INT86369

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 40
Total Number 40
Disease Relevance 26.66
Pain Relevance 3.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PCNA) nucleoplasm (PCNA) nucleolus (PCNA)
nucleus (PCNA) DNA binding (PCNA) transcription factor binding (PCNA)
Anatomy Link Frequency
HGF 8
liver 4
tendon 4
esophagus 4
hepatocytes 2
PCNA (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 13 99.40 Very High Very High Very High
Pain 7 91.72 High High
Inflammation 68 88.20 High High
imagery 4 87.28 High High
Tendonitis 6 86.12 High High
COX-2 inhibitor 36 81.68 Quite High
aspirin 38 81.36 Quite High
palliative 6 79.68 Quite High
anesthesia 30 78.96 Quite High
cINOD 25 78.80 Quite High
Disease Link Frequency Relevance Heat
Ulcers 13 99.98 Very High Very High Very High
Cataract 130 99.90 Very High Very High Very High
Cleidocranial Dysplasia 30 99.84 Very High Very High Very High
Metastasis 133 99.82 Very High Very High Very High
Shock 25 99.74 Very High Very High Very High
Osteosclerosis 12 99.54 Very High Very High Very High
Cancer 962 99.38 Very High Very High Very High
Breast Cancer 493 99.34 Very High Very High Very High
Hyperplasia 32 99.20 Very High Very High Very High
Carcinoma 155 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the serum from the HCAO patient significantly stimulated the MTT intensity, the level of proliferating cell nuclear antigen expression, a proliferation marker, and ALP activity in MC3T3-E1 cells, compared with that from the control subject.
Positive_regulation (stimulated) of Gene_expression (expression) of proliferating cell nuclear antigen in MC3T3-E1 associated with osteosclerosis
1) Confidence 0.67 Published 2006 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 17177144 Disease Relevance 1.51 Pain Relevance 0.08
Proliferating cell nuclear antigen expression was enhanced, and interleukin-6 expression was reduced in the mice that received hrVEGF (p < 0.05) compared with the APAP/vehicle mice.
Positive_regulation (enhanced) of Gene_expression (expression) of Proliferating cell nuclear antigen associated with paracetamol
2) Confidence 0.67 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20363854 Disease Relevance 0.68 Pain Relevance 1.01
Significantly improved Child-Pugh scores were seen at 4 and 24 weeks (p < .05). alpha-Fetoprotein and proliferating cell nuclear antigen (PCNA) expression in liver biopsy tissue was significantly elevated after ABMI therapy (p < .05).
Positive_regulation (elevated) of Gene_expression (expression) of proliferating cell nuclear antigen in liver
3) Confidence 0.67 Published 2006 Journal Stem Cells Section Abstract Doc Link 16778155 Disease Relevance 0.42 Pain Relevance 0.11
Lansoprazole favors mucosal cell renewal simultaneously by stimulating gene expression of prosurvival proliferating cell nuclear antigen, survivin, epidermal growth factor, and basic fibroblast growth factor.
Positive_regulation (stimulating) of Gene_expression (expression) of proliferating cell nuclear antigen in fibroblast
4) Confidence 0.67 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18375387 Disease Relevance 0.69 Pain Relevance 0.22
Based on the results of animal studies in our laboratory, it appears that the mechanism of shock waves first stimulates the early expression of angiogenesis-related growth factors including eNOS (endothelial nitric oxide synthase), VEGF (vessel endothelial growth factor) and PCNA (proliferating cell nuclear antigen), then induces the ingrowth of neovascularization that improves blood supply and increases cell proliferation and eventual tissue regeneration to repair tendon or bone tissues.
Positive_regulation (stimulates) of Gene_expression (expression) of proliferating cell nuclear antigen in tendon associated with shock
5) Confidence 0.49 Published 2003 Journal Chang Gung Med J Section Abstract Doc Link 12846521 Disease Relevance 1.38 Pain Relevance 0.33
AEC2 from hyperoxic pups also expressed increased levels of proliferating cell nuclear antigen early in life compared with control neonatal AEC2, suggesting that oxygen-induced proliferation and/or repair were occurring.
Positive_regulation (increased) of Gene_expression (expressed) of proliferating cell nuclear antigen in AEC2
6) Confidence 0.45 Published 2002 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12225951 Disease Relevance 0.09 Pain Relevance 0.12
Characterization of these cells using confocal microscopy, FACs analysis and western blotting showed that they expressed melanoma-associated antigens; Melan-A, MAGE-1, and MAGE-3, and PCNA expression was higher in fast-proliferating isolates.
Positive_regulation (higher) of Gene_expression (expression) of PCNA associated with melanoma
7) Confidence 0.45 Published 2009 Journal In Vitro Cell. Dev. Biol. Anim. Section Abstract Doc Link 19057970 Disease Relevance 1.01 Pain Relevance 0.08
Increments of ulcer PCNA expression (+2.5 folds vs normal) were enhanced further by pantoprazole or famotidine, alone or in combination with indomethacin (+8.6 and +10.3 folds vs normal, respectively).
