INT86361

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Context Info
Confidence 0.53
First Reported 1999
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 39
Total Number 40
Disease Relevance 18.93
Pain Relevance 10.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
nerve 8
endothelial cells 5
brain 4
TMJ 4
jejunum 3
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 345 100.00 Very High Very High Very High
cytokine 235 100.00 Very High Very High Very High
orphanin 13 99.74 Very High Very High Very High
endometriosis 42 99.56 Very High Very High Very High
Inflammatory stimuli 3 99.56 Very High Very High Very High
Morphine 13 99.48 Very High Very High Very High
Neuronal nitric oxide synthase 2 99.32 Very High Very High Very High
Dorsal horn 32 99.08 Very High Very High Very High
bradykinin 10 98.54 Very High Very High Very High
Spinal cord 34 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 404 100.00 Very High Very High Very High
Neurodegenerative Disease 28 100.00 Very High Very High Very High
Sepsis 129 99.76 Very High Very High Very High
Endometriosis (extended) 48 99.56 Very High Very High Very High
Disease 196 99.12 Very High Very High Very High
Adult Respiratory Distress Syndrome 30 98.42 Very High Very High Very High
Parkinson's Disease 61 98.00 Very High Very High Very High
Fever 5 97.76 Very High Very High Very High
Pain 111 97.72 Very High Very High Very High
Toxicity 10 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inducible NOS isoform is elevated in tissues of patients with endometriosis [131].
Positive_regulation (elevated) of Positive_regulation (Inducible) of NOS associated with endometriosis
1) Confidence 0.53 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 1.24 Pain Relevance 0.64
NOS phosphorylation in some other brain regions, which may be regulated by PKA, probably contributes to the increase of NOS activity in morphine-dependent mice.
Positive_regulation (contributes) of Positive_regulation (increase) of NOS in brain associated with morphine
2) Confidence 0.51 Published 1999 Journal Sheng Li Xue Bao Section Abstract Doc Link 11499006 Disease Relevance 0.15 Pain Relevance 1.10
This, in turn, triggers the rapid and dynamic activation of Ca2+/calmodulin-sensitive NO synthases (NOS), such as through Ser1177 phosphorylation and activation of eNOS, promoting the synthesis of NO from l-Arg.
Positive_regulation (triggers) of Positive_regulation (activation) of NOS
3) Confidence 0.43 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.14
The upregulation of penile NOS activity may be achieved by: a) increase in NOS substrate concentration, b) stimulation of NOS activity through related pathways or c) blockade of endogenous NOS inhibitors.
Positive_regulation (increase) of Positive_regulation (stimulation) of NOS
4) Confidence 0.40 Published 2000 Journal Drugs Today Section Abstract Doc Link 12879114 Disease Relevance 0.71 Pain Relevance 0.13
Formation of NO could also occur after receptor stimulated activation of constitutive NOS (cNOS) or activation of neuronal NOS (nNOS) in nerve endings.
Positive_regulation (stimulated) of Positive_regulation (activation) of constitutive NOS in nerve
5) Confidence 0.34 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693561 Disease Relevance 0.50 Pain Relevance 0.29
We have recently reported the upregulation of kinin B1 and B2 receptors at the same pain model and time frame [34], both of which cause elevated free intracellular calcium upon activation [35] that may contribute to the activation of both NOS isoforms.
Positive_regulation (contribute) of Positive_regulation (activation) of NOS associated with pain
6) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949722 Disease Relevance 0.59 Pain Relevance 0.80
Formation of NO could also occur after receptor stimulated activation of constitutive NOS (cNOS) or activation of neuronal NOS (nNOS) in nerve endings.
Positive_regulation (activation) of Positive_regulation (activation) of nNOS in nerve
7) Confidence 0.25 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693561 Disease Relevance 0.50 Pain Relevance 0.29
Formation of NO could also occur after receptor stimulated activation of constitutive NOS (cNOS) or activation of neuronal NOS (nNOS) in nerve endings.
Positive_regulation (activation) of Positive_regulation (activation) of neuronal NOS in nerve
8) Confidence 0.25 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693561 Disease Relevance 0.50 Pain Relevance 0.29
Formation of NO could also occur after receptor stimulated activation of constitutive NOS (cNOS) or activation of neuronal NOS (nNOS) in nerve endings.
Positive_regulation (activation) of Positive_regulation (activation) of constitutive NOS in nerve
