INT86368

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Context Info
Confidence 0.50
First Reported 1999
Last Reported 2011
Negated 3
Speculated 2
Reported most in Body
Documents 31
Total Number 34
Disease Relevance 16.36
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome (TEP1) RNA binding (TEP1) nucleus (TEP1)
cytoplasm (TEP1)
Anatomy Link Frequency
somatic cells 4
liver 2
telomere 2
stem cell 2
nodules 1
TEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 7 96.72 Very High Very High Very High
Inflammation 354 93.52 High High
Kinase C 611 92.60 High High
cytokine 177 86.80 High High
imagery 18 64.92 Quite High
Catecholamine 9 59.88 Quite High
Pain 16 49.20 Quite Low
COX2 1 48.48 Quite Low
cINOD 20 47.20 Quite Low
Central nervous system 14 31.96 Quite Low
Disease Link Frequency Relevance Heat
Repression 52 99.72 Very High Very High Very High
Chronic Hepatitis 21 99.72 Very High Very High Very High
Immunotherapy Of Cancer 10 99.44 Very High Very High Very High
Syndrome 3 98.96 Very High Very High Very High
Cancer 703 98.72 Very High Very High Very High
Microsatellite Instability 1 98.68 Very High Very High Very High
Sprains And Strains 15 98.52 Very High Very High Very High
Osteoporosis 8 98.08 Very High Very High Very High
Congenital Anomalies 4 96.32 Very High Very High Very High
Capsule Opacification 135 96.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This method constitutes an alternative and well accepted approach to investigate telomerase expression in tissue samples.
Spec (investigate) Gene_expression (expression) of telomerase
1) Confidence 0.50 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.52 Pain Relevance 0.03
However, certain highly proliferative human cell types, such as cells in the regenerative basal layer of epidermis [13] and B lymphocytes in the germinal center [14-16], transiently express high levels of telomerase activity upon commitment to clonal expansion.
Gene_expression (express) of telomerase in B lymphocytes
2) Confidence 0.50 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.36 Pain Relevance 0
Quantification of telomerase activity
Gene_expression (activity) of telomerase
3) Confidence 0.43 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.19 Pain Relevance 0.05
Together, these publications further support our data and suggest a molecular link between telomerase activation and growth factors as well as signal transduction pathways driving liver regeneration.
Gene_expression (activation) of telomerase in liver
4) Confidence 0.43 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.06 Pain Relevance 0
For example, in marked contrast to humans, commonly employed inbred laboratory mouse strains have approximately ten times longer telomeres (up to 150 kilo bases) and express robust levels of telomerase activity in a wide range of somatic tissues, including normal liver [18].
Gene_expression (express) of telomerase in liver associated with sprains and strains
5) Confidence 0.39 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.29 Pain Relevance 0
Our data demonstrating telomerase activation in regenerating pig liver tissue are consistent with previous findings in patients with chronic hepatitis showing TERT expression and telomerase activation in regenerative nodules [30,31].
Gene_expression (expression) of telomerase in nodules associated with chronic hepatitis
6) Confidence 0.39 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.24 Pain Relevance 0
In addition, telomerase activity levels, expressed as total product generated (TPG) per ?
Gene_expression (expressed) of telomerase
7) Confidence 0.39 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.06 Pain Relevance 0
Several other protein subunits associate with these core components to form the telomerase holoenzyme that synthesizes telomeric DNA [7].
Gene_expression (synthesizes) of telomerase holoenzyme
8) Confidence 0.10 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.25 Pain Relevance 0
Telomere attrition even in the presence of telomerase suggests that the level of hTERT and telomerase expression is insufficient for the maintenance of telomere lengths.
Gene_expression (expression) of telomerase in telomere
9) Confidence 0.10 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.48 Pain Relevance 0.05
While the expression of hTERT is repressed in normal somatic cells (telomerase negative) and is upregulated in immortal cells (telomerase positive), the other components of telomerase holoenzyme are usually expressed ubiquitously in both telomerase positive and telomerase negative cells [7].
Neg (negative) Gene_expression (expressed) of telomerase holoenzyme in somatic cells
10) Confidence 0.10 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.20 Pain Relevance 0
The Receptor Ck dependent down-regulation of hTERT transcription observed in normal human PBMCs may reflect a general mechanism for the repression of hTERT and telomerase expression in normal somatic cells.
Gene_expression (expression) of telomerase in somatic cells associated with repression
11) Confidence 0.10 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.18 Pain Relevance 0.17
Telomerase is also expressed in germ line cells and in a small number of normal somatic cells that possess high turnover capability, such as, haematopoietic stem cells, peripheral blood lymphocytes, skin keratinocytes, intestinal crypt cells etc. [4].
Gene_expression (expressed) of Telomerase in germ line cells
12) Confidence 0.10 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.13 Pain Relevance 0
This deficient expression of hTERT and telomerase in PBMCs possibly represents a tumor suppressor mechanism, essential for the protection of these cells against the development of cancer.
Gene_expression (expression) of telomerase associated with cancer
13) Confidence 0.09 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.49 Pain Relevance 0
The hTERT transcripts are expressed in these cells independently of the presence, absence or quantitative level of detectable telomerase activity [47].
Gene_expression (expressed) of telomerase
14) Confidence 0.09 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.27 Pain Relevance 0
While the expression of hTERT is repressed in normal somatic cells (telomerase negative) and is upregulated in immortal cells (telomerase positive), the other components of telomerase holoenzyme are usually expressed ubiquitously in both telomerase positive and telomerase negative cells [7].
Neg (negative) Gene_expression (positive) of telomerase in somatic cells
15) Confidence 0.09 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.19 Pain Relevance 0
Further, it has been reported that unlike most telomerase positive cells, peripheral blood lymphocytes do not exhibit a tight correlation between hTERT mRNA expression and telomerase activity.
Gene_expression (expression) of telomerase in lymphocytes
16) Confidence 0.09 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.33 Pain Relevance 0
Despite the presence of telomerase, the telomeres in these cells shorten progressively with increasing age and with cellular replication in vitro [45,46].
Gene_expression (presence) of telomerase in telomeres
17) Confidence 0.08 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.48 Pain Relevance 0.09
Hence, the cellular models employed in the present study were the normal human peripheral blood mononuclear cells (PBMCs), which are known to express hTERT and telomerase in a highly regulated manner.
Gene_expression (express) of telomerase in mononuclear cells
18) Confidence 0.08 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.40 Pain Relevance 0
Telomerase is a RNA-dependent DNA polymerase that synthesizes telomeric DNA sequences and almost universally provides the molecular basis for unlimited proliferative potential.
Gene_expression (synthesizes) of Telomerase
19) Confidence 0.08 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.09 Pain Relevance 0
While the expression of hTERT is repressed in normal somatic cells (telomerase negative) and is upregulated in immortal cells (telomerase positive), the other components of telomerase holoenzyme are usually expressed ubiquitously in both telomerase positive and telomerase negative cells [7].
Neg (negative) Gene_expression (negative) of telomerase in somatic cells
20) Confidence 0.08 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.21 Pain Relevance 0

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