INT86384

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.50
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 51 99.48 Very High Very High Very High
cINOD 8 98.90 Very High Very High Very High
Inflammation 5 87.68 High High
imagery 7 50.00 Quite Low
aspirin 1 48.28 Quite Low
fibrosis 27 38.32 Quite Low
Antihistamine 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 2 99.80 Very High Very High Very High
INFLAMMATION 7 98.78 Very High Very High Very High
Mixed Connective Tissue Disorder 1 90.64 High High
Hyperplasia 1 90.20 High High
Cancer 42 90.08 High High
Apoptosis 3 89.24 High High
Nephrotoxicity 5 88.84 High High
Necrosis 1 86.60 High High
Disease 15 86.56 High High
Increased Venous Pressure Under Development 4 84.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in the presence of cetuximab, EGFR nuclear import and subsequent activation of DNA repair mechanisms after radiation exposure were inhibited, and radiosensitivity was enhanced (Dittmann et al 2005).
Negative_regulation (inhibited) of Localization (import) of EGFR
1) Confidence 0.43 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721306 Disease Relevance 0.85 Pain Relevance 0
Definition of serum creatinine (SCr) (not older than 2 weeks) and calculation of eGFR for
Negative_regulation (Definition) of Localization (calculation) of eGFR
2) Confidence 0.19 Published 2007 Journal MAGMA Section Body Doc Link PMC2797854 Disease Relevance 1.16 Pain Relevance 0.10
in the presence/absence of the FP receptor antagonist (AL8810), EP2 receptor antagonist (AH6809), EP4 receptor antagonist (ONOAE2227), or chemical inhibitors of PLC (U73122), PKA (4C3MQ), PKC (GF109203x), EGFR kinase (AG1478) or ERK1/2 kinase (PD98059).
Negative_regulation (inhibitors) of Localization (kinase) of EGFR associated with antagonist
3) Confidence 0.12 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0 Pain Relevance 0.32
Nonsteroidal anti-inflammatory drugs attenuate proliferation of colonic carcinoma cells by blocking epidermal growth factor-induced Ca++ mobilization.
Negative_regulation (blocking) of Localization (mobilization) of epidermal growth factor-induced associated with inflammation, cinod and carcinoma
4) Confidence 0.07 Published 2000 Journal J. Gastrointest. Surg. Section Title Doc Link 10675238 Disease Relevance 0.48 Pain Relevance 0.55

General Comments

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