Positive_regulation (enhanced) of Gene_expression (expression) of PCNA associated with ulcers
8) Confidence 0.20 Published 2009 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 18853145 Disease Relevance 0.78 Pain Relevance 0.07
To compare the localization of EGFP-hOGG1, EGFP-hOGG1-Cys326 and EGFP-hOGG1-Glu326 in living cells during S-phase, stable cell lines were transiently transfected with HcRed-PCNA.
Positive_regulation (transfected) of Gene_expression (transfected) of HcRed-PCNA
9) Confidence 0.18 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0.04
Based on the results of animal studies in our laboratory, it appears that the mechanism of shock waves first stimulates the early expression of angiogenesis-related growth factors including eNOS (endothelial nitric oxide synthase), VEGF (vessel endothelial growth factor) and PCNA (proliferating cell nuclear antigen), then induces the ingrowth of neovascularization that improves blood supply and increases cell proliferation and eventual tissue regeneration to repair tendon or bone tissues.
Positive_regulation (stimulates) of Gene_expression (expression) of PCNA in tendon associated with shock
10) Confidence 0.16 Published 2003 Journal Chang Gung Med J Section Abstract Doc Link 12846521 Disease Relevance 1.37 Pain Relevance 0.33
-null mice, although PCNA protein expression increased with exposure in three groups.
Positive_regulation (increased) of Gene_expression (expression) of PCNA protein
11) Confidence 0.15 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974693 Disease Relevance 0.54 Pain Relevance 0
These data suggest that the residual tumor cells facilitate tumor growth and metastasis through induction of overexpression of PCNA, MMP-9, VEGF, HGF and IL-6.
Positive_regulation (induction) of Gene_expression (overexpression) of PCNA in HGF associated with residual neoplasm, cancer and metastasis
12) Confidence 0.14 Published 2010 Journal J Transl Med Section Body Doc Link PMC2917410 Disease Relevance 1.26 Pain Relevance 0
These data suggest that the residual tumor cells facilitate tumor growth and metastasis through induction of overexpression of PCNA, MMP-9, VEGF, HGF and IL-6.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PCNA in HGF associated with residual neoplasm, cancer and metastasis
13) Confidence 0.14 Published 2010 Journal J Transl Med Section Body Doc Link PMC2917410 Disease Relevance 1.25 Pain Relevance 0
We transiently co-transfected HeLa S3 cells with EYFP-hOGG1 and ECFP-PCNA and followed the cells for 20 h.
Positive_regulation (transfected) of Gene_expression (transfected) of ECFP-PCNA in HeLa S3
14) Confidence 0.13 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0 Pain Relevance 0.04
COX-2 expression increased similarly in alveolar hyperplasia and alveolar atypical dysplasia, while PCNA expression increased more significantly in the latter than the former.
Positive_regulation (increased) of Gene_expression (expression) of PCNA associated with cleidocranial dysplasia and hyperplasia
15) Confidence 0.12 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC1899177 Disease Relevance 0.80 Pain Relevance 0.29
These LEC were immunopositive for COX-2, PCNA, and ?
Positive_regulation (for) of Gene_expression (immunopositive) of PCNA
16) Confidence 0.12 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.64 Pain Relevance 0
Similarly, incomplete RFA significantly elevated protein expression of VEGF and PCNA in groups I, II and III.
Positive_regulation (elevated) of Gene_expression (expression) of PCNA
17) Confidence 0.12 Published 2010 Journal J Transl Med Section Body Doc Link PMC2917410 Disease Relevance 0.69 Pain Relevance 0.03
Significantly improved Child-Pugh scores were seen at 4 and 24 weeks (p < .05). alpha-Fetoprotein and proliferating cell nuclear antigen (PCNA) expression in liver biopsy tissue was significantly elevated after ABMI therapy (p < .05).
Positive_regulation (elevated) of Gene_expression (expression) of PCNA in liver
18) Confidence 0.11 Published 2006 Journal Stem Cells Section Abstract Doc Link 16778155 Disease Relevance 0.41 Pain Relevance 0.11
Immunohistochemical staining revealed that the remaining LEC (1) expressed a moderate amount of COX-2, (2) were strongly immunoreactive for cleaved caspase-3, (3) did not express PCNA, and (4) showed decreased ?
Positive_regulation (immunoreactive) of Neg (not) Gene_expression (express) of PCNA
19) Confidence 0.10 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765474 Disease Relevance 0.15 Pain Relevance 0
Residual hepatic VX2 carcinoma could facilitate its rapid progression through inducing overexpression of several molecular factors, such as PCNA, MMP-9, VEGF, HGF and IL-6.



Positive_regulation (overexpression) of Gene_expression (overexpression) of PCNA in HGF associated with carcinoma
20) Confidence 0.09 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2917410 Disease Relevance 0.63 Pain Relevance 0.03

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