INT8638

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Context Info
Confidence 0.44
First Reported 1992
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.57
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Vldlr) extracellular space (Vldlr) nucleus (Vldlr)
Anatomy Link Frequency
fat 1
cortex 1
Vldlr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 1 97.64 Very High Very High Very High
fluoxetine 1 93.56 High High
headache 1 88.88 High High
beta blocker 2 82.08 Quite High
depression 1 78.48 Quite High
GABAergic 3 73.12 Quite High
Angina 1 68.52 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 4 99.20 Very High Very High Very High
Headache 1 88.88 High High
Increased Venous Pressure Under Development 1 87.44 High High
Heart Rate Under Development 1 86.00 High High
Cv Unclassified Under Development 1 85.20 High High
Pressure And Volume Under Development 1 83.12 Quite High
Depression 1 78.48 Quite High
Manic Depressive Disorder 1 77.60 Quite High
Schizophrenia 1 76.88 Quite High
Autism 1 76.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The current study investigated whether chronic administration of psychotropic medications (clozapine, fluoxetine, haloperidol, lithium, olanzapine, and valproic acid) used in the treatment of psychiatric disorders alters levels of Reelin, its receptor Vldlr, downstream molecules Gsk3 beta, Dab-1, and Gad65/67 in rat prefrontal cortex as measured by qRT-PCR and SDS-PAGE and western blotting. qRT-PCR revealed that mRNAs for Reelin, Vldlr, Dab-1, Gsk3 beta, and Gad65 were each significantly altered by at least one of the drugs tested, and in the case of Reelin, Dab-1, and Gsk3 beta, by multiple drugs.
Regulation (altered) of Vldlr in cortex associated with fluoxetine
1) Confidence 0.44 Published 2009 Journal Schizophr. Res. Section Abstract Doc Link 19359144 Disease Relevance 0.38 Pain Relevance 0.23
Very-low-density lipoprotein (VLDL) cholesterol did not change, nor did other biochemical laboratory tests, or electrocardiographic and echocardiographic parameters.
Neg (not) Regulation (change) of Very-low-density lipoprotein
2) Confidence 0.20 Published 1992 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1376837 Disease Relevance 0.77 Pain Relevance 0.09
Metoprolol treatment significantly increased the postprandial responses of very low density lipoprotein (VLDL) and VLDL remnants to a mixed meal-type of oral fat tolerance test.
Regulation (responses) of very low density lipoprotein in fat associated with tolerance
3) Confidence 0.10 Published 1998 Journal Atherosclerosis Section Abstract Doc Link 9622282 Disease Relevance 0.42 Pain Relevance 0.20

General Comments

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