INT86349

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Context Info
Confidence 0.42
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.80
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

response to stress (Tacr1, Fos) aging (Fos) nucleolus (Fos)
nucleus (Fos) plasma membrane (Tacr1) DNA binding (Fos)
Anatomy Link Frequency
brain 3
Tacr1 (Rattus norvegicus)
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 10 100.00 Very High Very High Very High
antagonist 14 91.96 High High
medulla 1 77.08 Quite High
Intracerebroventricular 4 65.64 Quite High
Neurotransmitter 2 52.00 Quite High
parabrachial 1 49.04 Quite Low
Thalamus 1 48.48 Quite Low
Central grey 1 27.80 Quite Low
Locus ceruleus 1 26.68 Quite Low
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 7 100.00 Very High Very High Very High
Nociception 2 97.68 Very High Very High Very High
Stress 2 94.64 High High
Hypertension 1 83.28 Quite High
Urological Neuroanatomy 1 27.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results demonstrate that blockade of brain tachykinin receptors, especially of the neurokinin-1 receptor, reduces the behavioural response to pain and the pain-induced c-Fos activation in distinct brain areas which are intimately linked with nociceptive neurotransmission and the initiation and integration of central stress responses.
Negative_regulation (blockade) of neurokinin-1 receptor in brain Negative_regulation (reduces) of Positive_regulation (activation) of c-Fos in brain associated with stress, nociception and pain
1) Confidence 0.42 Published 2000 Journal Neuroscience Section Abstract Doc Link 10670449 Disease Relevance 0.80 Pain Relevance 0.92

General Comments

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