INT8637

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 112
Total Number 114
Disease Relevance 33.28
Pain Relevance 8.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Dbp)
Anatomy Link Frequency
blood 19
heart 5
inferior 2
GPI 1
caudate-putamen 1
Dbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 272 100.00 Very High Very High Very High
Opioid 8 100.00 Very High Very High Very High
fibrosis 82 99.80 Very High Very High Very High
nMDA receptor 1 99.68 Very High Very High Very High
Clonidine 30 99.54 Very High Very High Very High
Onset of action 24 99.10 Very High Very High Very High
depression 11 98.84 Very High Very High Very High
cva 47 98.68 Very High Very High Very High
lidocaine 6 97.82 Very High Very High Very High
Dopamine 6 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 75 99.84 Very High Very High Very High
Cystic Fibrosis 73 99.80 Very High Very High Very High
Bradycardia 19 99.80 Very High Very High Very High
Obesity 107 99.68 Very High Very High Very High
Diabetes Mellitus 574 99.56 Very High Very High Very High
Respiratory Failure 2 99.32 Very High Very High Very High
Heart Failure 3 99.04 Very High Very High Very High
Heart Rate Under Development 149 98.96 Very High Very High Very High
Hypertension 1913 98.68 Very High Very High Very High
Cv General 3 Under Development 61 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patients with moderate hypertension (DBP less than 120 mmHg), the three dosage levels resulted in normalization of DBP (less than 95 mmHg) in 80 to 85 p. 100 of the cases, but in those with severe hypertension only doses of 150 and 200 mg/day were effective in significantly reducing DBP in 50 to 65 p. 100 of the cases.
Negative_regulation (reducing) of DBP associated with hypertension
1) Confidence 0.50 Published 1989 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 2514676 Disease Relevance 0.80 Pain Relevance 0.09
Over the trial period of 8 weeks, felodipine reduced dBP from 102 to 85 mmHg and hydrochlorothiazide from 101 to 91 mmHg; the dBP reduction in the felodipine group was greater than that in the hydrochlorothiazide group (17 vs 9 mmHg) and the attained dBP lower in the felodipine group.
Negative_regulation (reduced) of dBP
2) Confidence 0.49 Published 1988 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 3282893 Disease Relevance 0.15 Pain Relevance 0.04
Mean decreases of systolic blood pressure (SBP) and diastolic blood pressure (DBP) were ?
Negative_regulation (decreases) of DBP in blood
3) Confidence 0.48 Published 2006 Journal International Journal of Clinical Practice Section Abstract Doc Link PMC1636683 Disease Relevance 0.31 Pain Relevance 0.08
Mean decreases in SBP and DBP were 18.5 ± 3.3 and 13.8 ± 2.3 mmHg in the low risk group, 23 ± 3.9 and 15.2 ± 2.7 mmHg in the medium risk group, 24.4 ± 4.0 and 16.1 ± 3.1 mmHg in the high risk group, and 27.4 ± 4.2 and 17.4 ± 3.2 mmHg in the very high risk group.
Negative_regulation (decreases) of DBP
4) Confidence 0.48 Published 2006 Journal International Journal of Clinical Practice Section Body Doc Link PMC1636683 Disease Relevance 0.12 Pain Relevance 0
At the end of treatment (week 6), there were statistically significant decreases (p less than 0.01) in supine SBP and DBP in both groups compared with baseline values: the mean SBP in groups A and B decreased from 160.0 +/- 14.7 to 133.6 +/- 10.0 mm Hg and from 161.6 +/- 17.8 to 134.8 +/- 10.9 mm Hg, respectively; the mean DBP in groups A and B decreased from 101.3 +/- 3.0 to 83.6 +/- 5.5 mm Hg and from 101.3 +/- 8.4 to 84.2 +/- 3.6 mm Hg, respectively.
Negative_regulation (decreases) of DBP
5) Confidence 0.43 Published 1992 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1376836 Disease Relevance 0.41 Pain Relevance 0.07
PROP was associated with the most decrease in SBP and DBP and in addition respiratory depression (p less than 0.05).
Negative_regulation (decrease) of DBP in respiratory associated with depression and respiratory failure
6) Confidence 0.43 Published 1987 Journal Can J Anaesth Section Abstract Doc Link 3499244 Disease Relevance 0.36 Pain Relevance 0.14
Mean DBP and SBP reductions were apparent from week 4 and maintained throughout the treatment period.
Negative_regulation (reductions) of DBP
7) Confidence 0.42 Published 2003 Journal J. Int. Med. Res. Section Abstract Doc Link 14708422 Disease Relevance 0.33 Pain Relevance 0.09
In adults, MeHg has been associated with decreasing DBP and increasing PP in Greenlanders [9] and increased risk of hypertension in inhabitants of the Brazilian Amazon [20].
