06 Pain Relevance 1.11
In controls, equianorectic doses of dF and dNF induced Fos-ir in similar brain regions, but dNF produced relatively larger effects than dF in SON, PVN, and MnPO.
Gene_expression (produced) of dNF in MnPO
9) Confidence 0.46 Published 2000 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 10666140 Disease Relevance 0.34 Pain Relevance 0.20
Tetzlaff and co-workers [42,43] have demonstrated increased syntheses of the cytoskeletal proteins actin and tubulin after axotomy of the rat facial nerve simultaneously to the enhanced NF contents and a low regulation of NF synthesis.
Gene_expression (synthesis) of NF in facial nerve
10) Confidence 0.19 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.07 Pain Relevance 0.03
Nerve injuries did not promote changes in the number of NF+CV neurons of the lesioned side of the seven day-axotomized facial nuclei compared to sham rats (1 ± 0.04, 0.91 ± 0.052, 1.08 ± 0.06 of the control, crushed and transected rats, respectively, Figure 1D).
Gene_expression (neurons) of NF in neurons associated with nervous system injury
11) Confidence 0.14 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.15 Pain Relevance 0
The NF+CV neuronal profiles, GFAP+CV astroglial profiles and the glial FGF-2 immunoreactive profiles from the facial nerve injury experiment were counted under camera lucida microscopy at 16× magnification mounted in a Zeiss microscope (Germany).
Gene_expression (profiles) of NF in facial nerve associated with facial nerve injuries
12) Confidence 0.14 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.10 Pain Relevance 0
Region-specific increases in brain levels of APP, neurofilament-70 (NF-70), and platelet-activating factor receptor (PAF-R) were found in EC rats.
Gene_expression (levels) of NF-70 in brain
13) Confidence 0.09 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12492435 Disease Relevance 0.37 Pain Relevance 0.21
The expressions of eNOS, NF-??
Gene_expression (expressions) of NF
14) Confidence 0.05 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 20872582 Disease Relevance 1.00 Pain Relevance 0.74
Analysis included histological and immunohistochemical examination for the distribution of endothelial nitric oxide synthase (eNOS), nuclear factor (NF)-??
Gene_expression (distribution) of NF
15) Confidence 0.04 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 20872582 Disease Relevance 1.07 Pain Relevance 0.70
There was increased expression of neuropeptide Y (NPY) in neurons co-expressing NF-200.
Gene_expression (expressing) of NF-200 in neurons associated with neuropeptide
16) Confidence 0.04 Published 2005 Journal Pain Section Abstract Doc Link 16213091 Disease Relevance 1.73 Pain Relevance 0.97
Cryosections of excised DRGs were stained for macrophages (ED1 marker) and T cells (T-cell receptor marker) [15], and for damaged neurons expressing activating transcription factor 3 (ATF3) in subpopulations of medium- to large-sized DRG neurons expressing neurofilament-200 (NF-200) [16] and small-sized DRG neurons expressing peripherin, a marker found predominantly in small sensory ganglion cells with unmyelinated C-fiber axons [17].
Gene_expression (expressing) of NF-200 in T-cell associated with ganglion cysts, c fibre, dorsal root ganglion and unmyelinated
17) Confidence 0.03 Published 2011 Journal Mol Pain Section Body Doc Link PMC3022745 Disease Relevance 0.59 Pain Relevance 0.56
Immunohistochemical analysis of DRG following VZV infection showed the presence of a viral immediate early gene protein (IE62) co-expressed with markers of A- (neurofilament-200; NF-200) and C- (peripherin) afferent sensory neurons.
Gene_expression (co-expressed) of NF-200 in sensory neurons associated with herpes zoster and infection
18) Confidence 0.03 Published 2005 Journal Pain Section Abstract Doc Link 16213091 Disease Relevance 1.78 Pain Relevance 0.86
The ChAT(+) fibres did not express NF.
Neg (not) Gene_expression (express) of NF
19) Confidence 0.03 Published 2006 Journal Cell Tissue Res. Section Abstract Doc Link 16525831 Disease Relevance 0.16 Pain Relevance 0.26
Double-labeling analysis with NF-200 and CysLT2 showed that most CysLT2-labeled cells did not express NF-200.
Neg (not) Gene_expression (express) of NF-200
20) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949724 Disease Relevance 0.68 Pain Relevance 0.44

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