9) Confidence 0.23 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693561 Disease Relevance 0.50 Pain Relevance 0.29
This peptide acts with b2 receptors on the EC cell surface membrane, increasing the generation of NO via NOS activation.
Positive_regulation (increasing) of Neg (NO) Positive_regulation (activation) of NOS
10) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 0.40 Pain Relevance 0.14
, as well as nitric oxide production secondary to the induction of inducible nitric oxide synthase [29,30].
Positive_regulation (induction) of Positive_regulation (inducible) of nitric oxide synthase
11) Confidence 0.22 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1276811 Disease Relevance 0.60 Pain Relevance 0.38
RESULTS: Exposure of TMJ fibrochondrocytes to rHuIL-1beta resulted in the induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2), which were paralleled by NO and PGE2 production.
Positive_regulation (resulted) of Positive_regulation (induction) of nitric oxide synthase in TMJ
12) Confidence 0.21 Published 2001 Journal Arthritis Rheum. Section Body Doc Link 11263775 Disease Relevance 0 Pain Relevance 0
One study found increased constitutive nitric oxide synthase in the airway epithelium and increased inducible nitric oxide synthase in macrophages of mice exposed to diesel exhaust particles compared with control mice (Lim et al. 1998).
Positive_regulation (increased) of Positive_regulation (inducible) of nitric oxide synthase in epithelium
13) Confidence 0.20 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852653 Disease Relevance 0.87 Pain Relevance 0.26
An alternative explanation for the bilateral expression of NOS isoforms in monoarthritic rats could be that the process of disease spreads to the contralateral side, thereby stimulating the upregulation of certain molecules (namely NOS) in the contralateral dorsal horn.
Positive_regulation (stimulating) of Positive_regulation (upregulation) of NOS in dorsal horn associated with dorsal horn and disease
14) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206346 Disease Relevance 0.67 Pain Relevance 0.46
RESULTS: Exposure of TMJ fibrochondrocytes to rHuIL-1beta resulted in the induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2), which were paralleled by NO and PGE2 production.
Positive_regulation (resulted) of Positive_regulation (induction) of nitric oxide synthase in TMJ
15) Confidence 0.15 Published 2001 Journal Arthritis Rheum. Section Body Doc Link 11263775 Disease Relevance 0 Pain Relevance 0
NOS is regulated by bradykinin, which acts with b2 receptors on the endothelial cell surface membrane, increasing the production of NO via NOS activation.
Positive_regulation (increasing) of Positive_regulation (activation) of NOS in endothelial cell associated with bradykinin
16) Confidence 0.14 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.42 Pain Relevance 0.17
Sympathetic nerve activation during sepsis appears to depend on the induction of NOS and COX; the COX pathway is involved in the elevation of temperature and in the activation of sympathetic nerve activity but not in the hypotension.
Spec (appears) Positive_regulation (depend) of Positive_regulation (induction) of NOS in Sympathetic associated with hypotension and sepsis
17) Confidence 0.14 Published 2002 Journal Auton Neurosci Section Abstract Doc Link 12144036 Disease Relevance 0.95 Pain Relevance 0.20
The mitochondrial adaptive response of mtNOS in neurodegenerative diseases is speculated as an increased mtNOS activity that supports an increased mitochondrial biogenesis in order to provide an increased energy supply.
Positive_regulation (increased) of Positive_regulation (response) of mtNOS associated with neurodegenerative disease
18) Confidence 0.13 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2947925 Disease Relevance 0.69 Pain Relevance 0.03
The available evidence indicates that increased mitochondrial matrix NO levels, secondary to mtNOS over-expression or activation or to NO diffusion from cytosolic NOS, leads to ONOO?
Neg (NO) Positive_regulation (increased) of Positive_regulation (activation) of mtNOS
19) Confidence 0.13 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2947925 Disease Relevance 0.08 Pain Relevance 0
Besides, increased phosphoinositide (PI) turnover and stimulation of nitric oxide synthase (NOS) and cyclic GMP (cGMP) production.
Positive_regulation (increased) of Positive_regulation (stimulation) of nitric oxide synthase
20) Confidence 0.10 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15814109 Disease Relevance 0.09 Pain Relevance 0.06

General Comments

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