INT86382

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 1.75
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EGF) extracellular space (EGF) extracellular region (EGF)
plasma membrane (EGF)
EGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 20 99.76 Very High Very High Very High
cINOD 7 99.22 Very High Very High Very High
antagonist 4 93.60 High High
qutenza 4 91.16 High High
agonist 4 89.60 High High
aspirin 1 71.88 Quite High
palliative 2 39.52 Quite Low
bDMF 36 5.00 Very Low Very Low Very Low
Nerve growth factor 18 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 33 99.86 Very High Very High Very High
Toxicity 10 95.16 Very High Very High Very High
Apoptosis 6 89.08 High High
Wound Healing 2 86.24 High High
Colon Cancer 4 76.64 Quite High
Injury 5 75.76 Quite High
Carcinoma 2 75.00 Quite High
INFLAMMATION 2 75.00 Quite High
Disease 16 72.88 Quite High
Head & Neck Cancer 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data support our premise that one mechanism whereby NSAIDs may attenuate colonic neoplasia is by blocking EGF-induced Ca++ mobilization.
Negative_regulation (blocking) of Localization (mobilization) of EGF-induced associated with cancer and cinod
1) Confidence 0.43 Published 2000 Journal J. Gastrointest. Surg. Section Abstract Doc Link 10675238 Disease Relevance 0.25 Pain Relevance 0.21
Finally, cetuximab may block the nuclear import of EGF-R, preventing activation of the DNA repair mechanism that protects cells from radiation- or chemotherapy-induced DNA damage [7-9].
Spec (may) Negative_regulation (block) of Localization (import) of EGF-R
2) Confidence 0.30 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2868849 Disease Relevance 0.61 Pain Relevance 0
Finally, cetuximab may block the nuclear import of EGF-R, preventing activation of the DNA repair mechanism that protects cells from radiation- or chemotherapy-induced DNA damage [7-9].
Negative_regulation (preventing) of Localization (import) of EGF-R
3) Confidence 0.30 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2868849 Disease Relevance 0.56 Pain Relevance 0
Furthermore, EGFR transactivation was abolished by inhibitors of proteolytic release of heparin bound EGF (HB-EGF).
Negative_regulation (inhibitors) of Localization (release) of EGF
4) Confidence 0.24 Published 2010 Journal Exp. Eye Res. Section Abstract Doc Link 20619260 Disease Relevance 0.16 Pain Relevance 0.62
Furthermore, EGFR transactivation was abolished by inhibitors of proteolytic release of heparin bound EGF (HB-EGF).
Negative_regulation (inhibitors) of Localization (release) of EGF
5) Confidence 0.24 Published 2010 Journal Exp. Eye Res. Section Abstract Doc Link 20619260 Disease Relevance 0.16 Pain Relevance 0.61
A list of all these promoters is provided in Table 6 and comprises several neurotrophins and growth factors, such as FGF, EGF, Pleiotrophin, or PEDF, morphogens from the TGF?
Negative_regulation (as) of Localization (morphogens) of EGF
6) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0
A list of all these promoters is provided in Table 6 and comprises several neurotrophins and growth factors, such as FGF, EGF, Pleiotrophin, or PEDF, morphogens from the TGF?
Negative_regulation (comprises) of Localization (morphogens) of EGF
7) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0
A list of all these promoters is provided in Table 6 and comprises several neurotrophins and growth factors, such as FGF, EGF, Pleiotrophin, or PEDF, morphogens from the TGF?
Negative_regulation (comprises) of Localization (several) of EGF
8) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004953 Disease Relevance 0 Pain Relevance 0

General Comments

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