Negative_regulation (decreasing) of DBP associated with hypertension
8) Confidence 0.41 Published 2008 Journal Environ Health Section Body Doc Link PMC2443124 Disease Relevance 0.41 Pain Relevance 0
N, C, and G3 significantly reduced SBP, DBP, and MAP (P less than .01).
Negative_regulation (reduced) of DBP
9) Confidence 0.40 Published 1991 Journal Am J Emerg Med Section Abstract Doc Link 1994934 Disease Relevance 0.34 Pain Relevance 0.06
The decrease in SBP and DBP at each follow-up visit compared with baseline was statistically significant both in the intergroup and intragroup comparisons (p < 0.001, one-way ANOVA).
Negative_regulation (decrease) of DBP
10) Confidence 0.40 Published 2006 Journal International Journal of Clinical Practice Section Body Doc Link PMC1636683 Disease Relevance 0.30 Pain Relevance 0
In our study, we have observed that 25 mg of (S)-atenolol alone could reduce SBP, DBP, and HR significantly (P < 0·0001) at the end of 1 month of treatment and it was maintained throughout our study.
Negative_regulation (reduce) of DBP
11) Confidence 0.40 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991702 Disease Relevance 0.12 Pain Relevance 0
Although there was no difference between the groups with respect to reduction of SBP and DBP, decrease in HR was significantly greater in patients receiving (S)-atenolol.
Negative_regulation (reduction) of DBP
12) Confidence 0.40 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991702 Disease Relevance 0.16 Pain Relevance 0
KEY RESULTS: In anaesthetized rats, anandamide (1.5-3 micromol.kg(-1)) and its stable analogue methanandamide (0.5 micromol.kg(-1)) caused a delayed and prolonged decrease in MBP, SBP, DBP, MBF and RBF by about 10-30% of the respective basal values without changing HR.
Negative_regulation (decrease) of DBP
13) Confidence 0.39 Published 2010 Journal Br. J. Pharmacol. Section Body Doc Link 20105178 Disease Relevance 0.08 Pain Relevance 0
Isoproterenol at doses of 0.01-1 microgram/kg (i.v.) dose-dependently increased HR and BAT blood flow and decreased DBP.
Negative_regulation (decreased) of DBP in BAT associated with obesity
14) Confidence 0.38 Published 1994 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 7982286 Disease Relevance 0.78 Pain Relevance 0.11
Secondary efficacy variables included mean changes in DBP, systolic blood pressure (SBP), and response rate (defined as the proportion of patients whose DBP was <90 mm Hg or whose DBP had decreased from baseline by > or =10 mm Hg).
Negative_regulation (decreased) of DBP in blood
15) Confidence 0.37 Published 2005 Journal Clin Ther Section Body Doc Link 16117979 Disease Relevance 0 Pain Relevance 0
Intravenous injection of verapamil (0.3 mg/kg) considerably lowered DBP.
Negative_regulation (lowered) of DBP
16) Confidence 0.37 Published 1985 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 4029805 Disease Relevance 0.27 Pain Relevance 0.07
After 14 weeks of treatment with doxazosin, a significant (p less than 0.05) reduction in systolic blood pressure and DBP was observed.
Negative_regulation (reduction) of DBP in blood
17) Confidence 0.37 Published 1991 Journal Am. Heart J. Section Abstract Doc Link 1824663 Disease Relevance 0.39 Pain Relevance 0.22
Over the trial period of 8 weeks, felodipine reduced dBP from 102 to 85 mmHg and hydrochlorothiazide from 101 to 91 mmHg; the dBP reduction in the felodipine group was greater than that in the hydrochlorothiazide group (17 vs 9 mmHg) and the attained dBP lower in the felodipine group.
Negative_regulation (reduction) of dBP
18) Confidence 0.36 Published 1988 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 3282893 Disease Relevance 0.15 Pain Relevance 0.04
Decreases in SBP and DBP in each cardiovascular risk group at the follow-up compared with baseline are shown in Figures 1 and 2.
Negative_regulation (Decreases) of DBP
19) Confidence 0.35 Published 2006 Journal International Journal of Clinical Practice Section Body Doc Link PMC1636683 Disease Relevance 0.05 Pain Relevance 0
In this study both the drugs nebivolol and (S)-atenolol reduced SBP, DBP, and HR, but the reduction of SBP and DBP when compared between the groups at the end of 3 months was not statistically significant.
Negative_regulation (reduction) of DBP
20) Confidence 0.35 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991702 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox